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(Circulation. 2001;104:I-68.)
© 2001 American Heart Association, Inc.

Surgery for Coronary Artery Disease

Does Coronary Artery Bypass Grafting Alone Correct Moderate Ischemic Mitral Regurgitation?

Lishan Aklog, MD; Farzan Filsoufi, MD; Kathryn Q. Flores, MD; Raymond H. Chen, MD; Lawrence H. Cohn, MD; Nadia S. Nathan, MD; John G. Byrne, MD; David H. Adams, MD

Divisions of Cardiac Surgery and Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass.

Correspondence to Lishan Aklog, MD, Division of Cardiac Surgery, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115. E-mail laklog{at}partners.org

Background— The optimal management of moderate (3+ on a scale of 0 to 4+) ischemic mitral regurgitation (MR) remains controversial. Some advocate CABG alone, whereas others favor concomitant mitral annuloplasty. To clarify the optimal management of these patients, we evaluated the early impact of isolated CABG on moderate ischemic MR.

Methods and Results— Between January 1992 and August 1999, 136 patients (54% male, mean age 70.5 years, mean New York Heart Association class 2.7, mean ejection fraction 38.1%) with a preoperative diagnosis of moderate ischemic MR, without leaflet prolapse or pathology, underwent isolated CABG. Thirty-eight (28%) of 136 patients had intraoperative transesophageal echocardiography (TEE) before CABG, and 68 (50%) had postoperative transthoracic echocardiography (TTE) within 6 weeks of surgery. The subgroups of patients undergoing intraoperative TEE and postoperative TTE had preoperative characteristics similar to the overall group. The 30-day operative mortality was 2.9% (). Intraoperative TEE downgraded the severity of MR to mild or less (0 to 2+) in 89% (). On postoperative TTE, 40% () continued to have at least moderate MR (3 to 4+), 51% () improved somewhat to mild (2+) MR, and only 9% () had resolution of their MR (0 to 1+). The mean preoperative, intraoperative, and postoperative MR grades were 3.0±0.0, 1.4±1.0, and 2.3±0.8, respectively (P<0.001).

Conclusions— CABG alone for moderate ischemic MR leaves many patients with significant residual MR and may not be the optimal therapy for most patients. Intraoperative TEE may significantly underestimate the severity of ischemic MR. A preoperative diagnosis of moderate MR may warrant concomitant mitral annuloplasty.

Key Words: coronary disease • echocardiography • mitral valve • regurgitation • surgery