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(Circulation. 2000;102:1536.)
© 2000 American Heart Association, Inc.

Clinical Investigation and Reports

Relationship Between Circadian Blood Pressure Patterns and Progression of Early Carotid Atherosclerosis

A 3-Year Follow-Up Study

Dirk Sander, MD; Christian Kukla, MD; Jürgen Klingelhöfer, MD; Kerstin Winbeck, MD; Bastian Conrad, MD

From the Department of Neurology (D.S., C.K., K.W., B.C.), Technical University of Munich, Germany; and Klinikum Chemnitz (J.K.), Chemnitz, Germany.

Correspondence to Dr Dirk Sander, Department of Neurology, Technical University of Munich, Möhlstraße 28, 81675 München, Germany. E-mail Dirk.Sander{at}neuro.med.tu-muenchen.de

Background—Arterial hypertension is a major risk factor for cardiovascular damage. The results of several studies suggest that target organ damage is greater in hypertensive persons with high blood pressure variability.

Methods and Results—During 3.3 years of follow-up, we studied the relationship between circadian blood pressure changes and the progression of early carotid atherosclerosis in 286 patients aged >55 years. Blood pressure patterns were evaluated with a long-term blood pressure monitor, and the extent of atherosclerosis was measured as the intima-media wall thickness (IMT) of the common carotid artery. Patients were subdivided according to blood pressure variability. The progression of IMT was significantly greater in the patients with increased systolic blood pressure variability (0.11 mm/y [95% CI 0.09 to 0.14] versus 0.05 mm/y [0.03 to 0.08]; P<0.005) even after adjustment for other risk factors. Multivariate regression analysis revealed the daytime systolic blood pressure variability to be the best predictor for the progression of IMT. Raised daytime systolic blood pressure variability (>15 mm Hg) is associated with an increased relative risk of the development of early atherosclerosis (3.9 [1.4 to 11.1]; P<0.01) and of cardiovascular events (1.87 [1.08 to 3.20]; P<0.01).

Conclusions—The daytime systolic blood pressure variability is a strong predictor of early carotid atherosclerosis progression and is useful to define the risk-benefit ratio of therapeutic approaches.

Key Words: blood pressure • intima-media thickness • carotid arteries • ultrasonics • cardiovascular diseases

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