(Circulation. 2000;101:541.)
© 2000 American Heart Association, Inc.
Basic Science Reports |
Soluble Complement Receptor-1 Protects Heart, Lung, and Cardiac Myofilament Function From Cardiopulmonary Bypass Damage
From the Departments of Surgery (P.J.C., D.M.C., G.Q., J.J., R.M.U.) and Pediatrics, Division of Pediatric Cardiology (R.N., A.E.O., S.P.S., P.A.W.A.), Duke University, Durham, NC.
Correspondence to Page A.W. Anderson, MD, DUMC, Box 3218, Durham, NC 27710. E-mail ander005{at}mc.duke.edu
Background—Host defense system activation occurs with cardiopulmonary bypass (CPB) and is thought to contribute to the pathophysiological consequences of CPB. Complement inhibition effects on the post-CPB syndrome were tested with soluble complement receptor-1 (sCR1).
Methods and Results—Twenty neonatal pigs (weight 1.8 to 2.8 kg)
were randomized to control and sCR1-treated groups. LV pressure and
volume, left atrial pressure, pulmonary artery pressure and
flow, and respiratory system compliance and resistance were measured.
Preload recruitable stroke work, isovolumic diastolic
relaxation time constant (
), and pulmonary vascular
resistance were determined. Pre-CPB measures were not statistically
significantly different between the 2 groups. After CPB, preload
recruitable stroke work was significantly higher in the sCR1 group
(n=5, 46.8±3.2x103 vs n=6, 34.3±3.7x103
erg/cm3, P=0.042); was significantly
lower in the sCR1 group (26.4±1.5, 42.4±6.6 ms,
P=0.003); pulmonary vascular resistance was
significantly lower in the sCR1 group (5860±1360 vs 12 170±1200
dyn · s/cm5, P=0.009);
arterial PO2 in 100%
FIO2 was significantly higher in the sCR1 group
(406±63 vs 148±33 mm Hg, P=0.01); lung
compliance and airway resistance did not differ significantly. The
post-CPB Hill coefficient of atrial myocardium was higher
in the sCR1 group (2.88±0.29 vs 1.88±0.16,
P=0.023).
Conclusions—sCR1 meaningfully moderates the post-CPB syndrome, supporting the hypothesis that complement activation contributes to this syndrome.
Key Words: cardiopulmonary bypass • diastole • myofilaments • calcium
This article has been cited by other articles:
 |
|
 |
|
  A. Colli, C. Fernandez, L. Delgado, B. Romero, M. L. Camara, and X. Ruyra Aortic valve replacement with minimal extracorporeal circulation versus standard cardiopulmonary bypass Interactive CardioVascular and Thoracic Surgery, October 1, 2009; 9(4): 583 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ramaglia, R. Wolterman, M. de Kok, M. A. Vigar, I. Wagenaar-Bos, R. H. M. King, B. P. Morgan, and F. Baas Soluble Complement Receptor 1 Protects the Peripheral Nerve from Early Axon Loss after Injury Am. J. Pathol., April 1, 2008; 172(4): 1043 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Buyukates, S Acikgoz, O Kandemir, E Aktunc, E Ceylan, and M Can Use of warm priming solution in open heart surgery: its effects on hemodynamics and acute inflammation Perfusion, March 1, 2008; 23(2): 89 - 94. [Abstract] [PDF]
|
|
|
|
 |
|
 J. W. Hammon Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation Card. Surg. Adult, January 1, 2008; 3(2008): 370 - 389. [Full Text]
|
|
|
|
 |
|
 K. Baig, R. Nassar, D. M. Craig, G. Quick Jr, H. X. Jiang, M. M. Frank, A. J. Lodge, P. A.W. Anderson, and J. Jaggers Complement Factor 1 Inhibitor Improves Cardiopulmonary Function in Neonatal Cardiopulmonary Bypass Ann. Thorac. Surg., April 1, 2007; 83(4): 1477 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Suber, M. C. Carroll, and F. D. Moore Jr. Innate response to self-antigen significantly exacerbates burn wound depth PNAS, March 6, 2007; 104(10): 3973 - 3977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Castiglioni, A. Verzini, F. Pappalardo, N. Colangelo, L. Torracca, A. Zangrillo, and O. Alfieri Minimally Invasive Closed Circuit Versus Standard Extracorporeal Circulation for Aortic Valve Replacement Ann. Thorac. Surg., February 1, 2007; 83(2): 586 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kozik and J. S. Tweddell Characterizing the Inflammatory Response to Cardiopulmonary Bypass in Children Ann. Thorac. Surg., June 1, 2006; 81(6): S2347 - S2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Schultz, T. Karamlou, J. Swanson, I. Shen, and R. M. Ungerleider Hypothermic Low-Flow Cardiopulmonary Bypass Impairs Pulmonary and Right Ventricular Function More Than Circulatory Arrest Ann. Thorac. Surg., February 1, 2006; 81(2): 474 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rhen and J. A. Cidlowski Estrogens and Glucocorticoids Have Opposing Effects on the Amount and Latent Activity of Complement Proteins in the Rat Uterus Biol Reprod, February 1, 2006; 74(2): 265 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhang, E. M. Alicot, I. Chiu, J. Li, N. Verna, T. Vorup-Jensen, B. Kessler, M. Shimaoka, R. Chan, D. Friend, et al. Identification of the target self-antigens in reperfusion injury J. Exp. Med., January 23, 2006; 203(1): 141 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chong, C. R. Hampton, and E. D. Verrier Microvascular Inflammatory Response in Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 333 - 354. [Abstract] [PDF]
|
|
|
|
|
|
P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]
|
|
|
|
 |
|
 Y. Fromes, D. Gaillard, O. Ponzio, M. Chauffert, M.-F. Gerhardt, P. Deleuze, and O. M. Bical Reduction of the inflammatory response following coronary bypass grafting with total minimal extracorporeal circulation Eur. J. Cardiothorac. Surg., October 1, 2002; 22(4): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N Peterson, R. Nassar, P. A W Anderson, and N. R Alpert Altered cross-bridge characteristics following haemodynamic overload in rabbit hearts expressing V3 myosin J. Physiol., October 15, 2001; 536(2): 569 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fung, P. G. Loubser, A. Undar, M. Mueller, C. Sun, W. N. Sun, W. K. Vaughn, and C. D. Fraser Jr Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits J. Thorac. Cardiovasc. Surg., July 1, 2001; 122(1): 113 - 122. [Abstract] [Full Text] [PDF]
|
|