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Circulation. 2004;110:588-636
doi: 10.1161/01.CIR.0000134791.68010.FA
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(Circulation. 2004;110:588-636.)
© 2004 American Heart Association, Inc.


ACC/AHA Practice Guidelines

ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary

A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction)

Developed in Collaboration With the Canadian Cardiovascular Society    Writing Committee Members: Elliott M. Antman, MD, FACC, FAHA, Chair; Daniel T. Anbe, MD, FACC, FAHA; Paul Wayne Armstrong, MD, FACC, FAHA; Eric R. Bates, MD, FACC, FAHA; Lee A. Green, MD, MPH; Mary Hand, MSPH, RN, FAHA; Judith S. Hochman, MD, FACC, FAHA; Harlan M. Krumholz, MD, FACC, FAHA; Frederick G. Kushner, MD, FACC, FAHA; Gervasio A. Lamas, MD, FACC; Charles J. Mullany, MB, MS, FACC; Joseph P. Ornato, MD, FACC, FAHA; David L. Pearle, MD, FACC, FAHA; Michael A. Sloan, MD, FACC; Sidney C. Smith, Jr, MD, FACC, FAHA

Task Force Members: Elliott M. Antman, MD, FACC, FAHA, Chair; Sidney C. Smith, Jr, MD, FACC, FAHA, Vice-chair; Joseph S. Alpert, MD, FACC, FAHA*; Jeffrey L. Anderson, MD, FACC, FAHA; David P. Faxon, MD, FACC, FAHA; Valentin Fuster, MD, PhD, FACC, FAHA; Raymond J. Gibbons, MD, FACC, FAHA*,{dagger}; Gabriel Gregoratos, MD, FACC, FAHA*; Jonathan L. Halperin, MD, FACC, FAHA; Loren F. Hiratzka, MD, FACC, FAHA; Sharon Ann Hunt, MD, FACC, FAHA; Alice K. Jacobs, MD, FACC, FAHA; Joseph P. Ornato, MD, FACC, FAHA


An extract of the first 250 words of the full text is provided, because this article has no abstract.
 


*    Table of Contents
 

I. Introduction
II. Pathology 590
   A. Epidemiology 590
III. Management Before STEMI 590
   A. Identification of Patients at Risk of STEMI 590
   B. Patient Education for Early Recognition and Response to STEMI 590
IV. Onset of STEMI 592
   A. Out-of-Hospital Cardiac Arrest 592
V. Prehospital Issues 592
   A. Emergency Medical Services Systems 592
   B. Prehospital Chest Pain Evaluation and Treatment 592
   C. Prehospital Fibrinolysis 592
   D. Prehospital Destination Protocols 593
VI. Initial Recognition and Management in the Emergency Department 593
   A. Optimal Strategies for Emergency Department Triage 593
   B. Initial Patient Evaluation 593
      1. History 595
      2. Physical Examination 595
      3. Electrocardiogram 595
      4. Laboratory Examinations 595
      5. Biomarkers of Cardiac Damage 595
         a. Bedside Testing for Serum Cardiac Biomarkers 596
      6. Imaging 596
   C. Management 596
      1. Routine Measures 596
         a. Oxygen 596
         b. Nitroglycerin 596
         c. Analgesia 596
         d. Aspirin 597
         e. Beta-Blockers 597
         f. Reperfusion 597
            • General Concepts 597
            • Selection of Reperfusion Strategy 597
            • Pharmacological Reperfusion 598
            • Percutaneous Coronary Intervention 600
            • Acute Surgical Reperfusion 605
            • Patients With STEMI Not Receiving Reperfusion 605
            • Assessment of Reperfusion 605
            • Ancillary Therapy 605
            • Other Pharmacological Measures 607
VII. Hospital Management 608
   A. Location 608
      1. Coronary Care Unit 608
      2. Stepdown Unit 608
   B. Early, General Measures 609
      1. Level of Activity 609
      2. Diet 609
      3. Patient Education in the Hospital Setting 609
      4. Analgesia/Anxiolytics 609
   C. Risk Stratification During Early Hospital Course 609
   D. Medication Assessment 610
      1. Beta Blockers . . . [Full Text of this Article]




Related Internet Resources:

2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction

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C. Asseburg, Y. Bravo Vergel, S. Palmer, E. Fenwick, M. de Belder, K. R Abrams, and M. Sculpher
Assessing the effectiveness of primary angioplasty compared with thrombolysis and its relationship to time delay: a Bayesian evidence synthesis
Heart, October 1, 2007; 93(10): 1244 - 1250.
[Abstract] [Full Text] [PDF]


