Circulation. 2002;106:653-658
Published online before print July 22, 2002, doi: 10.1161/01.CIR.0000025404.78001.D8
Published online before print July 22, 2002, doi: 10.1161/01.CIR.0000025404.78001.D8
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;106:653.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Prognostic Value of Coronary Vascular Endothelial Dysfunction
From the Cardiology Branch (J.P.J.H., W.H.S., G.Z., R.M., A.P., K.R.A.N., A.A.Q.), Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Correspondence to Arshed A. Quyyumi, MD, Professor of Medicine (Cardiology), Emory University Hospital, Suite F606, 1364 Clifton Rd NE, Atlanta, GA 30322. E-mail aquyyum{at}emory.edu
Background— Whether patients at increased risk can be identified from a relatively low-risk population by coronary vascular function testing remains unknown. We investigated the relationship between coronary endothelial function and the occurrence of acute unpredictable cardiovascular events (cardiovascular death, myocardial infarction, stroke, and unstable angina) in patients with and without coronary atherosclerosis (CAD).
Methods and Results— We measured the change in coronary vascular resistance (
CVR) and epicardial diameter with intracoronary acetylcholine (ACh, 15 µg/min) to test endothelium-dependent function and sodium nitroprusside (20 µg/min) and adenosine (2.2 mg/min) to test endothelium-independent vascular function in 308 patients undergoing cardiac catheterization (132 with and 176 without CAD). Patients underwent clinical follow-up for a mean of 46±3 months. Acute vascular events occurred in 35 patients. After multivariate analysis that included CAD and conventional risk factors for atherosclerosis, CVR with ACh (P=0.02) and epicardial constriction with ACh (P=0.003), together with increasing age, CAD, and body mass index, were independent predictors of adverse events. Thus, patients in the tertile with the best microvascular responses with ACh and those with epicardial dilation with ACh had improved survival by Kaplan-Meier analyses in the total population, as did those in the subset without CAD. Similar improvement in survival was also observed when all adverse events, including revascularization, were considered. Endothelium-independent responses were not predictive of outcome.
Conclusions— Epicardial and microvascular coronary endothelial dysfunction independently predict acute cardiovascular events in patients with and without CAD, providing both functional and prognostic information that complements angiographic and risk factor assessment.
Key Words: atherosclerosis • coronary disease • endothelium • prognosis • infarction
This article has been cited by other articles:
 |
|
 |
|
  R. Rubinshtein, E. H. Yang, C. S. Rihal, A. Prasad, R. J. Lennon, P. J. Best, L. O. Lerman, and A. Lerman Coronary microcirculatory vasodilator function in relation to risk factors among patients without obstructive coronary disease and low to intermediate Framingham score Eur. Heart J., November 5, 2009; (2009) ehp459v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Schneider, M. Ritt, U. Raff, C. Ott, and R. E. Schmieder Gender is related to alterations of renal endothelial function in type 2 diabetes Nephrol. Dial. Transplant., November 1, 2009; 24(11): 3354 - 3359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Maclay, D. A. McAllister, N. L. Mills, F. P. Paterson, C. A. Ludlam, E. M. Drost, D. E. Newby, and W. MacNee Vascular Dysfunction in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., September 15, 2009; 180(6): 513 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. O. Cannon III Microvascular angina and the continuing dilemma of chest pain with normal coronary angiograms. J. Am. Coll. Cardiol., September 1, 2009; 54(10): 877 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Dohadwala and J. A. Vita Grapes and Cardiovascular Disease J. Nutr., September 1, 2009; 139(9): 1788S - 1793S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M Freeman and J. P J Halcox Vascular impact of progenitor cell mobilisation for cardiac repair post-myocardial infarction Heart, August 15, 2009; 95(16): 1301 - 1302. