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(Circulation. 1999;100:1016-1030.)
© 1999 American Heart Association, Inc.


ACC/AHA Practice Guidelines

1999 Update: ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction: Executive Summary and Recommendations

A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction)

Committee Members; Thomas J. Ryan, MD, FACC, Chair; Elliott M. Antman, MD, FACC; Neil H. Brooks, MD, FAAFP; Robert M. Califf, MD, FACC; L. David Hillis, MD, FACC; Loren F. Hiratzka, MD, FACC; Elliot Rapaport, MD, FACC; Barbara Riegel, DNScFAAN; Richard O. Russell, MD, FACC; Earl E. Smith, III, MDFACEP; W. Douglas Weaver, MD, FACC; Task Force Members; Raymond J. Gibbons, MD, FACC, Chair; Joseph S. Alpert, MD, FACC; Kim A. Eagle, MD, FACC; Timothy J. Gardner, MD, FACC; Arthur Garson, Jr, MD, MPH, FACC; Gabriel Gregoratos, MD, FACC; Richard O. Russell, MD, FACC; Thomas J. Ryan, MD, FACC; Sidney C. Smith, Jr, MD, FACC


Key Words: AHA Scientific Statements • reperfusion • thrombolysis • myocardial infarction • angioplasty


*    Introduction
 
The American College of Cardiology/American Heart Association (ACC/AHA) Guidelines for the Management of Patients With Acute Myocardial Infarction have been reviewed over the past 2.5 years since their initial publication in the Journal of the American College of Cardiology (1996;28:1328–1428) to ensure their continued relevancy. The guidelines have been updated to include the most significant advances that have occurred in the management of patients with acute myocardial infarction (AMI) during that time frame. This update was developed to keep the guidelines current without republishing the entire document. This effort represents a new procedure of the ACC/AHA Task Force on Practice Guidelines. These guidelines will be reviewed and updated as necessary until it is deemed appropriate to revise and republish the entire document.

The guidelines, incorporating the update, are available on the Web sites of both the American College of Cardiology (www.acc.org) and the American Heart Association (www.americanheart.org). In the Web site version, deleted text is indicated by strikeout, and new/revised text is presented as double-underlined type. Reprints of the original document with the revised sections appended are available from both organizations (see information below).


*    Recommendations
 
The following is a listing of the recommendations made by the ACC/AHA Task Force on Practice Guidelines in the ACC/AHA Task Force Report "ACC/AHA Guidelines for the Management of Patients With Acute Myocardial Infarction." More detailed information regarding the evidence and the rationale for these recommendations can be found in the full text of the guidelines themselves, which appears in the November 1996 and September 1999 . . . [Full Text of this Article]

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[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
A. Desideri, P. M. Fioretti, L. Cortigiani, D. Gregori, C. Coletta, C. Vigna, F. Tota, R. Rambaldi, J. Bax, L. Celegon, et al.
Cost of strategies after myocardial infarction (COSTAMI): A multicentre, international, randomized trial for cost-effective discharge after uncomplicated myocardial infarction
Eur. Heart J., September 2, 2003; 24(18): 1630 - 1639.
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J CARDIOVASC PHARMACOL THERHome page
B. I. Jugdutt and V. Menon
Upregulation of Angiotensin II Type 2 Receptor and Limitation of Myocardial Stunning by Angiotensin II Type 1 Receptor Blockers during Reperfused Myocardial Infarction in the Rat
Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2003; 8(3): 217 - 226.
[Abstract] [PDF]


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NEJMHome page
C. Lenfant
Clinical Research to Clinical Practice -- Lost in Translation?
N. Engl. J. Med., August 28, 2003; 349(9): 868 - 874.
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NEJMHome page
S. Schulman
Care of Patients Receiving Long-Term Anticoagulant Therapy
N. Engl. J. Med., August 14, 2003; 349(7): 675 - 683.
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CirculationHome page
L. Wallentin, P. Goldstein, P.W. Armstrong, C.B. Granger, A.A.J. Adgey, H.R. Arntz, K. Bogaerts, T. Danays, B. Lindahl, M. Makijarvi, et al.
Efficacy and Safety of Tenecteplase in Combination With the Low-Molecular-Weight Heparin Enoxaparin or Unfractionated Heparin in the Prehospital Setting: The Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 PLUS Randomized Trial in Acute Myocardial Infarction
Circulation, July 15, 2003; 108(2): 135 - 142.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
V. Menon
Cardiogenic shock: have we really found the magic potion?
Eur. Heart J., July 2, 2003; 24(14): 1279 - 1281.
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Eur Heart JHome page
E. Buiatti, A. Barchielli, N. Marchionni, D. Balzi, N. Carrabba, S. Valente, I. Olivotto, C. Landini, M. Filice, M. Torri, et al.
Determinants of treatment strategies and survival in acute myocardial infarction: a population-based study in the Florence district, Italy: Results of the acute myocardial infarction Florence registry (AMI-Florence),
Eur. Heart J., July 1, 2003; 24(13): 1195 - 1203.
[Abstract] [Full Text] [PDF]


