Circulation. 2006;114:1883-1891
doi: 10.1161/CIRCULATIONAHA.106.632208
doi: 10.1161/CIRCULATIONAHA.106.632208
(Circulation. 2006;114:1883-1891.)
© 2006 American Heart Association, Inc.
Special Report |
Right Ventricular Function and Failure
Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure
From the Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver (N.F.V.); Department of Nuclear Medicine and Radiology, University of Colorado Hospital, Denver (R.A.Q.); CVI Institute, Department of Cardiology, Colorado University (L.A.L.); Columbia-Presbyterian Medical Center Babies Hospital, New York, NY (R.J.B.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn (M.D.M.); Pulmonary Hypertension Association (M.D.M.); Department of Surgery, Indiana University School of Medicine (D.R.M.); Research Center, Montreal Heart Institute, Montreal, Quebec, Canada (J.D.); Department of Cardiology, University of Colorado at Denver and Health Sciences Center, Denver (C.S.L.); Pulmonary Hypertension Center, University of California at San Diego (L.J.R.); Baylor College of Medicine, St Luke’s Episcopal Hospital/Texas Heart Institute, Houston (F.W.S.); Georgetown University Medical Center, Washington, DC (Y.J.S.); and National Heart, Lung, and Blood Institute, Bethesda, Md (M.G., E.M.D., D.B.G.).
Correspondence to Norbert F. Voelkel, MD, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, 4200 E Ninth Ave, MC: C272, Denver, CO 80262. E-mail norbert.voelkel@uchsc.edu
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
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Introduction |
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Knowledge about the role of the right ventricle in health and disease historically has lagged behind that of the left ventricle. Less muscular, restricted in its role to pumping blood through a single organ, and less frequently or obviously involved than the left ventricle in diseases of epidemic proportions such as myocardial ischemia, cardiomyopathy, or valvulopathy, the right ventricle has generally been considered a mere bystander, a victim of pathological processes affecting the cardiovascular system. Consequently, comparatively little attention has been devoted to how right ventricular dysfunction may be best detected and measured, what specific molecular and cellular mechanisms contribute to maintenance or failure of normal right ventricular function, how right ventricular dysfunction evolves structurally and functionally, or what interventions might best preserve right ventricular function. Nevertheless, even the proportionately limited information related to right ventricular function, its impairment in various disease states, and its impact on the outcome of those diseases suggests that the right ventricle is an important contributor and that further understanding of these issues is of pivotal importance.
For this reason, the National Heart, Lung, and Blood Institute convened a working group charged with delineating in broad terms the current base of scientific and medical understanding about the right ventricle and identifying avenues of investigation likely to meaningfully advance knowledge in a clinically useful direction. The following summary represents the presentations and discussions of this working group.
The right ventricle is affected by and contributes to a number of disease processes, including perhaps most notably pulmonary
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