(Circulation. 2004;110:3378-3383.)
© 2004 American Heart Association, Inc.
Basic Science for Clinicians |
From the Division of Hematology/Oncology, Department of Radiology, and Molecular Imaging Center, Beth Israel Deaconess Medical Center (J.V.F.); the Cardiology Laboratory of Integrative Physiology & Imaging, Cardiovascular Research Center, Massachusetts General Hospital (R.J.H.); and Harvard Medical School (J.V.F., R.J.H.), Boston, Mass.
Correspondence to John V. Frangioni, MD, PhD, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, SL-B05, Boston, MA 02215. E-mail jfrangio{at}bidmc.harvard.edu
Abstract
Various stem cells hold promise for the treatment of human cardiovascular disease. Regardless of stem cell origin, future clinical trials will require that the location and number of such cells be tracked in vivo, over long periods of time. The problem of tracking small numbers of cells in the body is a difficult one, and an optimal solution does not yet exist. We review the many contrast agents and detectors that have been proposed for stem cell tracking during clinical trials, define the characteristics of an ideal imaging technology, and suggest future directions for research.
Key Words: stem cells imaging trials radiology
This article has been cited by other articles:
![]() |
J. Terrovitis, M. Stuber, A. Youssef, S. Preece, M. Leppo, E. Kizana, M. Schar, G. Gerstenblith, R. G. Weiss, E. Marban, et al. Magnetic Resonance Imaging Overestimates Ferumoxide-Labeled Stem Cell Survival After Transplantation in the Heart Circulation, March 25, 2008; 117(12): 1555 - 1562. [Abstract] [Full Text] [PDF] |
||||
![]() |
C.-P. Chen, M.-Y. Lee, J.-P. Huang, J. D. Aplin, Y.-H. Wu, C.-S. Hu, P.-C. Chen, H. Li, S.-M. Hwang, S.-H. Liu, et al. Trafficking of Multipotent Mesenchymal Stromal Cells from Maternal Circulation Through the Placenta Involves Vascular Endothelial Growth Factor Receptor-1 and Integrins Stem Cells, February 1, 2008; 26(2): 550 - 561. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Valina, K. Pinkernell, Y.-H. Song, X. Bai, S. Sadat, R. J. Campeau, T. H. Le Jemtel, and E. Alt Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction Eur. Heart J., November 1, 2007; 28(21): 2667 - 2677. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. A. Jaffer, P. Libby, and R. Weissleder Molecular Imaging of Cardiovascular Disease Circulation, August 28, 2007; 116(9): 1052 - 1061. [Full Text] [PDF] |
||||
![]() |
A. B. Rosen, D. J. Kelly, A. J. T. Schuldt, J. Lu, I. A. Potapova, S. V. Doronin, K. J. Robichaud, R. B. Robinson, M. R. Rosen, P. R. Brink, et al. Finding Fluorescent Needles in the Cardiac Haystack: Tracking Human Mesenchymal Stem Cells Labeled with Quantum Dots for Quantitative In Vivo Three-Dimensional Fluorescence Analysis Stem Cells, August 1, 2007; 25(8): 2128 - 2138. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. L.M.A. Beeres, F. M. Bengel, J. Bartunek, D. E. Atsma, J. M. Hill, M. Vanderheyden, M. Penicka, M. J. Schalij, W. Wijns, and J. J. Bax Role of Imaging in Cardiac Stem Cell Therapy J. Am. Coll. Cardiol., March 20, 2007; 49(11): 1137 - 1148. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction Eur. Heart J., May 1, 2006; 27(9): 1114 - 1122. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Cao, S. Lin, X. Xie, P. Ray, M. Patel, X. Zhang, M. Drukker, S. J. Dylla, A. J. Connolly, X. Chen, et al. In Vivo Visualization of Embryonic Stem Cell Survival, Proliferation, and Migration After Cardiac Delivery Circulation, February 21, 2006; 113(7): 1005 - 1014. [Abstract] [Full Text] [PDF] |
||||
|
Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search Copyright © 2004 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. |