(Circulation. 2000;102:2919.)
© 2000 American Heart Association, Inc.
Brief Rapid Communications |
Transfer of CD4+ T Cells Aggravates Atherosclerosis in Immunodeficient Apolipoprotein E Knockout Mice
From the Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden (X.Z., R.E., G.K.H.), and INSERM U430, Hôpital Broussais, Paris, France (A.N.).
Correspondence to Dr Göran K. Hansson, Center for Molecular Medicine L8:03, Karolinska Hospital, SE-17176 Stockholm, Sweden. E-mail Goran.Hansson{at}cmm.ki.se
Background—Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear.
Methods and Results—To
study the role of immunity in atherosclerosis, we
crossed atherosclerosis-prone
apoE—/– mice with immunodeficient
scid/scid mice. The offspring
showed a 73% reduction in aortic fatty streak lesions when compared
with immunocompetent apoE–/– mice.
Transfer of CD4+ T cells from
apoE–/– to immunodeficient
apoE–/–/scid/scid
mice increased lesions by 164%. This was associated with the
infiltration of transferred T cells into lesions, increased circulating
interferon-
levels, and increased I-A expression in
lesions.
Conclusions—CD4+ T cells carry disease-promoting immunity in atherosclerosis.
Key Words: atherosclerosis • lymphocytes • immune system • mice, knockout
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