Circulation. 2003;107:690-695
Published online before print January 20, 2003, doi: 10.1161/01.CIR.0000049742.68848.99
Published online before print January 20, 2003, doi: 10.1161/01.CIR.0000049742.68848.99
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(Circulation. 2003;107:690.)
© 2003 American Heart Association, Inc.
Clinical Investigation and Reports |
Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes
From the TIMI Study Group (J.A.d.L., D.A.M., M.S.S., S.A.M., C.M.G., E.M.A., C.H.M., C.P.C., E.B.); Donald W. Reynolds Cardiovascular Clinical Research Center, the University of Texas, Southwestern Medical School, Dallas, Tex (J.A.d.L.); the Cardiovascular Division, Brigham and Women’s Hospital, Boston, Mass (D.A.M., M.S.S., E.M.A., C.P.C., E.B.); and Harvard Clinical Research Institute, Boston Mass (S.A.M., C.M.G.).
Correspondence to James A. de Lemos, MD, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Room CS 7.102, Dallas, TX 75390-9047. E-mail james.delemos{at}utsouthwestern.edu
Background— Monocyte chemoattractant protein-1 (MCP-1) is a chemokine responsible for the recruitment of monocytes to sites of inflammation. MCP-1 appears to play a critical role at multiple stages in atherosclerosis, including the initiation of the fatty streak, promotion of plaque instability, and remodeling after myocardial infarction.
Methods and Results— MCP-1 was measured from frozen plasma specimens in 279 healthy volunteers and 2270 patients with acute coronary syndromes enrolled in the Oral Glycoprotein IIb/IIIa Inhibition with Orbofiban in Patients with Unstable Coronary Syndromes (OPUS-TIMI) 16 trial. Median [25th, 75th percentiles] MCP-1 levels were 157 [124, 196] pg/mL in healthy volunteers and 178 [128, 238] pg/mL in the OPUS-TIMI 16 population (P<0.001). In OPUS-TIMI 16, baseline MCP-1 levels were associated with older age, female sex, hypertension, diabetes, prior coronary disease, and renal insufficiency (P<0.01 for each) but not with smoking status, body mass index, ejection fraction, troponin I or C-reactive protein. After adjustment for differences in baseline characteristics, ECG changes, troponin I, and C-reactive protein, an MCP-1 level >75th percentile (corresponding to the 90th percentile in the healthy volunteers) was associated with an increased risk of death or myocardial infarction through 10 months of follow-up (adjusted hazard ratio, 1.53; 95% CI, 1.09 to 2.14; P=0.01).
Conclusions— In a large cohort of patients with acute coronary syndromes, an elevated baseline level of MCP-1 was associated both with traditional risk factors for atherosclerosis as well as an increased risk for death or myocardial infarction, independent of baseline variables. Because it appears to play a crucial role at multiple stages of atherosclerosis, MCP-1 is attractive as a surrogate biomarker and merits further study as a potential therapeutic target.
Key Words: infarction • ischemia • leukocytes • inflammation
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|
|
|
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|
|
|
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|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 M Nylaende, A Kroese, E Stranden, B Morken, G Sandbaek, A. Lindahl, H Arnesen, and I Seljeflot Markers of vascular inflammation are associated with the extent of atherosclerosis assessed as angiographic score and treadmill walking distances in patients with peripheral arterial occlusive disease Vascular Medicine, February 1, 2006; 11(1): 21 - 28. [Abstract] [PDF]
|
|
|
|
|
|
D. Rothenbacher, S. Muller-Scholze, C. Herder, W. Koenig, and H. Kolb Differential Expression of Chemokines, Risk of Stable Coronary Heart Disease, and Correlation with Established Cardiovascular Risk Markers Arterioscler Thromb Vasc Biol, January 1, 2006; 26(1): 194 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-S. Zhou, I. H. Schulman, P. J. Pagano, E. A. Jaimes, and L. Raij Reduced NAD(P)H Oxidase in Low Renin Hypertension: Link Among Angiotensin II, Atherogenesis, and Blood Pressure Hypertension, January 1, 2006; 47(1): 81 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
W. S. Speidl, M. Exner, J. Amighi, S. P. Kastl, G. Zorn, G. Maurer, O. Wagner, K. Huber, E. Minar, J. Wojta, et al. Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis Eur. Heart J., November 1, 2005; 26(21): 2294 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Mitchell, M. D. Brown, I. B.A. Menown, and J. A. Kline Novel Protein Markers of Acute Coronary Syndrome Complications in Low-Risk Outpatients: A Systematic Review of Potential Use in the Emergency Department Clin. Chem., November 1, 2005; 51(11): 2005 - 2012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 L. Anderson Candidate-based proteomics in the search for biomarkers of cardiovascular disease J. Physiol., February 15, 2005; 563(1): 23 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P Marso, J. W Murphy, J. A House, D. M Safley, and W. S Harris Metabolic syndrome-mediated inflammation following elective percutaneous coronary intervention Diabetes and Vascular Disease Research, February 1, 2005; 2(1): 31 - 36. [Abstract] [PDF]
|
|
|
|
|
|
R. Deo, A. Khera, D. K. McGuire, S. A. Murphy, J. de P. Meo Neto, D. A. Morrow, and J. A. de Lemos Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis J. Am. Coll. Cardiol., November 2, 2004; 44(9): 1812 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
I. F. Charo and M. B. Taubman Chemokines in the Pathogenesis of Vascular Disease Circ. Res., October 29, 2004; 95(9): 858 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
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|
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|
|
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|
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|
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|
|
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|
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|
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|
|