Circulation. 2002;105:2392-2397
Published online before print April 29, 2002, doi: 10.1161/01.CIR.0000016642.15031.34
Published online before print April 29, 2002, doi: 10.1161/01.CIR.0000016642.15031.34
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;105:2392.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
B-Type Natriuretic Peptide Predicts Sudden Death in Patients With Chronic Heart Failure
From the Department of Cardiology, Ludwig Boltzman Institute of Experimental Endocrinology and Ludwig Boltzman Institute of Cardiovascular Research, University of Vienna, Austria.
Correspondence to Rudolf Berger, MD, University of Vienna, Department of Cardiology, Waehringer Guertel 18-20, A-1090 Vienna, Austria. E-mail rberger{at}gmx.at
Background— Given the high incidence of sudden death in patients with chronic heart failure (CHF) and the efficacy of implantable cardioverter-defibrillators, an appropriate tool for the prediction of sudden death is desirable. B-type natriuretic peptide (BNP) has prognostic significance in CHF, and the stimuli for its production cause electrophysiological abnormalities. This study tests BNP levels as a predictor of sudden death.
Methods and Results— BNP levels, in addition to other neurohormonal, clinical, and hemodynamic variables, were obtained from 452 patients with a left ventricular ejection fraction (LVEF) 
35%. For prediction of sudden death, only survivors without heart transplantation (HTx) or a mechanical assist device and patients who died suddenly were analyzed. Up to 3 years, 293 patients survived without HTx or a mechanical assist device, 89 patients died, and 65 patients underwent HTx. Mode of death was sudden in 44 patients (49%), whereas 31 patients (35%) had pump failure and 14 patients (16%) died from other causes. Univariate risk factors of sudden death were log BNP (P=0.0006), log N-terminal atrial natriuretic peptide (P=0.003), LVEF (P=0.005), log N-terminal BNP (P=0.006), systolic blood pressure (P=0.01), big endothelin (P=0.03), and NYHA class (P=0.04). In the multivariate model, log BNP level was the only independent predictor of sudden death (P=0.0006). Using a cutoff point of log BNP <2.11 (130 pg/mL), Kaplan-Meier sudden death–free survival rates were significantly higher in patients below (99%) compared with patients above (81%) this cutoff point (P=0.0001).
Conclusion— BNP levels are a strong, independent predictor of sudden death in patients with CHF.
Key Words: heart failure • death, sudden • prognosis • natriuretic peptides
This article has been cited by other articles:
 |
|
 |
|
  E. M. Kanoupakis, E. G. Manios, and P. E. Vardas Predicting future shocks in implantable cardioverter defibrillator recipients: the role of biomarkers Europace, November 1, 2009; 11(11): 1434 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kusunose, H. Yamada, S. Nishio, N. Tomita, T. Niki, K. Yamaguchi, K. Koshiba, S. Yagi, Y. Taketani, T. Iwase, et al. Clinical Utility of Single-Beat E/e' Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation With Preserved Systolic Function J. Am. Coll. Cardiol. Img., October 1, 2009; 2(10): 1147 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Scott, J. Barry, P. R. Roberts, and J. M. Morgan Brain natriuretic peptide for the prediction of sudden cardiac death and ventricular arrhythmias: a meta-analysis Eur J Heart Fail, October 1, 2009; 11(10): 958 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Oscarsson, M. Fredrikson, M. Sorliden, S. Anskar, and C. Eintrei N-terminal fragment of pro-B-type natriuretic peptide is a predictor of cardiac events in high-risk patients undergoing acute hip fracture surgery Br. J. Anaesth., August 1, 2009; 103(2): 206 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Chugh and K. Reinier Predicting Sudden Death in the General Population: Another Step, N Terminal B-Type Natriuretic Factor Levels Circulation, June 9, 2009; 119(22): 2863 - 2864. [Full Text] [PDF]
