Published online before print December 31, 2001, doi: 10.1161/hc0602.103583
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;105:697.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Cell Membrane Trans-Fatty Acids and the Risk of Primary Cardiac Arrest
From the Cardiovascular Health Research Unit, Departments of Medicine (R.N.L., D.S.S., R.M.P., S.W., R.H.K., M.K.C., L.A.C.) and Epidemiology (D.S.S.), University of Washington, Seattle; Public Health Sciences Division (I.B.K.), Fred Hutchinson Cancer Research Center, Seattle, Wash; and the Institute for Social Research (T.E.R.), University of Michigan, Ann Arbor.
Correspondence to Rozenn N. Lemaitre, PhD, MPH, University of Washington, Cardiovascular Health Research Unit, Metropolitan Park, East Tower, Suite 1360, 1730 Minor Ave, Seattle, WA 98101. E-mail rozenl{at}u.washington.edu
Background— The relation of trans-fatty acid intake to life-threatening arrhythmias and primary cardiac arrest is unknown.
Methods and Results— We investigated the association of trans-fatty acid intake, assessed through a biomarker, with the risk of primary cardiac arrest in a population-based case-control study. Cases, aged 25 to 74 years, were out-of-hospital cardiac arrest patients attended by paramedics in Seattle, Washington from 1988 to 1999 (n=179). Controls, matched to cases by age and sex, were randomly identified from the community (n=285). Participants were free of previous clinically diagnosed heart disease. Blood was obtained at the time of cardiac arrest (cases) or at the time of an interview (controls) to assess trans-fatty acid intake. Higher total trans-fatty acids in red blood cell membranes was associated with a modest increase in the risk of primary cardiac arrest after adjustment for medical and lifestyle risk factors (odds ratio for interquintile range, 1.5; 95% CI, 1.0 to 2.1). However, trans isomers of oleic acid were not associated with risk (odds ratio for interquintile range, 0.8; 95% CI, 0.5 to 1.2), whereas higher levels of trans isomers of linoleic acid were associated with 3-fold increase in risk (odds ratio for interquintile range, 3.1; 95% CI, 1.7 to 5.4).
Conclusions— These findings suggest that dietary intake of total trans-fatty acids is associated with modest increase and trans isomers of linoleic acid with a larger increase in the risk of primary cardiac arrest. These associations need to be confirmed in future studies that distinguish between trans isomers of linoleic acid and trans isomers of oleic acid.
Key Words: heart arrest • fatty acids • epidemiology
This article has been cited by other articles:
 |
|
 |
|
  M. K. Duda, K. M. O'Shea, and W. C. Stanley {omega}-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential Cardiovasc Res, October 1, 2009; 84(1): 33 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S Harris The omega-3 index as a risk factor for coronary heart disease Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1997S - 2002S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mozaffarian Commentary: Ruminant trans fatty acids and coronary heart disease--cause for concern? Int. J. Epidemiol., February 1, 2008; 37(1): 182 - 184. [Full Text] [PDF]
|
|
|
|
|
|
Q. Sun, J. Ma, H. Campos, and F. B Hu Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease Am. J. Clinical Nutrition, October 1, 2007; 86(4): 929 - 937. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Liu, F. R. Schumacher, S. J. Plummer, E. Jorgenson, G. Casey, and J. S. Witte trans-Fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant Carcinogenesis, June 1, 2007; 28(6): 1232 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Sun, J. Ma, H. Campos, S. E. Hankinson, J. E. Manson, M. J. Stampfer, K. M. Rexrode, W. C. Willett, and F. B. Hu A Prospective Study of Trans Fatty Acids in Erythrocytes and Risk of Coronary Heart Disease Circulation, April 10, 2007; 115(14): 1858 - 1865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. P. Zaloga, K. A. Harvey, W. Stillwell, and