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(Circulation. 2005;111:3453-3456.)
© 2005 American Heart Association, Inc.

Pediatric Cardiology

Long-Term, Randomized Comparison of Balloon Angioplasty and Surgery for Native Coarctation of the Aorta in Childhood

Collin G. Cowley, MD; Garth S. Orsmond, MD; Peter Feola, MD; Lon McQuillan, MD; Robert E. Shaddy, MD

From the Department of Pediatrics (C.G.C., G.S.O., L.M., R.E.S.), University of Utah and Primary Children’s Medical Center, and Department of Pediatric Radiology (P.F.), Primary Children’s Medical Center, Salt Lake City, Utah.

Correspondence to Collin G. Cowley, MD, Division of Pediatric Cardiology, 100 N Medical Dr, Salt Lake City, UT 84113. E-mail collin.cowley{at}hsc.utah.edu

Received September 29, 2004; revision received February 9, 2005; accepted March 2, 2005.

Background— The purpose of this study was to compare the long-term outcomes of children randomized to surgery or balloon angioplasty (BA) for native coarctation (CoA). A prior randomized, short-term comparison of BA and surgery for native CoA in 36 children demonstrated equivalent relief of obstruction. The risk of aneurysm formation and possibly restenosis was higher among patients treated with BA.

Methods and Results— Blood pressure, residual aortic obstruction, and exercise performance were evaluated. Need for repeat intervention was reviewed. Aortic arch anatomy was assessed with magnetic resonance angiography. For subjects who were not available to return for evaluation, the most recent clinical record was utilized. Among the 36 subjects initially randomized, 21 returned for evaluation (11 BA, 10 surgery). The average time since initial intervention to evaluation for all subjects was 10.6±4.7 years for BA subjects and 11.3±3.7 years for surgical subjects. Resting blood pressure, CoA gradient, exercise performance, MRI analysis of the aortic arch, and need for repeat interventions were not different for the 2 treatment strategies. There was a higher incidence of aneurysm formation (35% versus 0%) and a greater difference in blood pressure between the right and left legs with exercise among BA subjects. Some aneurysms developed late, first being detected more than 5 years after the initial intervention. Only 50% of BA subjects remained free of both aneurysm formation and repeat intervention compared with 87.5% of surgical subjects (P=0.03).

Conclusions— BA for the treatment of childhood CoA is associated with a higher incidence of aneurysm formation and iliofemoral artery injury than surgery. These differences should be considered when undertaking treatment for native CoA during childhood.

Key Words: coarctation • balloon • angioplasty • surgery

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Leaving Neverland: A Randomized Trial for Coarctation Shows Pediatric Interventional Cardiology Is Growing Up

Audrey C. Marshall and James E. Lock
Circulation 2005 111: 3347-3348. [Full Text]

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