|
|
|
|
|
|
E. C. Korngold, J. L. Januzzi Jr, M. L. Gantzer, M.V. Moorthy, N. R. Cook, and C. M. Albert Amino-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein as Predictors of Sudden Cardiac Death Among Women Circulation, June 9, 2009; 119(22): 2868 - 2876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Vazquez, A. Bayes-Genis, I. Cygankiewicz, D. Pascual-Figal, L. Grigorian-Shamagian, R. Pavon, J. R. Gonzalez-Juanatey, J. M. Cubero, L. Pastor, J. Ordonez-Llanos, et al. The MUSIC Risk score: a simple method for predicting mortality in ambulatory patients with chronic heart failure Eur. Heart J., May 1, 2009; 30(9): 1088 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Frankenstein, A L Clark, K Goode, L Ingle, A Remppis, D Schellberg, F Grabs, M Nelles, J G F Cleland, H A Katus, et al. The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age Heart, May 1, 2009; 95(10): 825 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Adlbrecht, M. Hulsmann, G. Strunk, R. Berger, D. Mortl, J. Struck, N. G. Morgenthaler, A. Bergmann, J. Jakowitsch, G. Maurer, et al. Prognostic value of plasma midregional pro-adrenomedullin and C-terminal-pro-endothelin-1 in chronic heart failure outpatients Eur J Heart Fail, April 1, 2009; 11(4): 361 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mangat, C. Carter, G. Riley, Y. Foo, and M. Burch The clinical utility of brain natriuretic peptide in paediatric left ventricular failure Eur J Heart Fail, January 1, 2009; 11(1): 48 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J P Kaski, M T Tome-Esteban, S Mead-Regan, A Pantazis, J Marek, J E Deanfield, W J McKenna, and P M Elliott B-type natriuretic peptide predicts disease severity in children with hypertrophic cardiomyopathy Heart, October 1, 2008; 94(10): 1307 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Winkler, C. Wanner, C. Drechsler, J. Lilienthal, W. Marz, V. Krane, and for the German Diabetes and Dialysis Study Investi Change in N-terminal-pro-B-type-natriuretic-peptide and the risk of sudden death, stroke, myocardial infarction, and all-cause mortality in diabetic dialysis patients Eur. Heart J., September 1, 2008; 29(17): 2092 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ichinose, H. Otani, M. Oikawa, K. Takase, H. Saito, H. Shimokawa, and S. Takahashi MRI of Cardiac Sarcoidosis: Basal and Subepicardial Localization of Myocardial Lesions and Their Effect on Left Ventricular Function Am. J. Roentgenol., September 1, 2008; 191(3): 862 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ding, W. Hua, H. Niu, K. Chen, and S. Zhang Primary prevention of sudden cardiac death using implantable cardioverter defibrillators Europace, September 1, 2008; 10(9): 1034 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Waldo, J. Beede, S. Isakson, S. Villard-Saussine, J. Fareh, P. Clopton, R. L. Fitzgerald, and A. S. Maisel Pro-B-Type Natriuretic Peptide Levels in Acute Decompensated Heart Failure J. Am. Coll. Cardiol., May 13, 2008; 51(19): 1874 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Paniagua, D. Amato, S. Mujais, E. Vonesh, A. Ramos, R. Correa-Rotter, and W. H. Horl Predictive Value of Brain Natriuretic Peptides in Patients on Peritoneal Dialysis: Results from the ADEMEX Trial Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 407 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ballo, A. Bocelli, and S. Mondillo Letter by Ballo et al Regarding Article, "Serial Biomarker Measurements in Ambulatory Patients With Chronic Heart Failure: The Importance of Change Over Time" Circulation, January 29, 2008; 117(4): e23 - e23. [Full Text] [PDF]
|
|
|
|
|
|
