Circulation. 2002;105:1760-1763
Published online before print March 25, 2002, doi: 10.1161/01.CIR.0000015464.18023.0A
Published online before print March 25, 2002, doi: 10.1161/01.CIR.0000015464.18023.0A
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(Circulation. 2002;105:1760.)
© 2002 American Heart Association, Inc.
Brief Rapid Communications |
Multimarker Approach to Risk Stratification in Non-ST Elevation Acute Coronary Syndromes
Simultaneous Assessment of Troponin I, C-Reactive Protein, and B-Type Natriuretic Peptide
From the TIMI Study Group (M.S.S., D.A.M., C.M., E.M.A., C.P.C., E.B.), Cardiovascular Division, Brigham and Women’s Hospital, Boston, Mass; UT-Southwestern Medical School (J.A.d.L.), Dallas, Tex; Harvard Clinical Research Institute (C.M.G., S.A.M.), Boston, Mass; and Children’s Hospital (N.R.), Boston, Mass.
Correspondence to Marc S. Sabatine, MD, TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115. E-mail msabatine{at}partners.org
Background— In patients with acute coronary syndromes (ACS), troponin I (TnI), C-reactive protein (CRP), and B-type natriuretic peptide (BNP) each predict adverse cardiac events. Little is known, however, about the utility of these biomarkers in combination.
Methods and Results— Baseline measurements of TnI, CRP, and BNP were performed in 450 patients in OPUS-TIMI 16. Elevations in TnI, CRP, and BNP each were independent predictors of the composite of death, myocardial infarction (MI), or congestive heart failure (CHF). When patients were categorized on the basis of the number of elevated biomarkers at presentation, there was a near doubling of the mortality risk for each additional biomarker that was elevated (P=0.01). Similar relationships existed for the endpoints of MI, CHF, and the composite, both at 30 days and through 10 months. In a validation cohort of 1635 patients in TACTICS-TIMI 18, the number of elevated biomarkers remained a significant predictor of the composite endpoint after adjustment for known clinical predictors: patients with one, two, and three elevated biomarkers had a 2.1- (P=0.006), 3.1- (P<0.001), and 3.7- (P=0.001) fold increase in the risk of death, MI, or CHF by 6 months.
Conclusions— Troponin, CRP, and BNP each provide unique prognostic information in patients with ACS. A simple multimarker strategy that categorizes patients based on the number of elevated biomarkers at presentation allows risk stratification over a broad range of short- and long-term major cardiac events.
Key Words: coronary disease • prognosis • myocardial infarction • inflammation • natriuretic peptides
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|
|
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|
|
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|
|
|
|
|
|
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|
|
|
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|
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|
|
|
|
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|
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|
|
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|
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|
|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
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|
 R. Minkin, D. Cotiga, S. Noack, A. Dobrescu, P. Homel, and J. M. Shapiro Use of Admission Troponin in Critically Ill Medical Patients J Intensive Care Med, December 1, 2005; 20(6): 286 - 290. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 A. Elsasser and C. W. Hamm Percutaneous coronary intervention guidelines: new aspects for the interventional treatment of acute coronary syndromes Eur. Heart J. Suppl., October 1, 2005; 7(suppl_K): K5 - K9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 S. Suttner, K. Lang, S. N. Piper, H. Schultz, K. D. Rohm, and J. Boldt Continuous Intra- and Postoperative Thoracic Epidural Analgesia Attenuates Brain Natriuretic Peptide Release After Major Abdominal Surgery Anesth. Analg., September 1, 2005; 101(3): 896 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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|
|