Circulation. 2003;107:346-354
doi: 10.1161/01.CIR.0000048893.62841.F7
doi: 10.1161/01.CIR.0000048893.62841.F7
(Circulation. 2003;107:346.)
© 2003 American Heart Association, Inc.
Special Review: Clinical Cardiology: New Frontiers |
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
Part II: The Aging Heart in Health: Links to Heart Disease
From the Gerontology Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Md; and the Framingham Heart Study, National Heart, Lung and Blood Institute, National Institutes of Health, Framingham, Mass.
Correspondence to Edward G. Lakatta, MD, National Institute on Aging, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, 5600 Nathan Shock Dr, Baltimore, MD 21224-6825. E-mail lakattae@grc.nia.nih.gov
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
A Trilogy of Heart Disease Manifestations Emerges With Advancing Age
The preceding article in this series1 reviewed evidence as to why age-associated changes in the central arterial system are risky with respect to vascular disease. In a similar vane, the focus of this article is on the potential link between age-associated changes in the heart and clinical cardiac disease outcomes.
Left ventricular hypertrophy, heart failure, and atrial fibrillation increase dramatically with age (Figure 1). The prevalence of left ventricular hypertrophy (LVH) also increases with rising blood pressure and body mass index, a measure of obesity.2–4 Whether identified by electrocardiography or echocardiography, left ventricular hypertrophy has been shown to be associated with increased risk for coronary heart disease, sudden death, stroke, and overall cardiovascular disease.4,5
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