L. B. Daniels and A. S. Maisel Natriuretic Peptides J. Am. Coll. Cardiol., December 18, 2007; 50(25): 2357 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Myles, C. E. Jackson, I. Tsorlalis, M. C. Petrie, J. J. V. McMurray, and S. M. Cobbe Is Microvolt T-Wave Alternans the Answer to Risk Stratification in Heart Failure? Circulation, December 18, 2007; 116(25): 2984 - 2991. [Full Text] [PDF]
|
|
|
|
|
|
R. S. Gardner, K. S. Chong, E. O'Meara, A. Jardine, I. Ford, and T. A. McDonagh Renal dysfunction, as measured by the modification of diet in renal disease equations, and outcome in patients with advanced heart failure Eur. Heart J., December 2, 2007; 28(24): 3027 - 3033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kioka, T. Yamada, T. Mine, T. Morita, Y. Tsukamoto, S. Tamaki, M. Masuda, K. Okuda, M. Hori, and M. Fukunami Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging Heart, October 1, 2007; 93(10): 1213 - 1218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maisel Biomarkers in Heart Failure: Does Prognostic Utility Translate to Clinical Futility? J. Am. Coll. Cardiol., September 11, 2007; 50(11): 1061 - 1063. [Full Text] [PDF]
|
|
|
|
|
|
H. Blangy, N. Sadoul, B. Dousset, A. Radauceanu, R. Fay, E. Aliot, and F. Zannad Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction Europace, September 1, 2007; 9(9): 724 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bayes-Genis, R. Vazquez, T. Puig, C. Fernandez-Palomeque, J. Fabregat, A. Bardaji, D. Pascual-Figal, J. Ordonez-Llanos, M. Valdes, A. Gabarrus, et al. Left atrial enlargement and NT-proBNP as predictors of sudden cardiac death in patients with heart failure Eur J Heart Fail, August 1, 2007; 9(8): 802 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.H. Wilson Tang, G. S. Francis, D. A. Morrow, L. K. Newby, C. P. Cannon, R. L. Jesse, A. B. Storrow, R. H. Christenson, COMMITTEE MEMBERS, R. H. Christenson, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure Circulation, July 31, 2007; 116(5): e99 - e109. [Full Text] [PDF]
|
|
|
|
|
|
C. Mueller The Use of B-Type Natriuretic Peptides in Coronary Artery Disease: Utile or Futile? J. Am. Coll. Cardiol., July 17, 2007; 50(3): 215 - 216. [Full Text] [PDF]
|
|
|
|
|
|
A. Struthers and C. Lang The potential to improve primary prevention in the future by using BNP/N-BNP as an indicator of silent 'pancardiac' target organ damage: BNP/N-BNP could become for the heart what microalbuminuria is for the kidney Eur. Heart J., July 2, 2007; 28(14): 1678 - 1682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Noda, H. Izawa, H. Asano, S. Nakata, A. Hirashiki, Y. Murase, S. Iino, K. Nagata, T. Murohara, Y. Koike, et al. Beneficial Effect of Bilevel Positive Airway Pressure on Left Ventricular Function in Ambulatory Patients With Idiopathic Dilated Cardiomyopathy and Central Sleep Apnea-Hypopnea: A Preliminary Study Chest, June 1, 2007; 131(6): 1694 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liang, J. O'Rear, U. Schellenberger, L. Tai, M. Lasecki, G. F. Schreiner, F. S. Apple, A. S. Maisel, N. S. Pollitt, and A. A. Protter Evidence for Functional Heterogeneity of Circulating B-Type Natriuretic Peptide J. Am. Coll. Cardiol., March 13, 2007; 49(10): 1071 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Gardner, K. S. Chong, J. J. Morton, and T. A. McDonagh A change in N-terminal pro-brain natriuretic peptide is predictive of outcome in patients with advanced heart failure Eur J Heart Fail, March 1, 2007; 9(3): 266 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Christ, J. Sharkova, S. Bayrakcioglu, I. Herzum, C. Mueller, and W. Grimm B-type natriuretic peptide levels predict event-free survival in patients with implantable cardioverter defibrillators Eur J Heart Fail, March 1, 2007; 9(3): 272 