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(Circulation. 2006;113:e84.)
© 2006 American Heart Association, Inc.

Book Reviews

Angiogenesis and Direct Myocardial Revascularization

Sanjay Rajagopalan, MD

Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	Introduction

 
Roger J. Laham, MD, Donald S. Baim, MD, eds
357 pages. Hoboken, NJ: Humana Press; 2005. $145.00. ISBN 1–58829–153–7

"The ability to perceive or think differently is more important than the knowledge gained"

— David Bohm

The concept of creating networks of blood vessels through the simple infusion of growth factors has caught the imagination of physicians and lay public alike since its first description. Although the heady days of unbridled enthusiasm have now been replaced with the grim reality of the challenges, this notion nonetheless was critical in spearheading new concepts and approaches to entice the body to create blood vessel networks with the ultimate goal of improving form and function. A variety of strategies ranging from the simple direct infusion of growth factors to the expression of genes delivered via plasmids and adenoviral approaches has been tried for the treatment of myocardial and peripheral disorders with limited success. Despite these initial failures, what is remarkable about this field is the rapidity with which approaches and paradigms have changed as knowledge has been assimilated, and the rapid evolution of bench to the bedside approaches. Thus, although the focus of the past decade has been more about how things in the world of angiogenesis do not quite work the way we think they do, the true contribution of this field is that no concept is too radical to consider and test. The areas of angiogenesis and antiangiogenesis have in some ways been harbingers to the era of cell therapy and . . . [Full Text of this Article]