Circulation. 2005;112:1580-1586
Published online before print September 6, 2005, doi: 10.1161/CIRCULATIONAHA.105.538272
Published online before print September 6, 2005, doi: 10.1161/CIRCULATIONAHA.105.538272
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(Circulation. 2005;112:1580-1586.)
© 2005 American Heart Association, Inc.
Heart Failure |
Left Ventricular Reverse Remodeling but Not Clinical Improvement Predicts Long-Term Survival After Cardiac Resynchronization Therapy
From the Division of Cardiology (C.-M.Y., J.W.-H.F., Q.Z., Y.-S.C., S.-L.K.), Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, and the Department of Cardiology (G.B.B., M.J.S., E.E.v.d.W., J.J.B.), Leiden University Medical Center, Leiden, the Netherlands.
Reprint requests to Prof Cheuk-Man Yu, Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong. E-mail cmyu{at}cuhk.edu.hk
Received January 24, 2005; revision received June 16, 2005; accepted June 20, 2005.
Background— In patients with severe heart failure and dilated cardiomyopathy, cardiac resynchronization therapy (CRT) improves left ventricular (LV) systolic function associated with LV reverse remodeling and favorable 1-year survival. However, it is unknown whether LV reverse remodeling translates into a better long-term prognosis and what extent of reverse remodeling is clinically relevant, which were investigated in this study.
Methods and Results— Patients (n=141) with advanced heart failure (mean±SD age, 64±11 years; 73% men) who received CRT were followed up for a mean (±SD) of 695±491 days. The extent of reduction in LV end-systolic volume (LVESV) at 3 to 6 months relative to baseline was examined for its predictive value on long-term clinical outcome. The cutoff value for LV reverse remodeling in predicting mortality was derived from the receiver operating characteristic curve. Then the relation between potential predictors of mortality and heart failure hospitalizations were compared by Kaplan-Meier survival analysis, followed by Cox regression analysis. There were 22 (15.6%) deaths, mostly due to heart failure or sudden cardiac death. The receiver operating characteristic curve found that a reduction in LVESV of 
9.5% had a sensitivity of 70% and specificity of 70% in predicting all-cause mortality and of 87% and 69%, respectively, for cardiovascular mortality. With this cutoff value, there were 87 (61.7%) responders to reverse remodeling. In Kaplan-Meier survival analysis, responders had significantly lower all-cause morality (6.9% versus 30.6%, log-rank 
2=13.26, P=0.0003), cardiovascular mortality (2.3% versus 24.1%, log-rank 2=17.1, P<0.0001), and heart failure events (11.5% versus 33.3%, log-rank 2=8.71, P=0.0032) than nonresponders. In the Cox regression analysis model, the change in LVESV was the single most important predictor of all-cause (ß=1.048, 95% confidence interval=1.019 to 1.078, P=0.001) and cardiovascular (ß=1.072, 95% confidence interval=1.033 to 1.112, P<0.001) mortality. Clinical parameters were unable to predict any outcome event.
Conclusions— A reduction in LVESV of 10% signifies clinically relevant reverse remodeling, which is a strong predictor of lower long-term mortality and heart failure events. This study suggests that assessing volumetric changes after an intervention in patients with heart failure provides information predictive of natural history outcomes.
Key Words: pacing • prognosis • heart failure • echocardiography • mortality
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C.-M. Yu, F. Fang, Q. Zhang, G. W.K. Yip, C. M. Li, J. Y.-S. Chan, L. Wu, and J. W.-H. Fung Improvement of Atrial Function and Atrial Reverse Remodeling After Cardiac Resynchronization Therapy for Heart Failure J. Am. Coll. Cardiol., August 21, 2007; 50(8): 778 - 785. [Abstract] [Full Text] [PDF]
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R. N. Doughty, K. Poppe, and J. Stewart Predicting outcome in severe heart failure. Who will benefit from device therapy (CRT)? Eur. Heart J., August 1, 2007; 28(15): 1790 - 1792. [Full Text] [PDF]
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J. N. Kirkpatrick, M. A. Vannan, J. Narula, and R. M. Lang Echocardiography in Heart Failure: Applications, Utility, and New Horizons J. Am. Coll. Cardiol., July 31, 2007; 50(5): 381 - 396. [Abstract] [Full Text] [PDF]
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S. Chalil, B. Stegemann, S. Muhyaldeen, K. Khadjooi, R. E.A. Smith, P. J. Jordan, and F. Leyva Intraventricular Dyssynchrony Predicts Mortality and Morbidity After Cardiac Resynchronization Therapy: A Study Using Cardiovascular Magnetic Resonance Tissue Synchronization Imaging J. Am. Coll. Cardiol., July 17, 2007; 50(3): 243 - 252. [Abstract] [Full Text] [PDF]
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C.-M. Yu, J. E. Sanderson, T. H. Marwick, and J. K. Oh Tissue Doppler Imaging: A New Prognosticator for Cardiovascular Diseases J. Am. Coll. Cardiol., May 15, 2007; 49(19): 1903 - 1914. [Abstract] [Full Text] [PDF]
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F. B. Tournoux, C. Alabiad, D. Fan, A. A. Chen, M. Chaput, E. K. Heist, T. Mela, M. Mansour, V. Reddy, J. N. Ruskin, et al. Echocardiographic measures of acute haemodynamic response after cardiac resynchronization therapy predict long-term clinical outcome Eur. Heart J., May 1, 2007; 28(9): 1143 - 1148. [Abstract] [Full Text] [PDF]
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J. W H Fung, J. Y S Chan, G. W K Yip, H. C K Chan, W. W L Chan, Q. Zhang, and C.-M. Yu Effect of left ventricular endocardial activation pattern on echocardiographic and clinical response to cardiac resynchronization therapy Heart, April 1, 2007; 93(4): 432 - 437. [Abstract] [Full Text] [PDF]
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C-M Yu, Q Zhang, Y-S Chan, C-K Chan, G W K Yip, L C C Kum, E B Wu, P-W Lee, Y-Y Lam, S Chan, et al. Tissue Doppler velocity is superior to displacement and strain mapping in predicting left ventricular reverse remodelling response after cardiac resynchronisation therapy Heart, October 1, 2006; 92(10): 1452 - 1456. [Abstract] [Full Text] [PDF]
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M. Gasparini, A. Auricchio, F. Regoli, C. Fantoni, M. Kawabata, P. Galimberti, D. Pini, C. Ceriotti, E. Gronda, C. Klersy, et al. Four-Year Efficacy of Cardiac Resynchronization Therapy on Exercise Tolerance and Disease Progression: The Importance of Performing Atrioventricular Junction Ablation in Patients With Atrial Fibrillation J. Am. Coll. Cardiol., August 15, 2006; 48(4): 734 - 743. [Abstract] [Full Text] [PDF]
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