(Circulation. 2000;102:2713.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure
From the Departments of Medicine, Surgery, and Biomedical Engineering, Columbia University, New York, NY.
Correspondence to Paul M. Heerdt, MD, PhD, New York Presbyterian Hospital, 525 East 68th St, Lasdon 2, Box 50, New York, NY 10021. E-mail pmheerd{at}mail.med.cornell.edu
Background—Left ventricular (LV) assist devices (LVADs) can improve contractile strength and normalize characteristics of the Ca2+ transient in myocytes isolated from failing human hearts. The purpose of the present study was to determine whether LVAD support also improves contractile strength at different frequencies of contraction (the force-frequency relationship [FFR]) of intact myocardium and alters the expression of genes encoding for proteins involved in Ca2+ handling.
Methods and Results—The isometric FFRs of LV trabeculae isolated from 15 patients with end-stage heart failure were compared with those of 7 LVAD-supported patients and demonstrated improved contractile force at 1-Hz stimulation, with reversal of a negative FFR after LVAD implantation. In 20 failing hearts, Northern blot analysis for sarcoplasmic endoreticular Ca2+-ATPase subtype 2a (SERCA2a), the ryanodine receptor, and the sarcolemmal Na+-Ca2+ exchanger was performed on LV tissue obtained before and after LVAD implantation. These paired data demonstrated an upregulation of all 3 genes after LVAD support. In tissue obtained from subsets of these patients, Western blot analysis was performed, and oxalate-supported Ca2+ uptake by isolated sarcoplasmic reticular membranes was determined. Despite higher mRNA for all genes after LVAD support, only SERCA2a protein was increased. Functional significance of increased SERCA2a was confirmed by augmented Ca2+ uptake by sarcoplasmic reticular membranes isolated from LVAD-supported hearts.
Conclusions—LVAD support can improve contractile strength of intact myocardium and reverse the negative FFR associated with end-stage heart failure. The expression of genes encoding for proteins involved in Ca2+ cycling is upregulated (reverse molecular remodeling), but only the protein content of SERCA2a is increased.
Key Words: heart failure • sarcoplasmic reticulum • calcium • genes • heart-assist device
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 L. Elsherif, L. Wang, J. T. Saari, and Y. J. Kang Regression of Dietary Copper Restriction-Induced Cardiomyopathy by Copper Repletion in Mice J. Nutr., April 1, 2004; 134(4): 855 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 J. M. Guccione, A. Salahieh, S. M. Moonly, J. Kortsmit, A. W. Wallace, and M. B. Ratcliffe Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study Ann. Thorac. Surg., October 1, 2003; 76(4): 1171 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. BORLAK and T. THUM Hallmarks of ion channel gene expression in end-stage heart failure FASEB J, September 1, 2003; 17(12): 1592 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
J. K. F. Hon and M. H. Yacoub Bridge to recovery with the use of left ventricular assist device and clenbuterol Ann. Thorac. Surg., June 1, 2003; 75(90060): S36 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M. R. Bristow Microarray measurements of gene expression before and after left ventricular assist device placement J. Am. Coll. Cardiol., April 2, 2003; 41(7): 1107 - 1108. [Full Text] [PDF]
|
|
|
|
|
|
S. R. Houser and K. B. Margulies Is Depressed Myocyte Contractility Centrally Involved in Heart Failure? Circ. Res., March 7, 2003; 92(4): 350 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ito, M. Nakayama, F. Hasan, X. Yan, M. D. Schneider, and B. H. Lorell Contractile Reserve and Calcium Regulation Are Depressed in Myocytes From Chronically Unloaded Hearts Circulation, March 4, 2003; 107(8): 1176 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Tevaearai, G. B. Walton, A. D. Eckhart, J. R. Keys, and W. J. Koch Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts J. Thorac. Cardiovasc. Surg., December 1, 2002; 124(6): 1149 - 1156. [Abstract] [Full Text]
|
|
|
|
|
|
X. Chen, V. Piacentino III, S. Furukawa, B. Goldman, K. B. Margulies, and S. R. Houser L-Type Ca2+ Channel Density and Regulation Are Altered in Failing Human Ventricular Myocytes and Recover After Support With Mechanical Assist Devices Circ. Res., September 20, 2002; 91(6): 517 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
K. R Sipido, P. G.A Volders, M. A Vos, and F. Verdonck Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc Res, March 1, 2002; 53(4): 782 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Harding, V. Piacentino III, J. P. Gaughan, S. R. Houser, and K. B. Margulies Electrophysiological Alterations After Mechanical Circulatory Support in Patients With Advanced Cardiac Failure Circulation, September 11, 2001; 104(11): 1241 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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