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Klosinska, T. Rudzinski, P. Grzelak, L. Stefanczyk, J. Drozdz, and M. Krzeminska-Pakula Endothelium-dependent and -independent vasodilation is more attenuated in ischaemic than in non-ischaemic heart failure Eur J Heart Fail, August 1, 2009; 11(8): 765 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Tardif Angiotensin-converting enzyme inhibitors and atherosclerotic plaque: a key role in the cardiovascular protection of patients with coronary artery disease Eur. Heart J. Suppl., August 1, 2009; 11(suppl_E): E9 - E16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lavi, A. Karasik, N. Koren-Morag, H. Kanety, M. S. Feinberg, and M. Shechter The acute effect of various glycemic index dietary carbohydrates on endothelial function in nondiabetic overweight and obese subjects. J. Am. Coll. Cardiol., June 16, 2009; 53(24): 2283 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Seddon, N. Melikian, R. Dworakowski, H. Shabeeh, B. Jiang, J. Byrne, B. Casadei, P. Chowienczyk, and A. M. Shah Effects of Neuronal Nitric Oxide Synthase on Human Coronary Artery Diameter and Blood Flow In Vivo Circulation, May 26, 2009; 119(20): 2656 - 2662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gulati, R. M. Cooper-DeHoff, C. McClure, B. D. Johnson, L. J. Shaw, E. M. Handberg, I. Zineh, S. F. Kelsey, M. F. Arnsdorf, H. R. Black, et al. Adverse Cardiovascular Outcomes in Women With Nonobstructive Coronary Artery Disease: A Report From the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project Arch Intern Med, May 11, 2009; 169(9): 843 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, D. A. Ingram, M. P. Murphy, M. R. Saadatzadeh, L. E. Mead, D. N. Prater, and J. Rehman Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1675 - H1682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Stokes, T. R. Dugas, Y. Tang, H. Garg, E. Guidry, and N. S. Bryan Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1281 - H1288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Phan, C. Shufelt, and C. N. B. Merz Persistent Chest Pain and No Obstructive Coronary Artery Disease JAMA, April 8, 2009; 301(14): 1468 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Gates, W. D. Strain, and A. C. Shore Human endothelial function and microvascular ageing Exp Physiol, March 1, 2009; 94(3): 311 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Haram, O. J. Kemi, S. J. Lee, M. O. Bendheim, Q. Y. Al-Share, H. L. Waldum, L. J. Gilligan, L. G. Koch, S. L. Britton, S. M. Najjar, et al. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity Cardiovasc Res, March 1, 2009; 81(4): 723 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Steffel and T. F. Luscher Predicting the Development of Atherosclerosis Circulation, February 24, 2009; 119(7): 919 - 921. [Full Text] [PDF]
|
|
|
|
|
|
J. P.J. Halcox, A. E. Donald, E. Ellins, D. R. Witte, M. J. Shipley, E. J. Brunner, M. G. Marmot, and J. E. Deanfield Endothelial Function Predicts Progression of Carotid Intima-Media Thickness Circulation, February 24, 2009; 119(7): 1005 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Schwartz and O. Wexler Early identification and monitoring progression of Chagas' cardiomyopathy with SPECT myocardial perfusion imaging. J. Am. Coll. Cardiol. Img., February 1, 2009; 2(2): 173 - 175. [Full Text] [PDF]
|
|
|
|
|
|
P. Ochodnicky, R. H. Henning, H. Buikema, A. C. A. Kluppel, M. van Wattum, D. de Zeeuw, and R. P. E. van Dokkum Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage Nephrol. Dial. Transplant., February 1, 2009; 24(2): 413 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Billecke, L. G. D'Alecy, R. Platel, S. E. Whitesall, K. A. Jamerson, R. L. Perlman, and C. A. Gadegbeku Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease Nephrol. Dial. Transplant., February 1, 2009; 24(2): 489 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Tyldum, I. E. Schjerve, A. E. Tjonna, I. Kirkeby-Garstad, T. O. Stolen, R. S. Richardson, and U. Wisloff Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise. J. Am. Coll. Cardiol., January 13, 2009; 53(2): 200 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Volzke, D. M. Robinson, T. Spielhagen, M. Nauck, A. Obst, R. Ewert, B. Wolff, H. Wallaschofski, S. B. Felix, and M. Dorr Are serum thyrotropin levels within the reference range associated with endothelial function? Eur. Heart J., January 2, 2009; 30(2): 217 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Yilmaz, H Mahrholdt, A Athanasiadis, H Vogelsberg, G Meinhardt, M Voehringer, E-M Kispert, C Deluigi, H Baccouche, E Spodarev, et al. Coronary vasospasm as the underlying cause for chest pain in patients with PVB19 myocarditis Heart, November 1, 2008; 94(11): 