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(Circulation. 2004;110:e550-e553.)
© 2004 American Heart Association, Inc.

AHA Conference Proceedings

CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease

Application to Clinical and Public Health Practice: Report From the Clinical Practice Discussion Group

Sidney C. Smith, Jr, MD, Chair; Jeffrey L. Anderson, MD, Co-Chair; Richard O. Cannon, III, MD; Yazid Y. Fadl, MD; Wolfgang Koenig, MD; Peter Libby, MD; Steven E. Lipshultz, MD; George A. Mensah, MD; Paul M Ridker, MD; Robert Rosenson, MD

Key Words: AHA Scientific Statements • atherosclerosis • inflammation • meta-analysis • prevention

An extract of the first 250 words of the full text is provided, because this article has no abstract.

The Centers for Disease Control and Prevention/American Heart Association (CDC/AHA) Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice was convened on March 14 and 15, 2002, in Atlanta, Ga, to examine the selection and use of inflammatory markers to predict cardiovascular disease (CVD) risk. Three discussion groups on issues related to laboratory, clinical, and population science were organized. The present report contains a summary of the discussions and recommendations of the clinical practice discussion group.

Recommendations for Clinical Practice

1. High-sensitivity C-reactive protein (hsCRP) is an independent marker of risk that may be used at the discretion of the physician in patients judged by global risk assessment to be at intermediate risk (10% to 20% risk of coronary heart disease [CHD] per 10 years) for cardiovascular disease (CVD). hsCRP may help direct further evaluation and therapy in the primary prevention of CVD. The benefits of such therapy based on this strategy remain uncertain. (Class IIa, Level of Evidence: B)
   
2. hsCRP is an independent marker of risk and may be used at the discretion of the physician as part of a global coronary risk assessment in adults without known CVD. The benefits of this strategy remain uncertain. (Class IIb, Level of Evidence: C)
   
3. hsCRP levels may be useful in motivating patients to improve their lifestyle behaviors. The benefits of this strategy remain uncertain. (Class IIb, Level of Evidence: C)
   
4. Patients with persistently unexplained marked elevation of hsCRP (10 mg/L) after repeated testing should be evaluated for noncardiovascular causes. . . . [Full Text of this Article]

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