Published online before print July 25, 2005, doi: 10.1161/CIRCULATIONAHA.104.529297
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(Circulation. 2005;112:651-657.)
© 2005 American Heart Association, Inc.
Epidemiology |
Plasma Oxidized Low-Density Lipoprotein, a Strong Predictor for Acute Coronary Heart Disease Events in Apparently Healthy, Middle-Aged Men From the General Population
From GSF the National Research Center for Environment and Health (C.M., J.B., H.L.), Institute of Epidemiology, Neuherberg; the Central Hospital of Augsburg (C.M., H.L.), MONICA/KORA Myocardial Infarction Registry, Augsburg; and the Department of Internal Medicine II–Cardiology (N.K., W.K), University of Ulm Medical Center, Ulm, Germany.
Correspondence to Prof Wolfgang Koenig, MD, FESC, FACC, Department of Internal Medicine II–Cardiology, University of Ulm Medical Center, Robert-Koch Strasse 8, D-89081 Ulm, Germany. E-mail wolfgang.koenig{at}medizin.uni-ulm.de
Received October 12, 2004; de novo received December 14, 2004; revision received April 6, 2005; accepted April 12, 2005.
Background— Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall.
Methods and Results— In a prospective, nested, case-control study, the association between plasma oxLDL and risk of an acute coronary heart disease (CHD) event was investigated in men without prevalent CHD or diabetes mellitus at baseline. Subjects came from 2 population-based MONICA/KORA Augsburg surveys conducted in the years 1989–1990 and 1994–1995 with follow-up in 1998 (mean±SD follow-up time, 5.6±2.6 years). OxLDL was determined by ELISA in 88 men with incident CHD and in 258 age- and survey-matched controls. Hazard ratios (HRs) were estimated from conditional logistic-regression models with matching for age and survey. Baseline mean plasma oxLDL concentrations were significantly higher in subjects who subsequently experienced an event compared with controls (mean±SD, 110±32 versus 93±28 U/L; P
0.001). After adjustment for smoking, hypertension, obesity, physical activity, education, and alcohol consumption, the HR for a future CHD event in a comparison of the upper tertile of the oxLDL distribution with the lower tertile was 4.25 (95% confidence interval, 2.09 to 8.63; P<0.001). Plasma oxLDL was the strongest predictor of CHD events compared with a conventional lipoprotein profile and other traditional risk factors for CHD. When both oxLDL and C-reactive protein were simultaneously assessed in the same model, they still predicted future CHD events even after multivariable adjustment.
Conclusions— Elevated concentrations of oxLDL are predictive of future CHD events in apparently healthy men. Thus, oxLDL may represent a promising risk marker for clinical CHD complications and should be evaluated in further studies.
Key Words: lipoproteins • inflammation • coronary disease • metabolism • risk factors
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