Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
Circulation. 2002;106:2137-2142
doi: 10.1161/01.CIR.0000035280.64322.31
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ginsberg, H. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ginsberg, H. N.
Related Collections
Right arrow Lipids
Right arrow Animal models of human disease
Right arrow Pathophysiology
Right arrow Risk Factors
Right arrow Gene regulation
Right arrow Genetically altered mice
Right arrow Genetics of cardiovascular disease
Right arrow Lipid and lipoprotein metabolism

(Circulation. 2002;106:2137.)
© 2002 American Heart Association, Inc.


Mini-Review: From Bench to Bedside

New Perspectives on Atherogenesis

Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism

Henry N. Ginsberg, MD

From the Columbia University College of Physicians and Surgeons, New York, NY.

Correspondence to Henry N. Ginsberg, MD, Department of Medicine, PH 10-305, Columbia University, 630 West 168th St, New York, NY 10032. E-mail hng1@columbia.edu


Key Words: apolipoproteins • lipids • lipoproteins • atherosclerosis • hyperlipoproteinemia


An extract of the first 250 words of the full text is provided, because this article has no abstract.
 


*    Introduction
 
Atherosclerosis, along with the resultant coronary artery disease (CAD), is a leading cause of mortality in industrialized countries. Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of CAD. A dyslipidemia characterized by a combination of abnormalities in the plasma levels of triglycerides and high-density lipoprotein (HDL) cholesterol, with or without elevated LDL cholesterol levels, affects many persons with premature CAD, however. In particular, both qualitative and quantitative abnormalities in circulating triglyceride-rich lipoproteins (TRLPs) may be a key factor in the development of CAD.1

A number of advances have led to an increased appreciation of TRLP concentrations as independent predictors of risk for CAD. First, the meta-analysis by Hokanson and Austin2 demonstrated that increases in plasma triglyceride levels were associated with increased risk for CAD events, even after adjusting for numerous other predictive factors. The meta-analysis was supported by a more recent prospective study by Jeppesen et al,3 which demonstrated that triglyceride levels were independent predictors of ischemic heart disease in men. Second, a number of studies have demonstrated that TRLPs, whether assembled in and secreted from the intestine or the liver, can penetrate the artery wall and initiate or aggravate atherogenesis. Third, during the last decade, we have gained a much more detailed understanding of the metabolic relationship between high levels of TRLPs, low levels of high-density lipoprotein (HDL) cholesterol, and an abnormally small, cholesterol-depleted, dense LDL.4 This review will attempt to bring together information from recent cellular, biochemical, physiological, and molecular studies to . . . [Full Text of this Article]




This article has been cited by other articles:


Home page
J. Lipid Res.Home page
D. T. Chan, G. K. Dogra, A. B. Irish, E. M. Ooi, P. H. Barrett, D. C. Chan, and G. F. Watts
Chronic kidney disease delays VLDL-apoB-100 particle catabolism: potential role of apolipoprotein C-III
J. Lipid Res., December 1, 2009; 50(12): 2524 - 2531.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
G. Reyes-Soffer, S. Holleran, W. Karmally, C. I. Ngai, N.-T. Chen, M. Torres, R. Ramakrishnan, W. S. Blaner, L. Berglund, H. N. Ginsberg, et al.
Measures of postprandial lipoproteins are not associated with coronary artery disease in patients with type 2 diabetes mellitus
J. Lipid Res., September 1, 2009; 50(9): 1901 - 1909.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
Y. Zhao, B. Su, R. L. Jacobs, B. Kennedy, G. A. Francis, E. Waddington, J. T. Brosnan, J. E. Vance, and D. E. Vance
Lack of Phosphatidylethanolamine N-Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice
Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1349 - 1355.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
D. E. Laaksonen, L. Niskanen, K. Nyyssonen, T. A. Lakka, J. A. Laukkanen, and J. T. Salonen
Dyslipidaemia as a predictor of hypertension in middle-aged men
Eur. Heart J., October 2, 2008; 29(20): 2561 - 2568.
[Abstract] [Full Text] [PDF]


Home page
JAMAHome page
S. Bansal, J. E. Buring, N. Rifai, S. Mora, F. M. Sacks, and P. M Ridker
Fasting Compared With Nonfasting Triglycerides and Risk of Cardiovascular Events in Women
JAMA, July 18, 2007; 298(3): 309 - 316.
[Abstract] [Full Text] [PDF]


