Published online before print October 6, 2003, doi: 10.1161/01.CIR.0000092891.55157.A7
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(Circulation. 2003;108:2107.)
© 2003 American Heart Association, Inc.
Clinical Investigation and Reports |
Immunoglobulin M Type of Autoantibodies to Oxidized Low-Density Lipoprotein Has an Inverse Relation to Carotid Artery Atherosclerosis
From the Department of Internal Medicine (J.K., Y.A.K., S.H.), Biocenter Oulu (J.K., Y.A.K., S.H.), and Department of Diagnostic Radiology (M.P.), University of Oulu, Finland.
Correspondence to Jarkko Karvonen, Department of Internal Medicine, University of Oulu, P.O. Box 5000, FIN-90014, University of Oulu, Finland. E-mail jakarvon{at}paju.oulu.fi
Received November 15, 2002; de novo received May 20, 2003; revision received July 2, 2003; accepted July 8, 2003.
Background— Lipoprotein oxidation plays an important part in atherogenesis. Autoantibodies to oxidation-specific epitopes of LDL occur in plasma and atherosclerotic lesions of humans and animals. The potential role of these autoantibodies in atherogenesis still remains unsolved. We studied the relationship between different isotypes of autoantibodies to copper-oxidized LDL and malondialdehyde-modified LDL (MDA-LDL) and carotid artery intima-media thickness (IMT) in a population-based cohort of 1022 middle-aged men and women. In addition, we studied the relation of C-reactive protein (CRP) to IMT.
Methods and Results— The levels of IgM, IgG, and IgG2 autoantibodies binding to MDA-LDL and copper-oxidized LDL were determined in plasma samples by chemiluminescence-based ELISA. IMT and the number of plaques were measured ultrasonographically. The subjects were divided into tertiles for antibody titers. We found an inverse association between IMT and IgM autoantibody titers to MDA-LDL that remained statistically significant after adjusting for age, gender, LDL cholesterol, systolic blood pressure, CRP, and smoking. CRP was not independently associated with IMT.
Conclusions— These results show that IgM autoantibodies to MDA-LDL have an inverse association with carotid atherosclerosis. The possible implications of this finding are discussed.
Key Words: antibodies • lipoproteins • atherosclerosis
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