(Circulation. 2003;108:2613.)
© 2003 American Heart Association, Inc.
Clinician Update |
From the Division of Cardiology, St. Michaels Hospital, The University of Toronto (N.P.F., M.K., D.J.S.), and the Division of Cardiac Surgery, Toronto General Hospital (S.V.), Toronto, Ontario, Canada.
Correspondence to Duncan J. Stewart, MD, St. Michaels Hospital, 30 Bond St, Toronto, Ontario, Canada M5B 1W8. E-mail stewartd@smh.toronto.on.ca
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
| Introduction |
|---|
Since recognition of the central role of angiogenic factors in tumor growth over 30 years ago,1 physiological and pathological angiogenesis has been implicated in diverse conditions, including vascular insufficiency, inflammation, and diabetic retinopathy. Despite considerable advances in medical therapy and improvements in revascularization procedures for coronary artery disease, a substantial proportion of patients suffer from refractory angina or recurrent myocardial ischemia requiring hospitalization. In the past decade, a number of clinical trials have examined the role of therapeutic angiogenesis for myocardial ischemia. In this article, we focus on the fundamental mechanisms of angiogenesis and discuss current and future issues in therapeutic coronary angiogenesis.
| Principles of Angiogenesis |
|---|
This article has been cited by other articles:
![]() |
T. Higuchi, F. M. Bengel, S. Seidl, P. Watzlowik, H. Kessler, R. Hegenloh, S. Reder, S. G. Nekolla, H. J. Wester, and M. Schwaiger Assessment of {alpha}v{beta}3 integrin expression after myocardial infarction by positron emission tomography Cardiovasc Res, May 1, 2008; 78(2): 395 - 403. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Burke, I. Hickie, M. Breakspear, and J. Gotz Possibilities for the prevention and treatment of cognitive impairment and dementia The British Journal of Psychiatry, May 1, 2007; 190(5): 371 - 372. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. T Grazul-Bilska, C. Navanukraw, M. L. Johnson, D. A Arnold, L. P Reynolds, and D. A Redmer Expression of endothelial nitric oxide synthase in the ovine ovary throughout the estrous cycle. Reproduction, October 1, 2006; 132(4): 579 - 587. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. D. Zhao, D. W. Courtman, D. S. Ng, M. J. Robb, Y. P. Deng, J. Trogadis, R. N. N. Han, and D. J. Stewart Microvascular Regeneration in Established Pulmonary Hypertension by Angiogenic Gene Transfer Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 182 - 189. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Hua, L. W. Dobrucki, M. M. Sadeghi, J. Zhang, B. N. Bourke, P. Cavaliere, J. Song, C. Chow, N. Jahanshad, N. van Royen, et al. Noninvasive Imaging of Angiogenesis With a 99mTc-Labeled Peptide Targeted at {alpha}v{beta}3 Integrin After Murine Hindlimb Ischemia Circulation, June 21, 2005; 111(24): 3255 - 3260. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Wagatsuma, H. Tamaki, and F. Ogita Capillary supply and gene expression of angiogenesis-related factors in murine skeletal muscle following denervation Exp Physiol, May 1, 2005; 90(3): 403 - 409. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Sivakumar, L. E. Harry, and E. M. Paleolog Modulating Angiogenesis: More vs Less JAMA, August 25, 2004; 292(8): 972 - 977. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. B. Keller and L. Lemberg Prinzmetal's Angina Am. J. Crit. Care., July 1, 2004; 13(4): 350 - 354. [Full Text] [PDF] |
||||
|
Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search Copyright © 2003 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. |