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(Circulation. 2004;109:1686-1692.)
© 2004 American Heart Association, Inc.

Basic Science Reports

Comparing the Efficacy and Safety of a Novel Monophasic Waveform Delivered by the Passive Implantable Atrial Defibrillator With Biphasic Waveforms in Cardioversion of Atrial Fibrillation

Ganesh Manoharan, MD; Noel Evans, PhD; Desmond Allen, MD; John Anderson, DPhil; Jennifer Adgey, MD

From the Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast (G.M., D.A., J. Adgey); Department of Engineering, University of Ulster, Jordanstown (G.M., N.E., J. Anderson); and Queens University of Belfast, Belfast (G.M., D.A.), UK.

Correspondence to Dr Ganesh Manoharan, Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Rd, Belfast BT12 6BA, UK. E-mail gmanoharan{at}msn.com

Received October 6, 2003; revision received December 17, 2003; accepted December 30, 2003.

Background— The passive implantable atrial defibrillator (PIAD) (with no battery or discharging capacitor and powered transcutaneously by radio-frequency energy) delivering a novel monophasic low-tilt waveform is more efficacious than the standard monophasic waveform at atrial defibrillation. Standard biphasic (STB) waveforms, however, are more efficacious and safer than monophasic waveforms. This study compared the efficacy and safety of the PIAD waveform with biphasic waveforms.

Methods and Results— Sustained atrial fibrillation (AF) was induced by rapid atrial pacing. Cardioversion was attempted via 2 atrial defibrillation leads. The efficacy of the PIAD was compared with 3 biphasic waveforms (standard, single rounded, and double rounded) at varying voltage settings in 10 pigs. After a synchronized shock, hemodynamic changes between the PIAD, standard biphasic, and monophasic waveforms were compared at 1.5 and 3.0 J in 12 pigs. Myocardial injury (biochemical and histological) after ten 5-J PIAD shocks was compared with a no-shock group in 14 pigs. The PIAD 100-V setting was significantly more efficacious than the STB (100/–50 V: 100% [1.88±0.02 J] versus 90% [0.89±0.0 J]; P=0.025). No arrhythmic, hemodynamic, or myocardial injury was observed with the PIAD waveform.

Conclusions— Defibrillation with the PIAD is more efficacious than with the STB waveform and appears safe. This device could provide a more effective option for cardioversion.

Key Words: arrhythmia • fibrillation • cardioversion

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