Published online before print December 30, 2002, doi: 10.1161/01.CIR.0000044941.13346.74
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(Circulation. 2003;107:285.)
© 2003 American Heart Association, Inc.
Clinical Investigation and Reports |
Effect of Adrenergic Stimulation on Action Potential Duration Restitution in Humans
From the Department of Cardiology (P.T., P.S.), University College London Hospitals; Centre for Nonlinear Dynamics and its Applications (Z.C.), University College London; School of Biomedical Sciences (M.R.B.), University of Leeds; and Department of Cardiology (R.S., D.E., J.S.G.), Guys and St Thomas’s Hospitals, London, UK. Dr Chalabi is now at the Department of Public Health and Policy, London School of Hygiene and Tropical Medicine.
Correspondence to Dr Peter Taggart, The Hatter Institute, Department of Cardiology, University College Hospital, Grafton Way, London, WC1E 6DB. E-mail peter.taggart{at}uclh.org
Background— Enhanced sympathetic activity facilitates complex ventricular arrhythmias and fibrillation. The restitution properties of action potential duration (APD) are important determinants of electrical stability in the myocardium. Steepening of the slope of APD restitution has been shown to promote wave break and ventricular fibrillation. The effect of adrenergic stimulation on APD restitution in humans is unknown.
Methods and Results— Monophasic action potentials were recorded from the right ventricular septum in 18 patients. Standard APD restitution curves were constructed at 3 basic drive cycle lengths (CLs) of 600, 500, and 400 ms under resting conditions and during infusion of isoprenaline (15 patients) or adrenaline (3 patients). The maximum slope of the restitution curves was measured by piecewise linear regression segments of sequential 40-ms ranges of diastolic intervals in steps of 10 ms. Under control conditions, the maximum slope was steeper at longer basic CLs; eg, mean values for the maximum slope were 1.053±0.092 at CL 600 ms and 0.711±0.049 at CL 400 ms (±SEM). Isoprenaline increased the steepness of the maximum slope of APD restitution, eg, from a maximum slope of 0.923±0.058 to a maximum slope of 1.202±0.121 at CL 500 ms. The effect of isoprenaline was greater at the shorter basic CLs. A similar overall effect was observed with adrenaline.
Conclusions— The adrenergic agonists isoprenaline and adrenaline increased the steepness of the slope of the APD restitution curve in humans over a wide range of diastolic intervals. These results may relate to the known effects of adrenergic stimulation in facilitating ventricular fibrillation.
Key Words: action potentials • arrhythmia • catecholamines • electrophysiology
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