Circulation. 2003;107:2290-2293
Published online before print May 5, 2003, doi: 10.1161/01.CIR.0000070931.62772.4E
Published online before print May 5, 2003, doi: 10.1161/01.CIR.0000070931.62772.4E
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(Circulation. 2003;107:2290.)
© 2003 American Heart Association, Inc.
Brief Rapid Communications |
In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction
From Johns Hopkins University, School of Medicine, Departments of Radiology (D.L.K., E.A., J.W.M.B.) and Medicine, Division of Cardiology (A.W.H., L.C.A., J.M.H.), Baltimore, Md; Osiris Therapeutics, Inc (B.J.M., M.F.P.), Baltimore, Md; and Department of Electrical and Electronics Engineering, Bilkent University, Ankara, Turkey (E.A.).
Correspondence to Dara L. Kraitchman, Johns Hopkins University, School of Medicine, Dept of Radiology, 601 N Caroline St, Suite 4231, Baltimore, MD 21287-0845 (e-mail dara{at}mri.jhu.edu), and to Joshua M. Hare, MD, Johns Hopkins Hospital, Division of Cardiology, 600 North Wolfe St/Carnegie 568, Baltimore, MD 21287 (e-mail jhare@mail.jhmi.edu).
Background— We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model.
Methods and Results— Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16x107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals.
Conclusion— MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
Key Words: magnetic resonance imaging • myocardial infarction • cells • contrast media
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