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(Circulation. 2000;102:149.)
© 2000 American Heart Association, Inc.

Clinical Investigation and Reports

Oral Glycoprotein IIb/IIIa Inhibition With Orbofiban in Patients With Unstable Coronary Syndromes (OPUS-TIMI 16) Trial

Christopher P. Cannon, MD; Carolyn H. McCabe, BS; Robert G. Wilcox, MD; Anatoly Langer, MD; Abraham Caspi, MD; Peter Berink, MD; Jose Lopez-Sendon, MD; Jiri Toman, MD; Andrew Charlesworth, BSc; Robert J. Anders, PharmD; John C. Alexander, MD; Allan Skene, PhD; Eugene Braunwald, MD; for the OPUS-TIMI 16 Investigators

From Brigham and Women’s Hospital, Boston, Mass (C.P.C., C.H.M., E.B.); Queen’s Medical Centre, UK (R.G.W.); St Michael’s Hospital, Toronto, Canada (A.L.); Kaplan Medical Center, Israel (A.C.); Martini Ziekenhuis, The Netherlands (P.B.); Hospital Gregorio Maranon, Spain (J.L.-S.); University Hospital of St Anna, Czech Republic (J.T.); Nottingham Clinical Research Group, Nottingham, UK (A.C., A.S.); and Searle, Skokie, Ill (R.J.A., J.C.A.).

Background—Although intravenous glycoprotein IIb/IIIa inhibitors are beneficial in patients with acute coronary syndromes, prolonged oral IIb/IIIa inhibition might provide an additional reduction in recurrent events.

Methods and Results—Investigators at 888 hospitals in 29 countries enrolled 10 288 patients with acute coronary syndromes, which was defined as ischemic pain at rest within 72 hours of randomization, associated with positive cardiac markers, electrocardiographic changes, or prior cardiovascular disease. Patients received aspirin and were randomized to receive, for the duration of the trial, (1) 50 mg of orbofiban twice daily (50/50 group), (2) 50 mg of orbofiban twice daily for 30 days followed by 30 mg of orbofiban twice daily (50/30 group), or (3) a placebo. The primary composite end point was death, myocardial infarction, recurrent ischemia requiring rehospitalization, urgent revascularization, or stroke. The trial was terminated prematurely because of an unexpected increase in 30-day mortality in the 50/30 orbofiban group. Mortality through 10 months was 3.7% for the placebo group versus 5.1% in the 50/30 group (P=0.008) and 4.5% in the 50/50 group (P=0.11). There were no differences in the primary end point (22.9%, 23.1%, and 22.8%, for the placebo, 50/30, and 50/50 groups, respectively). Major or severe bleeding (but not intracranial hemorrhage) was higher with orbofiban; it occurred in 2.0%, 3.7% (P=0.0004), and 4.5% (P<0.0001) of patients, respectively. Exploratory subgroup analyses found that patients who underwent percutaneous coronary intervention had a lower mortality and a significant reduction in the composite end point (P=0.001) with orbofiban.

Conclusions—Fixed-dose orbofiban failed to reduce major cardiovascular events and was associated with increased mortality in this broad population of patients with acute coronary syndromes; however, a benefit was observed among patients who underwent percutaneous coronary intervention.

Key Words: coronary disease • myocardial infarction • heart diseases • stroke • platelet aggregation inhibitors

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