Published online before print December 8, 2003, doi: 10.1161/01.CIR.0000105721.71640.DA
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(Circulation. 2004;109:120-124.)
© 2004 American Heart Association, Inc.
Basic Science Reports |
Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats
From the Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Japan (M.L., C.Z., T.S., T.K., M.S., K.S.); and the Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan (T.S.).
Correspondence to Takayuki Sato, MD, Department of Cardiovascular Control, Kochi Medical School, Nankoku, Kochi 783-8505, Japan. E-mail tacsato-kochimed{at}umin.ac.jp
Received January 16, 2003; de novo received June 4, 2003; revision received August 25, 2003; accepted August 26, 2003.
Background— Diminished cardiac vagal activity and higher heart rate predict a high mortality rate of chronic heart failure (CHF) after myocardial infarction. We investigated the effects of chronic electrical stimulation of the vagus nerve on cardiac remodeling and long-term survival in an animal model of CHF after large myocardial infarction.
Methods and Results— Two weeks after the ligation of the left coronary artery, surviving rats were randomized to vagal- and sham-stimulated groups. Using an implantable miniature radio-controlled electrical stimulator, we stimulated the right vagal nerve of CHF rats for 6 weeks. The intensity of electrical stimulation was adjusted for each rat, so that the heart rate was lowered by 20 to 30 beats per minute. The treated rats had significantly lower left ventricular end-diastolic pressure (17.1±5.9 versus 23.5±4.2 mm Hg, P<0.05) and higher maximum dp/dt of left ventricular pressure (4152±237 versus 2987±192 mm Hg/s, P<0.05) than the untreated rats. Improvement of cardiac pumping function was accompanied by a decrease in normalized biventricular weight (2.75±0.25 versus 3.14±0.22 g/kg, P<0.01). Although the 140-day survival of the untreated group was only half, vagal stimulation markedly improved the survival rate (86% versus 50%, P=0.008). Vagal stimulation therapy achieved a 73% reduction in a relative risk ratio of death.
Conclusions— Vagal nerve stimulation markedly improved the long-term survival of CHF rats through the prevention of pumping failure and cardiac remodeling.
Key Words: electrical stimulation • heart failure • myocardial infarction • remodeling • vagus nerve
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