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Postgrad. Med. J.Home page
W. H Ibrahim
Recent advances and controversies in adult cardiopulmonary resuscitation
Postgrad. Med. J., October 1, 2007; 83(984): 649 - 654.
[Abstract] [Full Text] [PDF]


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J Am Coll CardiolHome page
W. E. Boden, K. Eagle, and C. B. Granger
Reperfusion Strategies in Acute ST-Segment Elevation Myocardial Infarction: A Comprehensive Review of Contemporary Management Options
J. Am. Coll. Cardiol., September 4, 2007; 50(10): 917 - 929.
[Abstract] [Full Text] [PDF]


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Diabetes and Vascular Disease ResearchHome page
S. V Parikh, S. M Abdullah, E. C Keeley, J. E Cigarroa, T. A Addo, J. J Warner, A. Khera, J. A De Lemos, and D. K McGuire
Effect of glucose-insulin-potassium (GIK) infusion on biomarkers of cardiovascular risk in ST elevation myocardial infarction (STEMI): insight into the failure of GIK
Diabetes and Vascular Disease Research, September 1, 2007; 4(3): 222 - 225.
[Abstract] [PDF]


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Eur Heart JHome page
H. Thiele, R. W. Smalling, and G. C. Schuler
Percutaneous left ventricular assist devices in acute myocardial infarction complicated by cardiogenic shock
Eur. Heart J., September 1, 2007; 28(17): 2057 - 2063.
[Abstract] [Full Text] [PDF]


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CirculationHome page
T. D. Henry, S. W. Sharkey, M. N. Burke, I. J. Chavez, K. J. Graham, C. R. Henry, D. L. Lips, J. D. Madison, K. M. Menssen, M. R. Mooney, et al.
A Regional System to Provide Timely Access to Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
Circulation, August 14, 2007; 116(7): 721 - 728.
[Abstract] [Full Text] [PDF]


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Arch Intern MedHome page
R. Shah, J. Selter, Y. Wang, M. Greenspan, and J. M. Foody
Association of Troponin Status With Guideline-Based Management of Acute Myocardial Infarction in Older Persons
Arch Intern Med, August 13, 2007; 167(15): 1621 - 1628.
[Abstract] [Full Text] [PDF]


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Emerg. Med. J.Home page
B. A Afolabi, G. M Novaro, S. L Pinski, K. R Fromkin, and H. S Bush
Use of the prehospital ECG improves door-to-balloon times in ST segment elevation myocardial infarction irrespective of time of day or day of week
Emerg. Med. J., August 1, 2007; 24(8): 588 - 591.
[Abstract] [Full Text] [PDF]


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HypertensionHome page
C. Rosendorff, H. R. Black, C. P. Cannon, B. J. Gersh, J. Gore, J. L. Izzo Jr, N. M. Kaplan, C. M. O'Connor, P. T. O'Gara, and S. Oparil
REPRINT Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention
Hypertension, August 1, 2007; 50(2): e28 - e55.
[Full Text] [PDF]


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CirculationHome page
C. B. Granger, T. D. Henry, W. E. R. Bates, B. Cercek, W. D. Weaver, and D. O. Williams
Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: The Primary Percutaneous Coronary Intervention (ST-Elevation Myocardial Infarction Receiving) Hospital Perspective
Circulation, July 10, 2007; 116(2): e55 - e59.
[Full Text] [PDF]


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BMJHome page
A Khavandi, K Potts, and P R Walker
Advising patients on dealing with acute chest pain
BMJ, July 7, 2007; 335(7609): 3 - 4.
[Full Text] [PDF]


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Eur Heart JHome page
T. J. Kiernan, H. H. Ting, and B. J. Gersh
Facilitated percutaneous coronary intervention: current concepts, promises, and pitfalls
Eur. Heart J., July 1, 2007; 28(13): 1545 - 1553.
[Abstract] [Full Text] [PDF]


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CMAJHome page
J. S. de Villiers, T. Anderson, J. D. McMeekin, R. C.M. Leung, M. Traboulsi, and for the Foothills Interventional Cardiology Servic
Expedited transfer for primary percutaneous coronary intervention: a program evaluation
Can. Med. Assoc. J., June 19, 2007; 176(13): 1833 - 1838.
[Abstract] [Full Text] [PDF]


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EuropaceHome page
R. K. Riezebos, K. de Man, M. S. Patterson, and G. S. de Ruiter
A bridge to Brugada
Europace, June 1, 2007; 9(6): 398 - 400.
[Abstract] [Full Text] [PDF]


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CirculationHome page
C. Rosendorff, H. R. Black, C. P. Cannon, B. J. Gersh, J. Gore, J. L. Izzo Jr, N. M. Kaplan, C. M. O'Connor, P. T. O'Gara, and S. Oparil
Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention
Circulation, May 29, 2007; 115(21): 2761 - 2788.
[Full Text] [PDF]


