This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rosen, M. R. Search for Related Content PubMed PubMed Citation Articles by Rosen, M. R. Related Collections Electrophysiology Arrythmias-basic studies Physiological and pathological control of gene expression Electrocardiology Arrhythmias, clinical electrophysiology, drugs

(Circulation. 2002;106:2173.)
© 2002 American Heart Association, Inc.

Special Report

The Electrocardiogram 100 Years Later

Electrical Insights Into Molecular Messages

Michael R. Rosen, MD

From the Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY.

Correspondence to Michael R. Rosen, MD, Gustavus A. Pfeiffer Professor of Pharmacology, Professor of Pediatrics, Director, Center for Molecular Therapeutics, College of Physicians and Surgeons of Columbia University, 630 West 168 St, PH7West-321, New York, NY 10032. E-mail mrr1@columbia.edu

An extract of the first 250 words of the full text is provided, because this article has no abstract.

In 1921, Willem Einthoven invited Thomas Lewis to lecture in Leiden. Lewis responded, "The Leiden visit is one to which I am looking forward with great pleasure. It will be most stimulating to come to the Mecca of electrocardiography ..."¹ It is with much the same feeling that I approach this lectureship, honoring the memory of the man who, in developing the ECG, in effect ushered in the modern era in electrophysiology. In being here, I also pay homage to the Dutch tradition of electrophysiology, which has flourished since Einthoven’s time.

In 1930, several years after Einthoven’s passing, the Russian electrophysiologist Samojloff was invited by Paul Dudley White (later the first Einthoven Lecturer) to reminisce about Einthoven’s contributions. Samojloff stated, "... Einthoven worked almost exclusively in the field of electrophysiology. This branch of physiology stood for a long time completely isolated from life, medicine, and even from the general path of development of physiological knowledge; shut off in this way, electrophysiology could not progress and it seemed that it would be difficult to alter this sad situation of the study of animal electricity. [Einthoven’s mind] ... worked like an instrument of precision. He worked only on what could be measured and his measurements reached the limit of precision possible under the circumstances."²

Einthoven’s string galvanometer was remarkable in the fidelity and accuracy of its recordings and in its utility for interpreting the rhythm and state of health of the heart. Moreover, in applying the instrument to diagnosis, Einthoven foresaw events . . . [Full Text of this Article]

This article has been cited by other articles:

				C. F. Barrett and R. W. Tsien The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels PNAS, February 12, 2008; 105(6): 2157 - 2162. [Abstract] [Full Text] [PDF]

				K. W. Patberg and M. R. Rosen On the Role of the cAMP Response Element Binding Protein in Long-Term Cardiac Memory Circ. Res., October 31, 2003; 93 (9): e87 - e87. [Full Text] [PDF]

				E. J. Folco, K. Roder, G. F. Mitchell, and G. Koren "Cardiac Memory": A Struggle Against Forgetting Circ. Res., September 5, 2003; 93(5): 384 - 386. [Full Text] [PDF]