1456 - 1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Pries, H. Habazettl, G. Ambrosio, P. R. Hansen, J. C. Kaski, V. Schachinger, H. Tillmanns, G. Vassalli, I. Tritto, M. Weis, et al. A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings Cardiovasc Res, November 1, 2008; 80(2): 165 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Apovian, S. Bigornia, M. Mott, M. R. Meyers, J. Ulloor, M. Gagua, M. McDonnell, D. Hess, L. Joseph, and N. Gokce Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects Arterioscler Thromb Vasc Biol, September 1, 2008; 28(9): 1654 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Tjonna, S. J. Lee, O. Rognmo, T. O. Stolen, A. Bye, P. M. Haram, J. P. Loennechen, Q. Y. Al-Share, E. Skogvoll, S. A. Slordahl, et al. Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome: A Pilot Study Circulation, July 22, 2008; 118(4): 346 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ashfaq, J. L. Abramson, D. P. Jones, S. D. Rhodes, W. S. Weintraub, W. C. Hooper, V. Vaccarino, R. W. Alexander, D. G. Harrison, and A. A. Quyyumi Endothelial Function and Aminothiol Biomarkers of Oxidative Stress in Healthy Adults Hypertension, July 1, 2008; 52(1): 80 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Seddon, P. J. Chowienczyk, S. E. Brett, B. Casadei, and A. M. Shah Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo Circulation, April 15, 2008; 117(15): 1991 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Stangl, V. Witzel, G. Baumann, and K. Stangl Current diagnostic concepts to detect coronary artery disease in women Eur. Heart J., March 2, 2008; 29(6): 707 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Terashima, P. K. Nguyen, G. D. Rubin, C. Iribarren, B. K. Courtney, A. S. Go, S. P. Fortmann, and M. V. McConnell Impaired coronary vasodilation by magnetic resonance angiography is associated with advanced coronary artery calcification. J. Am. Coll. Cardiol. Img., March 1, 2008; 1(2): 167 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Brauner, L. Forchhammer, P. Moller, L. Barregard, L. Gunnarsen, A. Afshari, P. Wahlin, M. Glasius, L. O. Dragsted, S. Basu, et al. Indoor Particles Affect Vascular Function in the Aged: An Air Filtration-based Intervention Study Am. J. Respir. Crit. Care Med., February 15, 2008; 177(4): 419 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Worthley, R. S. Kanani, Y.-H. Sun, Y. Sun, D. M. Goodhart, M. J. Curtis, and T. J. Anderson Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries Cardiovasc Res, December 1, 2007; 76(3): 539 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Briet, C. Collin, S. Laurent, A. Tan, M. Azizi, M. Agharazii, X. Jeunemaitre, F. Alhenc-Gelas, and P. Boutouyrie Endothelial Function and Chronic Exposure to Air Pollution in Normal Male Subjects Hypertension, November 1, 2007; 50(5): 970 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Naya, T. Tsukamoto, K. Morita, C. Katoh, T. Furumoto, S. Fujii, N. Tamaki, and H. Tsutsui Olmesartan, But Not Amlodipine, Improves Endothelium-Dependent Coronary Dilation in Hypertensive Patients J. Am. Coll. Cardiol., September 18, 2007; 50(12): 1144 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. de Bree, L. A van Mierlo, and R. Draijer Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials Am. J. Clinical Nutrition, September 1, 2007; 86(3): 610 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tornqvist, N. L. Mills, M. Gonzalez, M. R. Miller, S. D. Robinson, I. L. Megson, W. MacNee, K. Donaldson, S. Soderberg, D. E. Newby, et al. Persistent Endothelial Dysfunction in Humans after Diesel Exhaust Inhalation Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 395 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Shenouda and J. A. Vita Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function J. Am. Coll. Nutr., August 1, 2007; 26(4): 366S - 372S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. V. Joffe, R. Y. Kwong, M. D. Gerhard-Herman, C. Rice, K. Feldman, and G. K. Adler Beneficial Effects of Eplerenone Versus Hydrochlorothiazide on Coronary Circulatory Function in Patients with Diabetes Mellitus J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2552 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Saam, T. S. Hatsukami, N. Takaya, B. Chu, H. Underhill, W. S. Kerwin, J. Cai, M. S. Ferguson, and C. Yuan The Vulnerable, or High-Risk, Atherosclerotic Plaque: Noninvasive MR Imaging for Characterization