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JAMAHome page
B. M. Psaty, T. Lumley, C. D. Furberg, G. Schellenbaum, M. Pahor, M. H. Alderman, and N. S. Weiss
Health Outcomes Associated With Various Antihypertensive Therapies Used as First-Line Agents: A Network Meta-analysis
JAMA, May 21, 2003; 289(19): 2534 - 2544.
[Abstract] [Full Text] [PDF]


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J Am Coll CardiolHome page
J. A. Spertus, M. J. Radford, N. R. Every, E. F. Ellerbeck, E. D. Peterson, and H. M. Krumholz
Challenges and opportunities in quantifying the quality of care for acute myocardial infarction: Summary from the acute myocardial infarction working group of the American heart association/American college of cardiology first scientific forum on quality of care and outcomes research in cardiovascular disease and stroke
J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1653 - 1663.
[Full Text] [PDF]


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American Journal of Medical QualityHome page
S. Dulworth
Commentary: Exploiting the Overlap: Using Utilization Management to Reduce Medical Malpractice
American Journal of Medical Quality, May 1, 2003; 18(3): 128 - 132.
[Abstract] [PDF]


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CirculationHome page
J. A. Spertus, M. J. Radford, N. R. Every, E. F. Ellerbeck, E. D. Peterson, and H. M. Krumholz
Challenges and Opportunities in Quantifying the Quality of Care for Acute Myocardial Infarction: Summary From the Acute Myocardial Infarction Working Group of the American Heart Association/American College of Cardiology First Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke
Circulation, April 1, 2003; 107(12): 1681 - 1691.
[Full Text] [PDF]


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NEJMHome page
P. J. Zimetbaum and M. E. Josephson
Use of the Electrocardiogram in Acute Myocardial Infarction
N. Engl. J. Med., March 6, 2003; 348(10): 933 - 940.
[Full Text] [PDF]


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CMAJHome page
K. Tu, M. M. Mamdani, R. M. Jacka, N. J. Forde, D. M. Rothwell, and J. V. Tu
The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on ramipril prescribing in Ontario
Can. Med. Assoc. J., March 4, 2003; 168(5): 553 - 557.
[Abstract] [Full Text] [PDF]


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CirculationHome page
S. S. Rathore, K. P. Weinfurt, C. P. Gross, and H. M. Krumholz
Validity of a Simple ST-Elevation Acute Myocardial Infarction Risk Index: Are Randomized Trial Prognostic Estimates Generalizable to Elderly Patients?
Circulation, February 18, 2003; 107(6): 811 - 816.
[Abstract] [Full Text] [PDF]


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ANN INTERN MEDHome page
E. Vittinghoff, M. G. Shlipak, P. D. Varosy, C. D. Furberg, C. C. Ireland, S. S. Khan, R. Blumenthal, E. Barrett-Connor, S. Hulley, and for the Heart and Estrogen/progestin Replacement S
Risk Factors and Secondary Prevention in Women with Heart Disease: The Heart and Estrogen/progestin Replacement Study
Ann Intern Med, January 21, 2003; 138(2): 81 - 89.
[Abstract] [Full Text] [PDF]


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HeartHome page
F Burzotta, M Hamon, R Sabatier, F Prati, A Boccanelli, and G Grollier
Large intracoronary thrombi with good TIMI flow during acute myocardial infarction: four cases of successful aggressive medical management in patients without angiographically detectable coronary atherosclerosis
Heart, December 1, 2002; 88(5): e6 - 6.
[Abstract] [Full Text] [PDF]