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Canter, R. E. Shaddy, D. Bernstein, D. T. Hsu, M. R.K. Chrisant, J. K. Kirklin, K. R. Kanter, R. S.D. Higgins, E. D. Blume, D. N. Rosenthal, et al. Indications for Heart Transplantation in Pediatric Heart Disease: A Scientific Statement From the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia; and the Quality of Care and Outcomes Research Interdisciplinary Working Group Circulation, February 6, 2007; 115(5): 658 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pitzalis, M. Iacoviello, M. Anaclerio, C. Forleo, F. Di Serio, L. Varraso, and N. Pansini Methodical approach to collecting and preserving plasma samples containing B-type natriuretic peptide Eur J Heart Fail, February 1, 2007; 9(2): 215 - 215. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bibbins-Domingo, R. Gupta, B. Na, A. H. B. Wu, N. B. Schiller, and M. A. Whooley N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP), Cardiovascular Events, and Mortality in Patients With Stable Coronary Heart Disease JAMA, January 10, 2007; 297(2): 169 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Konstam Natriuretic Peptides and Cardiovascular Events: More Than a Stretch JAMA, January 10, 2007; 297(2): 212 - 214. [Full Text] [PDF]
|
|
|
|
|
|
J. F. Price, A. K. Thomas, M. Grenier, B. W. Eidem, E. O. Smith, S. W. Denfield, J. A. Towbin, and W. J. Dreyer B-Type Natriuretic Peptide Predicts Adverse Cardiovascular Events in Pediatric Outpatients With Chronic Left Ventricular Systolic Dysfunction Circulation, September 5, 2006; 114(10): 1063 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Klingenberg, C Zugck, R Becker, D Schellberg, G Heinze, R Kell, A Remppis, W Schoels, H A Katus, and T J Dengler Raised B-type natriuretic peptide predicts implantable cardioverter-defibrillator therapy in patients with ischaemic cardiomyopathy. Heart, September 1, 2006; 92(9): 1323 - 1324. [Full Text] [PDF]
|
|
|
|
|
|
G. Klein, C. Lissel, A.-C. Fuchs, A. Gardiwal, H. Oswald, M. deSousa, A. M. Pichlmaier, R. Lichtinghagen, H. Geerlings, P. Lippolt, et al. Predictors of VT/VF-occurrence in ICD patients: results from the PROFIT-Study. Europace, August 1, 2006; 8(8): 618 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Masson, R. Latini, I. S. Anand, T. Vago, L. Angelici, S. Barlera, E. D. Missov, A. Clerico, G. Tognoni, J. N. Cohn, et al. Direct Comparison of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in a Large Population of Patients with Chronic and Symptomatic Heart Failure: The Valsartan Heart Failure (Val-HeFT) Data Clin. Chem., August 1, 2006; 52(8): 1528 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-C. Huang, E.-T. Wu, W.-J. Ko, L.-P. Lai, J. Hsu, C.-I. Chang, I.-S. Chiu, S.-S. Wang, M.-H. Wu, F.-Y. Lin, et al. Clinical Implication of Blood Levels of B-Type Natriuretic Peptide in Pediatric Patients on Mechanical Circulatory Support Ann. Thorac. Surg., June 1, 2006; 81(6): 2267 - 2272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Watanabe, T. Shinozaki, N. Shiba, K. Fukahori, Y. Koseki, A. Karibe, M. Sakuma, M. Miura, Y. Kagaya, and K. Shirato Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure Eur J Heart Fail, May 1, 2006; 8(3): 237 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.A. Gould, J. D'Agostino, H.G. Schneider, and D.M. Kaye Influence of atrial fibrillation on cardiac brain natriuretic peptide release during haemodynamic stress in heart failure Eur J Heart Fail, May 1, 2006; 8(3): 263 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hirashiki, H. Izawa, F. Somura, K. Obata, T. Kato, T. Nishizawa, A. Yamada, H. Asano, S. Ohshima, A. Noda, et al. Prognostic Value of Pacing-Induced Mechanical Alternans in Patients With Mild-to-Moderate Idiopathic Dilated Cardiomyopathy in Sinus Rhythm J. Am. Coll. Cardiol., April 