Circulation. 2003;107:38-42
Published online before print December 16, 2002, doi: 10.1161/01.CIR.0000047700.58683.A1
Published online before print December 16, 2002, doi: 10.1161/01.CIR.0000047700.58683.A1
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(Circulation. 2003;107:38.)
© 2003 American Heart Association, Inc.
Clinical Investigation and Reports |
TAXUS I
Six- and Twelve-Month Results From a Randomized, Double-Blind Trial on a Slow-Release Paclitaxel-Eluting Stent for De Novo Coronary Lesions
From the Heart Center Siegburg (E.G., R.M., L.B., U.G.), Siegburg, Germany; Klinik Dr. Mueller (S.S.), Muenchen, Germany; Krankenhaus der Barmherzigen Brüder (K.E.H.), Trier, Germany; and Boston Scientific Corp (M.E.R.), Natick, Mass.
Correspondence to Eberhard Grube, MD, FACC, FACA, Department of Cardiology/Angiology, Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany. E-mail GrubeE{at}aol.com
Background— The TAXUS NIRx stent (Boston Scientific Corp) provides local delivery of paclitaxel via a slow-release polymer coating. The TAXUS I trial was the first in-human experience evaluating safety and feasibility of the TAXUS NIRx stent system compared with bare NIR stents (control) (Boston Scientific Corp) for treatment of coronary lesions.
Methods and Results— The TAXUS I trial was a prospective, double-blind, three-center study randomizing 61 patients with de novo or restenotic lesions (
12 mm) to receive a TAXUS (n=31) versus control (n=30) stent (diameter 3.0 or 3.5 mm). Demographics, lesion characteristics, clinical outcomes were comparable between the groups. The 30-day major adverse cardiac event (MACE) rate was 0% in both groups (P=NS). No stent thromboses were reported at 1, 6, 9, or 12 months. At 12 months, the MACE rate was 3% (1 event) in the TAXUS group and 10% (4 events in 3 patients) in the control group (P=NS). Six-month angiographic restenosis rates were 0% for TAXUS versus 10% for control (P=NS) patients. There were significant improvements in minimal lumen diameter (2.60±0.49 versus 2.19±0.65 mm), diameter stenosis (13.56±11.77 versus 27.23±16.69), and late lumen loss (0.36±0.48 versus 0.71±0.48 mm) in the TAXUS group (all P<0.01). No evidence of edge restenosis was seen in either group. Intravascular ultrasound analysis showed significant improvements in normalized neointimal hyperplasia in the TAXUS (14.8 mm3) group compared with the control group (21.6 mm3) (P<0.05).
Conclusions— In this feasibility trial, the TAXUS slow-release stent was well tolerated and showed promise for treatment of coronary lesions, with significant reductions in angiographic and intravascular ultrasound measures of restenosis.
Key Words: stents • drugs • restenosis • coronary disease • revascularization
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