R. Siddiqui Trans Fatty Acids and Coronary Heart Disease Nutr Clin Pract, October 1, 2006; 21(5): 505 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Lemaitre, I. B. King, D. Mozaffarian, N. Sotoodehnia, T. D. Rea, L. H. Kuller, R. P. Tracy, and D. S. Siscovick Plasma Phospholipid Trans Fatty Acids, Fatal Ischemic Heart Disease, and Sudden Cardiac Death in Older Adults: The Cardiovascular Health Study Circulation, July 18, 2006; 114(3): 209 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sotoodehnia, D. S. Siscovick, M. Vatta, B. M. Psaty, R. P. Tracy, J. A. Towbin, R. N. Lemaitre, T. D. Rea, J. P. Durda, J. M. Chang, et al. {beta}2-Adrenergic Receptor Genetic Variants and Risk of Sudden Cardiac Death Circulation, April 18, 2006; 113(15): 1842 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mozaffarian, M. B. Katan, A. Ascherio, M. J. Stampfer, and W. C. Willett Trans Fatty Acids and Cardiovascular Disease N. Engl. J. Med., April 13, 2006; 354(15): 1601 - 1613. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Monge-Rojas, H. Campos, and X. Fernandez Rojas Saturated and Cis- and Trans-Unsaturated Fatty Acids Intake in Rural and Urban Costa Rican Adolescents J. Am. Coll. Nutr., August 1, 2005; 24(4): 286 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. B. King, A. R. Kristal, S. Schaffer, M. Thornquist, and G. E. Goodman Serum Trans-Fatty Acids Are Associated with Risk of Prostate Cancer in {beta}-Carotene and Retinol Efficacy Trial Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 988 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lopez-Garcia, M. B. Schulze, J. B. Meigs, J. E. Manson, N. Rifai, M. J. Stampfer, W. C. Willett, and F. B. Hu Consumption of Trans Fatty Acids Is Related to Plasma Biomarkers of Inflammation and Endothelial Dysfunction J. Nutr., March 1, 2005; 135(3): 562 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian, E. B Rimm, I. B King, R. L Lawler, G. B McDonald, and W. C Levy trans Fatty acids and systemic inflammation in heart failure Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1521 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baylin and H. Campos Arachidonic Acid in Adipose Tissue Is Associated with Nonfatal Acute Myocardial Infarction in the Central Valley of Costa Rica J. Nutr., November 1, 2004; 134(11): 3095 - 3099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian, T. Pischon, S. E Hankinson, N. Rifai, K. Joshipura, W. C Willett, and E. B Rimm Dietary intake of trans fatty acids and systemic inflammation in women Am. J. Clinical Nutrition, April 1, 2004; 79(4): 606 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Larsen, S. Toubro, and A. Astrup Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies J. Lipid Res., December 1, 2003; 44(12): 2234 - 2241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. McAnulty Atrial fibrillation--more evidence that it's here to stay J. Am. Coll. Cardiol., July 2, 2003; 42(1): 101 - 102. [Full Text] [PDF]
|
|
|
|
|
|
A. T Erkkila, S. Lehto, K. Pyorala, and M. I. Uusitupa n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease Am. J. Clinical Nutrition, July 1, 2003; 78(1): 65 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baylin, E. K. Kabagambe, A. Ascherio, D. Spiegelman, and H. Campos High 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults J. Nutr., April 1, 2003; 133(4): 1186 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian, R. N. Lemaitre, L. H. Kuller, G. L. Burke, R. P. Tracy, and D. S. Siscovick Cardiac Benefits of Fish Consumption May Depend on the Type of Fish Meal Consumed: The Cardiovascular Health Study Circulation, March 18, 2003; 107(10): 1372 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. B. Hu and W. C. Willett Optimal Diets for Prevention of Coronary Heart Disease JAMA, November 27, 2002; 288(20): 2569 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Katz Trans-Fatty Acids and Sudden Cardiac Death Circulation, February 12, 2002; 105(6): 669 - 671. [Full Text] [PDF]
|
|