4, 2006; 47(7): 1382 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Januzzi Jr, R. Sakhuja, M. O'Donoghue, A. L. Baggish, S. Anwaruddin, C. U. Chae, R. Cameron, D. G. Krauser, R. Tung, C. A. Camargo Jr, et al. Utility of amino-terminal pro-brain natriuretic Peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department. Arch Intern Med, February 13, 2006; 166(3): 315 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Anderson B-type natriuretic peptide: a role in selection and follow up of the implantable cardioverter-defibrillator patient? Heart, February 1, 2006; 92(2): 147 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Verma, F Kilicaslan, D O Martin, S Minor, R Starling, N F Marrouche, S Almahammed, O M Wazni, S Duggal, R Zuzek, et al. Preimplantation B-type natriuretic peptide concentration is an independent predictor of future appropriate implantable defibrillator therapies Heart, February 1, 2006; 92(2): 190 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G A Wright and A D Struthers Natriuretic peptides as a prognostic marker and therapeutic target in heart failure Heart, February 1, 2006; 92(2): 149 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Fallavollita, B. J. Riegel, G. Suzuki, U. Valeti, and J. M. Canty Jr. Mechanism of sudden cardiac death in pigs with viable chronically dysfunctional myocardium and ischemic cardiomyopathy Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2688 - H2696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Manios, E. M. Kallergis, E. M. Kanoupakis, H. E. Mavrakis, D. C. Kambouraki, D. A. Arfanakis, and P. E. Vardas Amino-Terminal Pro-Brain Natriuretic Peptide Predicts Ventricular Arrhythmogenesis in Patients With Ischemic Cardiomyopathy and Implantable Cardioverter-Defibrillators Chest, October 1, 2005; 128(4): 2604 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Meyer, D. Mortl, K. Strecker, M. Hulsmann, V. Kulemann, T. Neunteufl, R. Pacher, and R. Berger Flow-Mediated Vasodilation Predicts Outcome in Patients With Chronic Heart Failure: Comparison With B-Type Natriuretic Peptide J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1011 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Suttner, K. Lang, S. N. Piper, H. Schultz, K. D. Rohm, and J. Boldt Continuous Intra- and Postoperative Thoracic Epidural Analgesia Attenuates Brain Natriuretic Peptide Release After Major Abdominal Surgery Anesth. Analg., September 1, 2005; 101(3): 896 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jefic, J. W. Lee, D. Jefic, R. T. Savoy-Moore, and H. S. Rosman Utility of B-Type Natriuretic Peptide and N-terminal Pro B-Type Natriuretic Peptide in Evaluation of Respiratory Failure in Critically Ill Patients Chest, July 1, 2005; 128(1): 288 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schillinger Editorial Comment--Brain Natriuretic Peptide and Early Cardiac Dysfunction After Subarachnoid Hemorrhage Stroke, July 1, 2005; 36(7): 1570 - 1571. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Luchner, C. Hengstenberg, H. Lowel, G. A.J. Riegger, H. Schunkert, and S. Holmer Effect of Compensated Renal Dysfunction on Approved Heart Failure Markers: Direct Comparison of Brain Natriuretic Peptide (BNP) and N-Terminal Pro-BNP Hypertension, July 1, 2005; 46(1): 118 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Davis, N. M. Albert, and J. B. Young Palliation of heart failure American Journal of Hospice and Palliative Medicine, May 1, 2005; 22(3): 211 - 222. [Abstract] [PDF]
|
|
|
|
|
|
C. Carmona-Bernal, E. Quintana-Gallego, M. Villa-Gil, A. Sanchez-Armengol, A. Martinez-Martinez, and F. Capote Brain Natriuretic Peptide in Patients With Congestive Heart Failure and Central Sleep Apnea Chest, May 1, 2005; 127(5): 1667 - 1673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E Lane, M. R Cowie, and A. W C Chow Prediction and prevention of sudden cardiac death in heart failure Heart, May 1, 2005; 91(5): 674 - 680. [Full Text] [PDF]
