Circulation. 2003;108:2543-2549
Published online before print November 10, 2003, doi: 10.1161/01.CIR.0000100560.46946.EA
Published online before print November 10, 2003, doi: 10.1161/01.CIR.0000100560.46946.EA
(Circulation. 2003;108:2543.)
© 2003 American Heart Association, Inc.
AHA Scientific Statement |
Case Definitions for Acute Coronary Heart Disease in Epidemiology and Clinical Research Studies
A Statement From the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute
Key Words: AHA Scientific Statements • myocardial infarction • coronary disease • epidemiology • diagnosis
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
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Introduction |
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An epidemic of coronary heart disease (CHD) began during the 20th century in most industrialized countries, where CHD is a leading cause of mortality among adults.1 Developing countries show the beginnings of the same epidemic. Reliable information on population incidence, prevalence, and case-fatality rates of CHD is essential to understanding, treating, and controlling the epidemic but is generally unavailable. Consistent and universal definitions of cases of CHD allow the determination of rates and comparisons within and between populations. These case definitions are essential to epidemiological studies and other research, such as clinical trials, quality assurance, and economic analysis of healthcare costs. The need for standardization is clear, and this statement recommends updated definitions.
Definitions of cases for epidemiology studies and clinical trials in acute CHD rest on World Health Organization (WHO) (1959) and American Heart Association (1964) reports, followed by the WHO European AMI Registry criteria.2,3 Myocardial infarction (MI) is based on cardiac symptoms, ECG changes, and/or elevation in biomarkers. This basic system has been widely used but variably interpreted, resulting in a lack of comparability among and within studies. Further specification and working definitions of CHD come from the Framingham Study.4 The WHO criteria were revised in a joint report with the International Society and Federation of Cardiology in 1979.5 More recently, the WHO MONICA Study6 and other surveillance and intervention studies, such as the Lipid Research Clinics in the United States,7 have modified further the definition of CHD cases. These changes are usually based on a greater specification
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Writing Committee Members, E. M. Antman, D. T. Anbe, P. W. Armstrong, E. R. Bates, L. A. Green, M. Hand, J. S. Hochman, H. M. Krumholz, F. G. Kushner, et al. ACC/AHA guidelines for the management of patients with ST-Elevation myocardial infarction--executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction) J. Am. Coll. Cardiol., August 4, 2004; 44(3): 671 - 719. [Full Text] [PDF]
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E. M. Antman, D. T. Anbe, P. W. Armstrong, E. R. Bates, L. A. Green, M. Hand, J. S. Hochman, H. M. Krumholz, F. G. Kushner, G. A. Lamas, et al. ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction) Circulation, August 3, 2004; 110(5): 588 - 636. [Full Text] [PDF]
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F. S. Apple and M. M. Murakami Serum 99th Percentile Reference Cutoffs for Seven Cardiac Troponin Assays Clin. Chem., August 1, 2004; 50(8): 1477 - 1479. [Full Text] [PDF]
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