Home page
JAMAHome page
P. E. McBride
Triglycerides and Risk for Coronary Heart Disease
JAMA, July 18, 2007; 298(3): 336 - 338.
[Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
J.-Y. Guh, H.-C. Chen, J.-F. Tsai, and L.-Y. Chuang
Betel-quid use is associated with heart disease in women
Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1229 - 1235.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
K. Chu, M. Miyazaki, W. C. Man, and J. M. Ntambi
Stearoyl-Coenzyme A Desaturase 1 Deficiency Protects against Hypertriglyceridemia and Increases Plasma High-Density Lipoprotein Cholesterol Induced by Liver X Receptor Activation.
Mol. Cell. Biol., September 1, 2006; 26(18): 6786 - 6798.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
M. N. Nguyen, D. C. Chan, K. P. Dwyer, P. Bolitho, G. F. Watts, and P. H. R. Barrett
Use of Intralipid for kinetic analysis of HDL apoC-III: evidence for a homogeneous kinetic pool of apoC-III in plasma
J. Lipid Res., June 1, 2006; 47(6): 1274 - 1280.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
C.-H. Lee, K. Kang, I. R. Mehl, R. Nofsinger, W. A. Alaynick, L.-W. Chong, J. M. Rosenfeld, and R. M. Evans
Peroxisome proliferator-activated receptor {delta} promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage
PNAS, February 14, 2006; 103(7): 2434 - 2439.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
A. K. Berfield, A. Chait, J. F. Oram, R. A. Zager, A. C. Johnson, and C. K. Abrass
IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride
Am J Physiol Renal Physiol, January 1, 2006; 290(1): F138 - F147.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
T. Pischon, C. J. Girman, F. M. Sacks, N. Rifai, M. J. Stampfer, and E. B. Rimm
Non-High-Density Lipoprotein Cholesterol and Apolipoprotein B in the Prediction of Coronary Heart Disease in Men
Circulation, November 29, 2005; 112(22): 3375 - 3383.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
P. P. Toth
Adiponectin and high-density lipoprotein: a metabolic association through thick and thin
Eur. Heart J., August 2, 2005; 26(16): 1579 - 1581.
[Full Text] [PDF]


Home page
Clin. Chem.Home page
D. C. Chan, G. F. Watts, T. W.K. Ng, Y. Uchida, N. Sakai, S. Yamashita, and P. H. R. Barrett
Adiponectin and other Adipocytokines as Predictors of Markers of Triglyceride-Rich Lipoprotein Metabolism
Clin. Chem., March 1, 2005; 51(3): 578 - 585.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
W. Khovidhunkit, M.-S. Kim, R. A. Memon, J. K. Shigenaga, A. H. Moser, K. R. Feingold, and C. Grunfeld
Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host
J. Lipid Res., July 1, 2004; 45(7): 1169 - 1196.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
T. P. Beyer, R. J. Schmidt, P. Foxworthy, Y. Zhang, J. Dai, W. R. Bensch, R. F. Kauffman, H. Gao, T. P. Ryan, X.-C. Jiang, et al.
Coadministration of a Liver X Receptor Agonist and a Peroxisome Proliferator Activator Receptor-{alpha} Agonist in Mice: Effects of Nuclear Receptor Interplay on High-Density Lipoprotein and Triglyceride Metabolism in Vivo
J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 861 - 868.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
K. Shiwaku, M. Hashimoto, K. Kitajima, A. Nogi, E. Anuurad, B. Enkhmaa, J.-M. Kim, I.-S. Kim, S.-K. Lee, T. Oyunsuren, et al.
Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians
J. Lipid Res., May 1, 2004; 45(5): 914 - 922.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
C.-H. Lee, P. Olson, and R. M. Evans
Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors
Endocrinology, June 1, 2003; 144(6): 2201 - 2207.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
Y. Ando, T. Shimizugawa, S. Takeshita, M. Ono, M. Shimamura, R. Koishi, and H. Furukawa
A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice
J. Lipid Res., June 1, 2003; 44(6): 1216 - 1223.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
B. Metzler, R. Abia, M. Ahmad, F. Wernig, O. Pachinger, Y. Hu, and Q. Xu
Activation of Heat Shock Transcription Factor 1 in Atherosclerosis
Am. J. Pathol., May 1, 2003; 162(5): 1669 - 1676.
[Abstract] [Full Text] [PDF]