|
|
|
|
|
|
C. Kistorp, I. Raymond, F. Pedersen, F. Gustafsson, J. Faber, and P. Hildebrandt N-Terminal Pro-Brain Natriuretic Peptide, C-Reactive Protein, and Urinary Albumin Levels as Predictors of Mortality and Cardiovascular Events in Older Adults JAMA, April 6, 2005; 293(13): 1609 - 1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schillinger Cardiovascular Risk Stratification in Older Patients: Role of Brain Natriuretic Peptide, C-Reactive Protein, and Urinary Albumin Levels JAMA, April 6, 2005; 293(13): 1667 - 1669. [Full Text] [PDF]
|
|
|
|
 |
|
 J. A Doust, E. Pietrzak, A. Dobson, and P. Glasziou How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review BMJ, March 19, 2005; 330(7492): 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Gardner, V. Chong, I. Morton, and T. A. McDonagh N-terminal brain natriuretic peptide is a more powerful predictor of mortality than endothelin-1, adrenomedullin and tumour necrosis factor-{alpha} in patients referred for consideration of cardiac transplantation Eur J Heart Fail, March 2, 2005; 7(2): 253 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A.H. Stewart Broader indications for B-type natriuretic peptide testing in coronary artery disease Eur. Heart J., February 1, 2005; 26(3): 207 - 209. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Silva, A. W. Chan, C. J. White, T. J. Collins, J. S. Jenkins, J. P. Reilly, and S. R. Ramee Elevated Brain Natriuretic Peptide Predicts Blood Pressure Response After Stent Revascularization in Patients With Renal Artery Stenosis Circulation, January 25, 2005; 111(3): 328 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Williams, L. L. Ng, R. J. O'Brien, S. Taylor, D. J. Wright, and L.-B. Tan Is plasma N-BNP a good indicator of the functional reserve of failing hearts? The FRESH-BNP study Eur J Heart Fail, December 1, 2004; 6(7): 891 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. McCord, B. J. Mundy, M. P. Hudson, A. S. Maisel, J. E. Hollander, W. T. Abraham, P. G. Steg, T. Omland, C. W. Knudsen, K. R. Sandberg, et al. Relationship Between Obesity and B-Type Natriuretic Peptide Levels Arch Intern Med, November 8, 2004; 164(20): 2247 - 2252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lim, J. L. Monin, M. Monchi, J. Garot, A. Pasquet, L. Hittinger, J. L. Vanoverschelde, A. Carayon, and P. Gueret Predictors of outcome in patients with severe aortic stenosis and normal left ventricular function: role of B-type natriuretic peptide Eur. Heart J., November 2, 2004; 25(22): 2048 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Campana, M. Pasotti, L. Monti, M. Revera, A. Serio, L. Nespoli, G. Magrini, L. Scelsi, S. Ghio, and L. Tavazzi The evaluation of right ventricular performance in different clinical models of heart failure Eur. Heart J. Suppl., November 1, 2004; 6(suppl_F): F61 - F67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ohuchi, H. Takasugi, H. Ohashi, O. Yamada, K. Watanabe, T. Yagihara, and S. Echigo Abnormalities of Neurohormonal and Cardiac Autonomic Nervous Activities Relate Poorly to Functional Status in Fontan Patients Circulation, October 26, 2004; 110(17): 2601 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Tomaselli and D. P. Zipes What Causes Sudden Death in Heart Failure? Circ. Res., October 15, 2004; 95(8): 754 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M T Kearney, K A A Fox, A J Lee, W P Brooksby, A M Shah, A Flapan, R J Prescott, R Andrews, P D Batin, D L Eckberg, et al. Predicting sudden death in patients with mild to moderate chronic heart failure Heart, October 1, 2004; 90(10): 1137 