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(Circulation. 2005;112:I-332 – I-337.)
© 2005 American Heart Association, Inc.

Surgery for Coronary Artery Disease

Aborted Off-Pump Coronary Artery Bypass Patients Have Much Worse Outcomes Than On-Pump or Successful Off-Pump Patients

Ruyun Jin, MD; Loren F. Hiratzka, MD; Gary L. Grunkemeier, PhD; Albert Krause, MD; U. Scott Page, III, MD

From Health Data Research, Inc (L.F.H., A.K., U.S.P.) and Providence Health System (R.J., G.L.G.), Portland, Ore.

Correspondence to U. Scott Page, III, Health Data Research, Inc, 5201 SW Westgate Dr, Suite 213, Portland, OR 97221. E-mail usp.hdr{at}comcast.net

Background— Off-pump coronary artery bypass graft (CABG) surgery is purported to reduce perioperative mortality and morbidity compared with on-pump coronary bypass graft surgery. However, the outcomes of patients for whom an off-pump strategy must be changed to an on-pump procedure during surgery have not been extensively studied.

Methods and Results— The Merged Cardiac Registry (Health Data Research, Inc) contains 70 514 isolated CABG performed from January 1998 to March 2004 in 40 facilities. Among them, 62 634 patients begun and completed on-pump bypass (CPB); 7880 patients begun off-pump, of which 7424 (94.2%) completed off-pump coronary artery bypass (OPCAB), whereas 456 (5.8%) were converted to on-pump (CONVERT). CONVERT patients were more severely ill. The observed mortality of CONVERT, CPB, and OPCAB was 9.9%, 3.0%, and 1.6%, respectively, and the observed-to-predicted ratio was 2.77, 1.20, and 0.74, respectively. CONVERT also had more morbidity than either OPCAB or CPB. Finally, a risk model was created to identify patients who might be at risk for conversion from off-pump to on-pump CABG.

Conclusions— Patients who are intended for an off-pump strategy and then require conversion to on-pump have significantly higher operative mortality and morbidity than either completed OPCAB or CPB patients. In addition, the operative mortality and morbidity are far in excess of that predicted preoperatively. Based on these results, strong consideration should be given for a planned strategy of CPB for those patients with preoperative hemodynamic instability requiring a salvage CABG operation, left ventricular hypertrophy, or previous CABG.

Key Words: coronary disease • mortality • off-pump • on-pump • surgery

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