and Assessment Radiology, July 1, 2007; 244(1): 64 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Robinson, C. A. Ludlam, N. A. Boon, and D. E. Newby Endothelial Fibrinolytic Capacity Predicts Future Adverse Cardiovascular Events in Patients With Coronary Heart Disease Arterioscler Thromb Vasc Biol, July 1, 2007; 27(7): 1651 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Wisloff, A. Stoylen, J. P. Loennechen, M. Bruvold, O. Rognmo, P. M. Haram, A. E. Tjonna, J. Helgerud, S. A. Slordahl, S. J. Lee, et al. Superior Cardiovascular Effect of Aerobic Interval Training Versus Moderate Continuous Training in Heart Failure Patients: A Randomized Study Circulation, June 19, 2007; 115(24): 3086 - 3094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Authors/Task Force Members:, G. Mancia, G. De Backer, A. Dominiczak, R. Cifkova, R. Fagard, G. Germano, G. Grassi, A. M. Heagerty, S. E. Kjeldsen, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) Eur. Heart J., June 11, 2007; (2007) ehm236v1. [Full Text] [PDF]
|
|
|
|
 |
|
 S. J Hamilton, G. T Chew, and G. F Watts Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus Diabetes and Vascular Disease Research, June 1, 2007; 4(2): 89 - 102. [Abstract] [PDF]
|
|
|
|
|
|
R. M Cubbon, A. Rajwani, and S. B Wheatcroft The impact of insulin resistance on endothelial function, progenitor cells and repair Diabetes and Vascular Disease Research, June 1, 2007; 4(2): 103 - 111. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Leeson Pediatric Prevention of Atherosclerosis: Targeting Early Variation in Vascular Biology Pediatrics, June 1, 2007; 119(6): 1204 - 1206. [Full Text] [PDF]
|
|
|
|
|
|
U. Landmesser, S. Spiekermann, C. Preuss, S. Sorrentino, D. Fischer, C. Manes, M. Mueller, and H. Drexler Angiotensin II Induces Endothelial Xanthine Oxidase Activation: Role for Endothelial Dysfunction in Patients With Coronary Disease Arterioscler Thromb Vasc Biol, April 1, 2007; 27(4): 943 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Melikian, S. B. Wheatcroft, O. S. Ogah, C. Murphy, P. J. Chowienczyk, A. S. Wierzbicki, T. A.B. Sanders, B. Jiang, E. R. Duncan, A. M. Shah, et al. Asymmetric Dimethylarginine and Reduced Nitric Oxide Bioavailability in Young Black African Men Hypertension, April 1, 2007; 49(4): 873 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barac, U. Campia, and J. A. Panza Methods for Evaluating Endothelial Function in Humans Hypertension, April 1, 2007; 49(4): 748 - 760. [Full Text] [PDF]
|
|
|
|
|
|
J. E. Deanfield, J. P. Halcox, and T. J. Rabelink Endothelial Function and Dysfunction: Testing and Clinical Relevance Circulation, March 13, 2007; 115(10): 1285 - 1295. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lee, C. Shirodaria, C. E Jackson, M. D Robson, C. Antoniades, J. M Francis, F. Wiesmann, K. M Channon, S. Neubauer, and R. P Choudhury Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus Diabetes and Vascular Disease Research, March 1, 2007; 4(1): 44 - 48. [Abstract] [PDF]
|
|
|
|
 |
|
 M. S. Tonetti, F. D'Aiuto, L. Nibali, A. Donald, C. Storry, M. Parkar, J. Suvan, A. D. Hingorani, P. Vallance, and J. Deanfield Treatment of Periodontitis and Endothelial Function N. Engl. J. Med., March 1, 2007; 356(9): 911 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Krotz, M. Keller, S. Derflinger, H. Schmid, T. Gloe, F. Bassermann, J. Duyster, C. D. Cohen, C. Schuhmann, V. Klauss, et al. Mycophenolate Acid Inhibits Endothelial NAD(P)H Oxidase Activity and Superoxide Formation by a Rac1-Dependent Mechanism Hypertension, January 1, 2007; 49(1): 201 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Morita, T. Tsukamoto, M. Naya, K. Noriyasu, M. Inubushi, T. Shiga, C. Katoh, Y. Kuge, H. Tsutsui, and N. Tamaki Smoking Cessation Normalizes Coronary Endothelial Vasomotor Response Assessed with 15O-Water and PET in Healthy Young Smokers J. Nucl. Med., December 1, 2006; 47(12): 1914 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Imanishi, K. Kobayashi, A. Kuroi, S. Mochizuki, M. Goto, K. Yoshida, and T. Akasaka Effects of Angiotensin II on NO Bioavailability Evaluated Using a Catheter-Type NO Sensor Hypertension, December 1, 2006; 48(6): 1058 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Waxman, F. Ishibashi, and J. E. Muller Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events Circulation, November 28, 2006; 114(22): 2390 - 2411. [Full Text] [PDF]
|
|
|
|
|
|
