Circulation. 2002;106:599-605
Published online before print July 15, 2002, doi: 10.1161/01.CIR.0000023532.98469.48
Published online before print July 15, 2002, doi: 10.1161/01.CIR.0000023532.98469.48
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;106:599.)
© 2002 American Heart Association, Inc.
Basic Science Reports |
Macrophage Depletion by Clodronate-Containing Liposomes Reduces Neointimal Formation After Balloon Injury in Rats and Rabbits
From the Department of Cardiology, Hadassah-Hebrew University Hospital, Jerusalem, Israel (H.D.D.); the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel (I.F., J.G., R.R., I.G., E.M., G.G.); and the Department of Pharmaceutics, University of Kuopio (Finland) (J.M.).
Correspondence to Dr Haim D. Danenberg, Department of Cardiology, Hadassah University Hospital, Jerusalem 91120, Israel (e-mail danen{at}md2.huji.ac.il), or to Dr Gershon Golomb, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Box 12065, Jerusalem 91120, Israel (e-mail golomb@md.huji.ac.il).
Background— Inflammation is critical to vascular repair after mechanical injury. Excessive inflammation enhances neointimal formation and restenosis. We examined whether transient systemic inactivation of macrophages at the time of vascular intervention could attenuate the degree of expected restenosis.
Methods and Results— Liposomal clodronate (LC) inhibited the growth of cultured macrophages but had no effect on endothelial or smooth muscle cells and suppressed neointimal hyperplasia in hypercholesterolemic rabbits and rats after intravenous administration of LC, with no adverse effects. LC treatment reduced the number of blood monocytes and decreased macrophage infiltration in the injured arteries as well as smooth muscle cell proliferation, interleukin-1ß transcription, and production and matrix metalloproteinase-2 activity.
Conclusions— Macrophages play a pivotal role in vascular repair after mechanical arterial injury. Systemic inactivation and depletion of monocytes and macrophages by LC reduce neointimal hyperplasia and restenosis.
Key Words: angioplasty • balloon • restenosis • monocytes • drugs
This article has been cited by other articles:
 |
|
 |
|
  H. R. Zandbergen, U. C. Sharma, S. Gupta, J. W. H. Verjans, S. van den Borne, S. Pokharel, T. van Brakel, A. Duijvestijn, N. van Rooijen, J. G. Maessen, et al. Macrophage Depletion in Hypertensive Rats Accelerates Development of Cardiomyopathy Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2009; 14(1): 68 - 75. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Haber, H.D. Danenberg, N. Koroukhov, R. Ron-El, G. Golomb, and M. Schachter Peritoneal macrophage depletion by liposomal bisphosphonate attenuates endometriosis in the rat model Hum. Reprod., February 1, 2009; 24(2): 398 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Rodriguez-Menocal, M. St-Pierre, Y. Wei, S. Khan, D. Mateu, M. Calfa, A. A. Rahnemai-Azar, G. Striker, S. M. Pham, and R. I. Vazquez-Padron The origin of post-injury neointimal cells in the rat balloon injury model Cardiovasc Res, January 1, 2009; 81(1): 46 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kerdjoudj, N. Berthelemy, S. Rinckenbach, A. Kearney-Schwartz, K. Montagne, P. Schaaf, P. Lacolley, J.-F. Stoltz, J.-C. Voegel, and P. Menu Small Vessel Replacement by Human Umbilical Arteries With Polyelectrolyte Film-Treated Arteries: In Vivo Behavior J. Am. Coll. Cardiol., November 4, 2008; 52(19): 1589 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takahashi, E. Suzuki, R. Takeda, S. Oba, H. Nishimatsu, K. Kimura, T. Nagano, R. Nagai, and Y. Hirata Angiotensin II and tumor necrosis factor-{alpha} synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-{kappa}B, p38, and reactive oxygen species Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2879 - H2888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Bryer, G. Fantuzzi, N. Van Rooijen, and T. J. Koh Urokinase-Type Plasminogen Activator Plays Essential Roles in Macrophage Chemotaxis and Skeletal Muscle Regeneration J. Immunol., January 15, 2008; 180(2): 1179 - 1188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fallowfield, M. Mizuno, T. J. Kendall, C. M. Constandinou, R. C. Benyon, J. S. Duffield, and J. P. Iredale Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis J. Immunol., April 15, 2007; 178(8): 5288 - 5295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Stoneman, D. Braganza, N. Figg, J. Mercer, R. Lang, M. Goddard, and M. Bennett Monocyte/Macrophage Suppression in CD11b Diphtheria Toxin Receptor Transgenic Mice Differentially Affects Atherogenesis and Established Plaques Circ. Res., March 30, 2007; 100(6): 884 