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Suzuki, M. Yoshimura, M. Nakayama, Y. Mizuno, E. Harada, T. Ito, S. Nakamura, K. Abe, M. Yamamuro, T. Sakamoto, et al. Plasma Level of B-Type Natriuretic Peptide as a Prognostic Marker After Acute Myocardial Infarction: A Long-Term Follow-Up Analysis Circulation, September 14, 2004; 110(11): 1387 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Jernberg, S. James, B. Lindahl, N. Johnston, M. Stridsberg, P. Venge, and L. Wallentin Natriuretic peptides in unstable coronary artery disease Eur. Heart J., September 1, 2004; 25(17): 1486 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Rodeheffer Measuring plasma B-type natriuretic peptide in heart failure: Good to go in 2004? J. Am. Coll. Cardiol., August 18, 2004; 44(4): 740 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Z. Pantilat and A. E. Steimle Palliative Care for Patients With Heart Failure JAMA, May 26, 2004; 291(20): 2476 - 2482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bergler-Klein, U. Klaar, M. Heger, R. Rosenhek, G. Mundigler, H. Gabriel, T. Binder, R. Pacher, G. Maurer, and H. Baumgartner Natriuretic Peptides Predict Symptom-Free Survival and Postoperative Outcome in Severe Aortic Stenosis Circulation, May 18, 2004; 109(19): 2302 - 2308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J DiDomenico, H. Y Park, M. R. Southworth, H. M Eyrich, R. K Lewis, J. M Finley, and G. T Schumock Guidelines for Acute Decompensated Heart Failure Treatment Ann. Pharmacother., April 1, 2004; 38(4): 649 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bettencourt NT-proBNP and BNP: biomarkers for heart failure management Eur J Heart Fail, March 15, 2004; 6(3): 359 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Tapanainen, K. S. Lindgren, T. H. Makikallio, O. Vuolteenaho, J. Leppaluoto, and H. V. Huikuri Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myocardial infarction in the beta-blocking era J. Am. Coll. Cardiol., March 3, 2004; 43(5): 757 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J H McGowan Hibernating myocardium: high or low risk? Heart, March 1, 2004; 90(3): 237 - 238. [Full Text] [PDF]
|
|
|
|
|
|
D. Logeart, G. Thabut, P. Jourdain, C. Chavelas, P. Beyne, F. Beauvais, E. Bouvier, and A. C. Solal Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure J. Am. Coll. Cardiol., February 18, 2004; 43(4): 635 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Wang, M. G. Larson, D. Levy, E. J. Benjamin, E. P. Leip, T. Omland, P. A. Wolf, and R. S. Vasan Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death N. Engl. J. Med., February 12, 2004; 350(7): 655 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. de Denus, C. Pharand, and D. R. Williamson Brain Natriuretic Peptide in the Management of Heart Failure: The Versatile Neurohormone Chest, February 1, 2004; 125(2): 652 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kyuma, T. Nakata, A. Hashimoto, K. Nagao, H. Sasao, T. Takahashi, K. Tsuchihashi, and K. Shimamoto Incremental Prognostic Implications of Brain Natriuretic Peptide, Cardiac Sympathetic Nerve Innervation, and Noncardiac Disorders in Patients with Heart Failure J. Nucl. Med., February 1, 2004; 45(2): 155 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Prahash and T. Lynch B-Type Natriuretic Peptide: A Diagnostic, Prognostic, and Therapeutic Tool in Heart Failure Am. J. Crit. Care., January 1, 2004; 13(1): 46 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Vourvouri, A. F.L. Schinkel, J. R.T.C. Roelandt, F. Boomsma, G. Sianos, M. Bountioukos, F. B. Sozzi, V. Rizzello, J. J. Bax, H. I. Karvounis, et al. Screening for left ventricular dysfunction using a hand-carried cardiac ultrasound device Eur J Heart Fail, December 1, 2003; 5(6): 767 - 774. [Abstract] [Full Text] [PDF]
|
|