G. P. Rossi, G. Maiolino, M. Zanchetta, D. Sticchi, L. Pedon, M. Cesari, D. Montemurro, R. De Toni, S. Zavattiero, and A. C. Pessina The T-786C Endothelial Nitric Oxide Synthase Genotype Predicts Cardiovascular Mortality in High-Risk Patients J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1166 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schwartz Invited Commentary: Ripeness Is All Am. J. Epidemiol., September 1, 2006; 164(5): 434 - 436. [Full Text] [PDF]
|
|
|
|
|
|
S. E. Petersen, F. Wiesmann, L. E. Hudsmith, M. D. Robson, J. M. Francis, J. B. Selvanayagam, S. Neubauer, and K. M. Channon Functional and Structural Vascular Remodeling in Elite Rowers Assessed by Cardiovascular Magnetic Resonance J. Am. Coll. Cardiol., August 15, 2006; 48(4): 790 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J Roman, T. Z Naqvi, J. M Gardin, M. Gerhard-Herman, M. Jaff, and E. Mohler American Society of Echocardiography Report: Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society for Vascular Medicine and Biology Vascular Medicine, August 1, 2006; 11(3): 201 - 211. [PDF]
|
|
|
|
|
|
I. J. Goldberg and H. M. Dansky Diabetic Vascular Disease: An Experimental Objective Arterioscler Thromb Vasc Biol, August 1, 2006; 26(8): 1693 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bugiardini, O. Manfrini, and G. M. De Ferrari Unanswered questions for management of acute coronary syndrome: risk stratification of patients with minimal disease or normal findings on coronary angiography. Arch Intern Med, July 10, 2006; 166(13): 1391 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Brown, Y. Chu, D. D. Lund, D. D. Heistad, and F. M. Faraci Gene transfer of extracellular superoxide dismutase protects against vascular dysfunction with aging Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2600 - H2605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Vasan Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations Circulation, May 16, 2006; 113(19): 2335 - 2362. [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Lee, K. E. North, M. S. Bray, M. Fornage, J. M. Seubert, J. W. Newman, B. D. Hammock, D. J. Couper, G. Heiss, and D. C. Zeldin Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study Hum. Mol. Genet., May 15, 2006; 15(10): 1640 - 1649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yang and X.-F. Ming Recent advances in understanding endothelial dysfunction in atherosclerosis. Clin. Med. Res., March 1, 2006; 4(1): 53 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Campia, L. A. Matuskey, and J. A. Panza Peroxisome Proliferator-Activated Receptor-{gamma} Activation With Pioglitazone Improves Endothelium-Dependent Dilation in Nondiabetic Patients With Major Cardiovascular Risk Factors Circulation, February 14, 2006; 113(6): 867 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. N. Bairey Merz, L. J. Shaw, S. E. Reis, V. Bittner, S. F. Kelsey, M. Olson, B. D. Johnson, C. J. Pepine, S. Mankad, B. L. Sharaf, et al. Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part II: Gender Differences in Presentation, Diagnosis, and Outcome With Regard to Gender-Based Pathophysiology of Atherosclerosis and Macrovascular and Microvascular Coronary Disease J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S21 - S29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Quyyumi Women and Ischemic Heart Disease: Pathophysiologic Implications From the Women's Ischemia Syndrome Evaluation (WISE) Study and Future Research Steps J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S66 - S71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Yang, J. P. McConnell, R. J. Lennon, G. W. Barsness, G. Pumper, S. J. Hartman, C. S. Rihal, L. O. Lerman, and A. Lerman Lipoprotein-Associated Phospholipase A2 Is an Independent Marker for Coronary Endothelial Dysfunction in Humans Arterioscler Thromb Vasc Biol, January 1, 2006; 26(1): 106 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Mills, H. Tornqvist, S. D. Robinson, M. Gonzalez, K. Darnley, W. MacNee, N. A. Boon, K. Donaldson, A. Blomberg, T. Sandstrom, et al. Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis Circulation, December 20, 2005; 112(25): 3930 - 3936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Willoughby, S. Stewart, A. S. Holmes, Y. Y. Chirkov, and J. D. Horowitz Platelet Nitric Oxide Responsiveness: A Novel Prognostic Marker in Acute Coronary Syndromes Arterioscler Thromb Vasc Biol, December 1, 2005; 25(12): 2661 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Campen, N. S. Babu, G. A. Helms, S. Pett, J. Wernly, R. Mehran, and J. D. McDonald Nonparticulate Components of Diesel Exhaust Promote Constriction in Coronary Arteries from ApoE-/- Mice Toxicol. Sci., November 1, 2005; 88(1): 95 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, A. Zhang, D.E. Kohan, R.D. Nelson, F.J. Gonzales, T. Yang, C. Schmidt-Lucke, L. Rossig, S. Fichtlscherer, M. Vasa, et al. Edema and Congestive Heart Failure from Thiazolidone Insulin Sensitizers--Excess Sodium Reabsoption in the Collecting Duct: Collecting Duct-Specific Deletion of Peroxisome Proliferator-Activated Receptor {gamma} Blocks Thiazolidinedione-Induced Fluid Retention. Proc Nat Acad Sci U S A 102: 9406-9411, 2005 J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3139 - 3142. [Full Text] [PDF]
|
|
|
|
 |
|
 K. E Pyke and M. E Tschakovsky The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function J. Physiol., October 15, 2005; 568(2): 357 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Wildhirt, C. Schulze, N. Conrad, R. Bauernschmitt, R. Lange, and W. von Scheidt Persistently increased systemic, but not cardiac-specific, adhesion molecule expression and coronary endothelial dysfunction in human cardiac allografts J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 1175 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schwaiger, S. Ziegler, and S. G. Nekolla PET/CT: Challenge for Nuclear Cardiology J. Nucl. Med., October 1, 2005; 46(10): 1664 - 1678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J P J Halcox and J E Deanfield Childhood origins of endothelial dysfunction Heart, October 1, 2005; 91(10): 1272 - 1274. [Full Text] [PDF]
|
|
|
|
|
|
J A Vita Endothelial function and clinical outcome Heart, October 1, 2005; 91(10): 1278 - 1279. [Full Text] [PDF]
|
|
|
|
|
|
N. P. Johnson and K. L. Gould Clinical Evaluation of a New Concept: Resting Myocardial Perfusion Heterogeneity Quantified by Markovian Analysis of PET Identifies Coronary Microvascular Dysfunction and Early Atherosclerosis in 1,034 Subjects J. Nucl. Med., September 1, 2005; 46(9): 1427 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Oechslin, W. Kiowski, R. Schindler, A. Bernheim, B. Julius, and H. P. Brunner-La Rocca Systemic Endothelial Dysfunction in Adults With Cyanotic Congenital Heart Disease Circulation, August 23, 2005; 112(8): 1106 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Neishi, S. Mochizuki, T. Miyasaka, T. Kawamoto, T. Kume, R. Sukmawan, M. Tsukiji, Y. Ogasawara, F. Kajiya, T. Akasaka, et al. Evaluation of bioavailability of nitric oxide in coronary circulation by direct measurement of plasma nitric oxide concentration PNAS, August 9, 2005; 102(32): 11456 - 11461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-H. Huang, L.-C. Chen, H.-B. Leu, P. Y.-A. Ding, J.-W. Chen, T.-C. Wu, and S.-J. Lin Enhanced Coronary Calcification Determined by Electron Beam CT Is Strongly Related to Endothelial Dysfunction in Patients With Suspected Coronary Artery Disease Chest, August 1, 2005; 128(2): 810 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Thanyasiri, D. S. Celermajer, and M. R. Adams Endothelial dysfunction occurs in peripheral circulation patients with acute and stable coronary artery disease Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H513 - H517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wu, L. Liu, M. Meydani, and S. N. Meydani Vitamin E Increases Production of Vasodilator Prostanoids in Human Aortic Endothelial Cells through Opposing Effects on Cyclooxygenase-2 and Phospholipase A2 J. Nutr., August 1, 2005; 135(8): 1847 - 1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.A. Lteif, K. Han, and K.J. Mather Obesity, Insulin Resistance, and the Metabolic Syndrome: Determinants of Endothelial Dysfunction in Whites and Blacks Circulation, July 5, 2005; 112(1): 32 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Arenas, S. J. Armstrong, Y. Xu, and S. T. Davidge Chronic Tumor Necrosis Factor-{alpha} Inhibition Enhances NO Modulation of Vascular Function in Estrogen-Deficient Rats Hypertension, July 1, 2005; 46(1): 76 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Witte, J. Westerink, E. J. de Koning, Y. van der Graaf, D. E. Grobbee, and M. L. Bots Is the Association Between Flow-Mediated Dilation and Cardiovascular Risk Limited to Low-Risk Populations? J. Am. Coll. Cardiol., June 21, 2005; 45(12): 1987 - 1993. [Abstract] [Full Text] [PDF]
|
|