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. van Amerongen, M. C. Harmsen, N. van Rooijen, A. H. Petersen, and M. J.A. van Luyn Macrophage Depletion Impairs Wound Healing and Increases Left Ventricular Remodeling after Myocardial Injury in Mice Am. J. Pathol., March 1, 2007; 170(3): 818 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Frid, J. A. Brunetti, D. L. Burke, T. C. Carpenter, N. J. Davie, J. T. Reeves, M. T. Roedersheimer, N. van Rooijen, and K. R. Stenmark Hypoxia-Induced Pulmonary Vascular Remodeling Requires Recruitment of Circulating Mesenchymal Precursors of a Monocyte/Macrophage Lineage Am. J. Pathol., February 1, 2006; 168(2): 659 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Duffield, P. G. Tipping, T. Kipari, J.-F. Cailhier, S. Clay, R. Lang, J. V. Bonventre, and J. Hughes Conditional Ablation of Macrophages Halts Progression of Crescentic Glomerulonephritis Am. J. Pathol., November 1, 2005; 167(5): 1207 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Titos, J. Claria, A. Planaguma, M. Lopez-Parra, A. Gonzalez-Periz, J. Gaya, R. Miquel, V. Arroyo, and J. Rodes Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells J. Leukoc. Biol., October 1, 2005; 78(4): 871 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Bonvini, T. Hendiri, and E. Camenzind Inflammatory response post-myocardial infarction and reperfusion: a new therapeutic target? Eur. Heart J. Suppl., October 1, 2005; 7(suppl_I): I27 - I36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hamerman Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies QJM, July 1, 2005; 98(7): 467 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Day, L. Huang, H. Ye, J. Linden, and M. D. Okusa Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages Am J Physiol Renal Physiol, April 1, 2005; 288(4): F722 - F731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Takeda, E. Suzuki, H. Satonaka, S. Oba, H. Nishimatsu, M. Omata, T. Fujita, R. Nagai, and Y. Hirata Blockade of Endogenous Cytokines Mitigates Neointimal Formation in Obese Zucker Rats Circulation, March 22, 2005; 111(11): 1398 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Suzuki, H. Satonaka, H. Nishimatsu, S. Oba, R. Takeda, M. Omata, T. Fujita, R. Nagai, and Y. Hirata Myocyte Enhancer Factor 2 Mediates Vascular Inflammation via the p38-Dependent Pathway Circ. Res., July 9, 2004; 95(1): 42 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Abedin, Y. Tintut, and L. L. Demer Vascular Calcification: Mechanisms and Clinical Ramifications Arterioscler Thromb Vasc Biol, July 1, 2004; 24(7): 1161 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Zeiffer, A. Schober, M. Lietz, E. A. Liehn, W. Erl, N. Emans, Z.-q. Yan, and C. Weber Neointimal Smooth Muscle Cells Display a Proinflammatory Phenotype Resulting in Increased Leukocyte Recruitment Mediated by P-Selectin and Chemokines Circ. Res., April 2, 2004; 94(6): 776 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Satonaka, E. Suzuki, H. Nishimatsu, S. Oba, R. Takeda, A. Goto, M. Omata, T. Fujita, R. Nagai, and Y. Hirata Calcineurin Promotes the Expression of Monocyte Chemoattractant Protein-1 in Vascular Myocytes and Mediates Vascular Inflammation Circ. Res., March 19, 2004; 94(5): 693 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schober, J. Bernhagen, M. Thiele, U. Zeiffer, S. Knarren, M. Roller, R. Bucala, and C. Weber Stabilization of Atherosclerotic Plaques by Blockade of Macrophage Migration Inhibitory Factor After Vascular Injury in Apolipoprotein E-Deficient Mice Circulation, January 27, 2004; 109(3): 380 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Colombo and G. Sangiorgi The monocyte: the key in the lock to reduce stent hyperplasia? J. Am. Coll. Cardiol., January 7, 2004; 43(1): 24 - 26. [Full Text] [PDF]
|
|
|
|
|
|
H. D. Danenberg, G. Golomb, A. Groothuis, J. Gao, H. Epstein, R. V. Swaminathan, P. Seifert, and E. R. Edelman Liposomal Alendronate Inhibits Systemic Innate Immunity and Reduces In-Stent Neointimal Hyperplasia in Rabbits Circulation, December 2, 2003; 108(22): 2798 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kereiakes Adjunctive Pharmacotherapy before Percutaneous Coronary Intervention in Non-ST-Elevation Acute Coronary Syndromes: The Role of Modulating Inflammation Circulation, October 21, 2003; 108(90161): III-22 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Pipp, M. Heil, K. Issbrucker, T. Ziegelhoeffer, S. Martin, J. van den Heuvel, H. Weich, B. Fernandez, G. Golomb, P. Carmeliet, et al. VEGFR-1-Selective VEGF Homologue PlGF Is Arteriogenic: Evidence for a Monocyte-Mediated Mechanism Circ. Res., March 7, 2003; 92(4): 378 - 385. [Abstract] [Full Text] [PDF]
|
|