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(Circulation. 1999;100:II-84.)
© 1999 American Heart Association, Inc.

Surgery for Valvular Heart Disease

Mitral Valve Replacement or Repair After Previous Coronary Artery Bypass Grafting

Uzi Izhar, MD; Richard C. Daly, MD; Joseph A. Dearani, MD; Thomas A. Orszulak, MD; Hartzell V. Schaff, MD; Charles J. Mullany, MB, MS

From the Division of Cardiovascular Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minn.

Correspondence and reprint requests to Dr Charles J. Mullany, Mayo Clinic, 200 First St SW, Rochester, MN 55905. E-mail cmullany{at}mayo.edu

Background—Patients who have had previous CABG may subsequently develop significant mitral valve (MV) dysfunction that requires surgical intervention.

Methods and Results—We reviewed 80 consecutive patients who had had previous CABG and who underwent MV surgery between January 1972 and March 1997. Forty-seven (59%) had initial CABG elsewhere, and 5 had had previous CABG twice. The mean interval between the previous CABG and the MV surgery was 6.3 years (range, 4.4 months to -17 years). At least 15 patients had grade 1/4 to 2/4 mitral regurgitation at initial CABG. The study group included 59 men and 21 women, with a mean study group age of 65.5 years. Ninety-four percent had symptoms of congestive heart failure, 60% had angina, 96% were in NYHA class III to IV, and 37% had an ejection fraction (EF) <50%. Origin of the MV disease was ischemic in 33 patients, myxomatous in 19, combined ischemic and myxomatous in 16, rheumatic in 5, infective in 3, and unknown in 4. MV repair was performed in 46 patients (58%) and MV replacement (MVR) in 34. Concomitant repeat CABG was performed in 38 (48%) patients. In-hospital mortality was 7 of 80 (8.8%); no early death occurred among patients with myxomatous disease. EF <50% was the only significant predictor of early mortality. Overall 1-, 5-, and 10-year survival was 83.8%, 55.6%, and 34.4% respectively. Predictors of late cardiac death were preoperative NYHA class IV (P=0.0006), urgent or emergency operation (P<0.0001), use of intra-aortic balloon pump (P=0.002), and EF <50% (P=0.01). Seven patients had an additional reoperation: 4 received CABG, 2 MVR, and 2 MV repair.

Conclusions—Ischemic, myxomatous, rheumatic, or infective MV dysfunction may develop subsequently after CABG. MVR or MV repair after previous CABG is associated with an acceptably low operative risk and good relief of symptoms. Left ventricular function is strongly correlated with both hospital and late mortality. Surgery should be done before LV dysfunction develops.

Key Words: mitral valve • coronary disease • bypass • grafting