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JAMAHome page
K. Parakh, D. E. Bush, R. C. Ziegelstein, B. D. Thombs, and J. A. Fauerbach
Mortality and Adherence to Pharmacotherapy After Acute Myocardial Infarction
JAMA, May 2, 2007; 297(17): 1877 - 1877.
[Full Text] [PDF]


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JAMAHome page
K. A. A. Fox, P. G. Steg, K. A. Eagle, S. G. Goodman, F. A. Anderson Jr, C. B. Granger, M. D. Flather, A. Budaj, A. Quill, J. M. Gore, et al.
Decline in Rates of Death and Heart Failure in Acute Coronary Syndromes, 1999-2006
JAMA, May 2, 2007; 297(17): 1892 - 1900.
[Abstract] [Full Text] [PDF]


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Mayo Clin Proc.Home page
G. E. Kikano and M. T. Brown
Antiplatelet Therapy for Atherothrombotic Disease: An Update for the Primary Care Physician
Mayo Clin. Proc., May 1, 2007; 82(5): 583 - 593.
[Abstract] [Full Text] [PDF]


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NEJMHome page
J. R. Anderson, N. Nagajothi, J.-L. E. Velazquez-Cecena, S. Khosla, B. Wong, O. Erdogan, L. De Luca, F. Tomai, D. Chua, A. Lo, et al.
Persistent Coronary Occlusion after Myocardial Infarction
N. Engl. J. Med., April 19, 2007; 356(16): 1681 - 1684.
[Full Text] [PDF]


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JAMAHome page
The TRIUMPH Investigators
Effect of Tilarginine Acetate in Patients With Acute Myocardial Infarction and Cardiogenic Shock: The TRIUMPH Randomized Controlled Trial
JAMA, April 18, 2007; 297(15): 1657 - 1666.
[Abstract] [Full Text] [PDF]


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NEJMHome page
D. C. Brown, S. Szabo, T. Oikonomopoulos, H. M. Hoffmeister, A. S. Kashyap, S. Kashyap, K. P. Anand, E. C. Keeley, and L. D. Hillis
Primary percutaneous coronary intervention.
N. Engl. J. Med., April 12, 2007; 356(15): 1588 - 1589.
[Full Text] [PDF]


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NEJMHome page
W. E. Boden, R. A. O'Rourke, K. K. Teo, P. M. Hartigan, D. J. Maron, W. J. Kostuk, M. Knudtson, M. Dada, P. Casperson, C. L. Harris, et al.
Optimal Medical Therapy with or without PCI for Stable Coronary Disease
N. Engl. J. Med., April 12, 2007; 356(15): 1503 - 1516.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
A. Lerman, D. R. Holmes, J. Herrmann, and B. J. Gersh
Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both?
Eur. Heart J., April 1, 2007; 28(7): 788 - 797.
[Abstract] [Full Text] [PDF]


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JAMAHome page
J. N. Rasmussen, A. Chong, and D. A. Alter
Relationship Between Adherence to Evidence-Based Pharmacotherapy and Long-term Mortality After Acute Myocardial Infarction
JAMA, January 10, 2007; 297(2): 177 - 186.
[Abstract] [Full Text] [PDF]


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Arch Intern MedHome page
P. G. Steg, J. Lopez-Sendon, E. Lopez de Sa, S. G. Goodman, J. M. Gore, F. A. Anderson Jr, D. Himbert, J. Allegrone, F. Van de Werf, and for the GRACE Investigators
External Validity of Clinical Trials in Acute Myocardial Infarction
Arch Intern Med, January 8, 2007; 167(1): 68 - 73.
[Abstract] [Full Text] [PDF]


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NEJMHome page
E. C. Keeley and L. D. Hillis
Primary PCI for Myocardial Infarction with ST-Segment Elevation
N. Engl. J. Med., January 4, 2007; 356(1): 47 - 54.
[Full Text] [PDF]


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CirculationHome page
D. C. Goff Jr, L. Brass, L. T. Braun, J. B. Croft, J. D. Flesch, F. G.R. Fowkes, Y. Hong, V. Howard, S. Huston, S. F. Jencks, et al.
Essential Features of a Surveillance System to Support the Prevention and Management of Heart Disease and Stroke: A Scientific Statement From the American Heart Association Councils on Epidemiology and Prevention, Stroke, and Cardiovascular Nursing and the Interdisciplinary Working Groups on Quality of Care and Outcomes Research and Atherosclerotic Peripheral Vascular Disease
Circulation, January 2, 2007; 115(1): 127 - 155.
[Full Text] [PDF]