Circulation. 2002;105:200-206
doi: 10.1161/hc0202.102246
doi: 10.1161/hc0202.102246
(Circulation. 2002;105:200.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Predicting Death in Patients With Acute Type A Aortic Dissection
From the University of Michigan (R.H.M., P.G.H., J.V.C., D.E., W.F.A., K.A.E.), Ann Arbor; University of Tokyo (T.S.), Japan; Instituto Policlinico San Donato (E.B.), Milan, Italy; Hadassah University Hospital (D.G.), Jerusalem, Israel; Hospital Universitario "12 de Octubre" (A.L., L.C.M.), Madrid, Spain; and University of Rostock (C.A.N.), Germany.
Correspondence to Kim A. Eagle, MD, University of Michigan, 3910 TC, Ann Arbor, MI 48109. E-mail keagle{at}umich.edu
Background— Given the high mortality rates in patients with type A aortic dissection, predictive tools to identify patients at increased risk of death are needed to assist clinicians for optimal treatment.
Methods and Results— Accordingly, we evaluated 547 patients with this diagnosis enrolled in the International Registry of Acute Aortic Dissection (IRAD) between January 1996 and December 1999. Univariate testing followed by multivariate logistic regression analysis was performed to identify independent predictors of death. In-hospital mortality rate was 32.5% in type A dissection patients. In-hospital complications (neurological deficits, altered mental status, myocardial or mesenteric ischemia, kidney failure, hypotension, cardiac tamponade, and limb ischemia) were increased in patients who died compared with survivors (P<0.05 for all). Logistic regression identified the following presenting variables as predictors of death: age 
70 years (OR, 1.70; 95% CI, 1.05 to 2.77; P=0.03), abrupt onset of chest pain (OR 2.60; 95% CI, 1.22 to 5.54; P=0.01), hypotension/shock/tamponade (OR, 2.97; 95% CI, 1.83 to 4.81; P<0.0001), kidney failure (OR, 4.77; 95% CI, 1.80 to 12.6; P=0.002), pulse deficit (OR, 2.03; 95% CI, 1.25 to 3.29, P=0.004), and abnormal ECG (OR, 1.77; 95% CI, 1.06 to 2.95; P=0.03) (area under receiver operating curve, 0.74; Hosmer-Lemeshow statistic, P=0.75).
Conclusions— The in-hospital mortality rate in acute type A aortic dissection is high and can be predicted with the use of a clinical model incorporated in a simple risk prediction tool. This tool can be used to educate patients with dissection about their predicted risk and in clinical research for risk adjustment while comparing outcomes of different therapies.
Key Words: aorta • mortality • surgery • risk factors
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