Published online before print January 5, 2004, doi: 10.1161/01.CIR.0000108928.25690.94
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2004;109:201-206.)
© 2004 American Heart Association, Inc.
Clinical Investigation and Reports |
Effects of Carvedilol on Left Ventricular Remodeling After Acute Myocardial Infarction
The CAPRICORN Echo Substudy
From the Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand, and Hospital Gregorio Maranon (J.L.-S.), Madrid, Spain.
Correspondence to Dr R.N. Doughty, Senior Lecturer in Cardiology, Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand. E-mail r.doughty{at}auckland.ac.nz
Received June 18, 2003; revision received October 6, 2003; accepted October 6, 2003.
Background— The CAPRICORN trial has shown that carvedilol improved outcome in patients with left ventricular dysfunction after acute myocardial infarction treated with ACE inhibitors. The aim of this substudy was to determine the effects of carvedilol on left ventricular remodeling in this patient group.
Methods and Results— Patients entering the CAPRICORN trial from 13 centers in New Zealand, Australia, and Spain were recruited for this echocardiographic substudy. In 127 patients, quantitative 2D echocardiography was performed according to a standard protocol before randomization and repeated after 1, 3, and 6 months of treatment with carvedilol or placebo. Left ventricular volumes, ejection fraction (Simpson’s method), and wall motion score index were determined in a blinded analysis at the Core Echo Laboratory. At 6 months, left ventricular end systolic volume was 9.2 mL less in the carvedilol group than in the placebo group (P=0.023), and left ventricular ejection fraction was 3.9% higher (P=0.015). Left ventricular end diastolic volume and wall motion score index were not statistically different between the 2 groups at 6 months.
Conclusions— In patients with left ventricular dysfunction after acute myocardial infarction treated with ACE inhibitors, carvedilol had a beneficial effect on ventricular remodeling, which may, in part, mediate the substantial clinical beneficial effects of carvedilol in this patient population.
Key Words: remodeling • infarction • ventricles • echocardiography
This article has been cited by other articles:
 |
|
 |
|
  R. E. Goldstein and M. C.P. Haigney Heart-rate reduction and {beta}-blockade in early post-infarction cardiac remodelling Cardiovasc Res, July 1, 2008; 79(1): 5 - 6. [Full Text] [PDF]
|
|
|
|
 |
|
 Meta-Analysis Research Group in Echocardiography ( Independent Prognostic Importance of a Restrictive Left Ventricular Filling Pattern After Myocardial Infarction: An Individual Patient Meta-Analysis: Meta-Analysis Research Group in Echocardiography Acute Myocardial Infarction Circulation, May 20, 2008; 117(20): 2591 - 2598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Schocken, E. J. Benjamin, G. C. Fonarow, H. M. Krumholz, D. Levy, G. A. Mensah, J. Narula, E. S. Shor, J. B. Young, and Y. Hong Prevention of Heart Failure: A Scientific Statement From the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, May 13, 2008; 117(19): 2544 - 2565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Albert and C. Lewis Recognizing and Managing Asymptomatic Left Ventricular Dysfunction: After Myocardial Infarction Crit. Care Nurse, April 1, 2008; 28(2): 20 - 37. [Full Text] [PDF]
|
|
|
|
|
|
D. Seo and J. M. Hare The Transforming Growth Factor-{beta}/Smad3 Pathway: Coming of Age as a Key Participant in Cardiac Remodeling Circulation, November 6, 2007; 116(19): 2096 - 2098. [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Mollema, S. S. Liem, M. S. Suffoletto, G. B. Bleeker, B. L. van der Hoeven, N. R. van de Veire, E. Boersma, E. R. Holman, E. E. van der Wall, M. J. Schalij, et al. Left Ventricular Dyssynchrony Acutely After Myocardial Infarction Predicts Left Ventricular Remodeling J. Am. Coll. Cardiol., October 16, 2007; 50(16): 1532 - 1540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Dargie, P. R. Hildebrandt, G. A.J. Riegger, J. J.V. McMurray, S. O. McMorn, J. N. Roberts, A. Zambanini, and J. P.H. Wilding A Randomized, Placebo-Controlled Trial Assessing the Effects of Rosiglitazone on Echocardiographic Function and Cardiac Status in Type 2 Diabetic Patients With New York Heart Association Functional Class I or II Heart Failure J. Am. Coll. Cardiol., April 24, 2007; 49(16): 1696 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gheorghiade, G. Sopko, L. De Luca, E. J. Velazquez, J. D. Parker, P. F. Binkley, Z. Sadowski, K. S. Golba, D. L. Prior, J. L. Rouleau, et al. Navigating the Crossroads of Coronary Artery Disease and Heart Failure Circulation, September 12, 2006; 114(11): 1202 - 1213. [Full Text] [PDF]
|
|
|
|
|
|
M. P. Hudson, P. W. Armstrong, W. Ruzyllo, J. Brum, L. Cusmano, P. Krzeski, R. Lyon, M. Quinones, P. Theroux, D. Sydlowski, et al. Effects of Selective Matrix Metalloproteinase Inhibitor (PG-116800) to Prevent Ventricular Remodeling After Myocardial Infarction: Results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) Trial J. Am. Coll. Cardiol., July 4, 2006; 48(1): 15 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Hays, R. L. Sacco, T. Rundek, R. R. Sciacca, Z. Jin, R. Liu, S. Homma, and M. R. Di Tullio Left Ventricular Systolic Dysfunction and the Risk of Ischemic Stroke in a Multiethnic Population Stroke, July 1, 2006; 37(7): 1715 - 1719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Goldberg and M. Jessup Stage B Heart Failure: Management of Asymptomatic Left Ventricular Systolic Dysfunction Circulation, June 20, 2006; 113(24): 2851 - 2860. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Silke Beta-blockade in CHF: pathophysiological considerations Eur. Heart J. Suppl., June 1, 2006; 8(suppl_C): C13 - C18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ponikowski Rationale and design of CIBIS III Eur. Heart J. Suppl., June 1, 2006; 8(suppl_C): C35 - C42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fujioka, K.-i. Kawabata, Y. Saito, T. Kobayashi, T. Nakamura, Y. Kodama, H. Takano, J.-e. Obata, Y. Kitta, K. Umetani, et al. Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2409 - H2416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferrazzi, M. L.S. Matteucci, M. Merlo, A. Iacovoni, G. Rescigno, M. Bottai, P. Parrella, L. Lorini, M. Senni, and A. Gavazzi Surgical ventricular reverse remodeling in severe ischemic dilated cardiomyopathy: The relevance of the left ventricular equator as a prognostic factor J. Thorac. Cardiovasc. Surg., February 1, 2006; 131(2): 357 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Hohnloser Ventricular Arrhythmias: Antiadrenergic Therapy for the Patient with Coronary Artery Disease Journal of Cardiovascular Pharmacology and Therapeutics, October 1, 2005; 10(4_suppl): S23 - S31. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Levine and E. Schwammenthal Ischemic Mitral Regurgitation on the Threshold of a Solution: From Paradoxes to Unifying Concepts Circulation, August 2, 2005; 112(5): 745 - 758. [Full Text] [PDF]
|
|
|
|
|
|
F. See, W. Thomas, K. Way, A. Tzanidis, A. Kompa, D. Lewis, S. Itescu, and H. Krum p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat J. Am. Coll. Cardiol., October 19, 2004; 44(8): 1679 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pieske Reverse remodeling in heart failure - fact or fiction? Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D66 - D78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. SoRelle Cardiovascular News Circulation, January 20, 2004; 109 (2): e9002 - e9003. [Full Text]
|
|