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HeartHome page
V. Menon and J. S Hochman
MANAGEMENT OF CARDIOGENIC SHOCK COMPLICATING ACUTE MYOCARDIAL INFARCTION
Heart, December 1, 2002; 88(5): 531 - 537.
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Postgrad. Med. J.Home page
P J Sheridan and D C Crossman
Critical review of unstable angina and non-ST elevation myocardial infarction
Postgrad. Med. J., December 1, 2002; 78(926): 717 - 726.
[Abstract] [Full Text] [PDF]


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Arch Intern MedHome page
B. M. Psaty, T. A. Manolio, N. L. Smith, S. R. Heckbert, J. S. Gottdiener, G. L. Burke, J. Weissfeld, P. Enright, T. Lumley, N. Powe, et al.
Time Trends in High Blood Pressure Control and the Use of Antihypertensive Medications in Older Adults: The Cardiovascular Health Study
Arch Intern Med, November 11, 2002; 162(20): 2325 - 2332.
[Abstract] [Full Text] [PDF]


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Br J AnaesthHome page
P.-G. Chassot, A. Delabays, and D. R. Spahn
Preoperative evaluation of patients with, or at risk of, coronary artery disease undergoing non-cardiac surgery
Br. J. Anaesth., November 1, 2002; 89(5): 747 - 759.
[Abstract] [Full Text] [PDF]


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CirculationHome page
D. Mukherjee, P. Lingam, S. Chetcuti, P. M. Grossman, M. Moscucci, A. E. Luciano, and K. A. Eagle
Missed Opportunities to Treat Atherosclerosis in Patients Undergoing Peripheral Vascular Interventions: Insights From the University of Michigan Peripheral Vascular Disease Quality Improvement Initiative (PVD-QI2)
Circulation, October 8, 2002; 106(15): 1909 - 1912.
[Abstract] [Full Text] [PDF]


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Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
W. S. Aronow
Guest Editorial: What Is the Appropriate Treatment of Hypertension in Elders?
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2002; 57(8): M483 - 486.
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ANN INTERN MEDHome page
H. P. Selker, J. R. Beshansky, J. L. Griffith, and for the TPI Trial Investigators*
Use of the Electrocardiograph-Based Thrombolytic Predictive Instrument To Assist Thrombolytic and Reperfusion Therapy for Acute Myocardial Infarction: A Multicenter, Randomized, Controlled, Clinical Effectiveness Trial
Ann Intern Med, July 16, 2002; 137(2): 87 - 95.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
R. Sicari, P. Landi, E. Picano, S. Pirelli, G. Chiaranda, M. Previtali, G. Seveso, N. Gandolfo, F. Margaria, O. Magaia, et al.
Exercise-electrocardiography and/or pharmacological stress echocardiography for non-invasive risk stratification early after uncomplicated myocardial infarction. A prospective international large scale multicentre study
Eur. Heart J., July 1, 2002; 23(13): 1030 - 1037.
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ANGIOLOGYHome page
K. Kanamasa, T. Hayashi, A. Kimura, A. Ikeda, K. Ishikawa, and secondary prevention group
Long-term, Continuous Treatment with Both Oral and Transdermal Nitrates Increases Cardiac Events in Healed Myocardial Infarction Patients
Angiology, July 1, 2002; 53(4): 399 - 408.
[Abstract] [PDF]


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J Intensive Care MedHome page
N. J. Goswami, J. M. Moody Jr, and S. R. Bailey
Percutaneous Mechanical Reperfusion During Acute Myocardial Infarction
J Intensive Care Med, July 1, 2002; 17(4): 162 - 173.
[Abstract] [PDF]


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J Intensive Care MedHome page
S. Allaqaband and T. K. Bajwa
"Time Is Muscle" Only in Experienced Hands and High-Volume Centers
J Intensive Care Med, July 1, 2002; 17(4): 199 - 201.
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CirculationHome page
F. Van de Werf and D. S. Baim
Reperfusion for ST-Segment Elevation Myocardial Infarction: An Overview of Current Treatment Options
Circulation, June 18, 2002; 105(24): 2813 - 2816.
[Full Text] [PDF]


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CirculationHome page
M. A. Pfeffer and J. J.V. McMurray
Myocardial Infarct: No One Size Fits All
Circulation, June 4, 2002; 105(22): 2577 - 2579.
[Full Text] [PDF]


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Eur Heart JHome page
F. van de Werf
ASSENT-3: implications for future trial design and clinical practice
Eur. Heart J., June 2, 2002; 23(12): 911 - 912.
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Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S. Ghosh, V. Ziesmer, and W. S. Aronow
Underutilization of Aspirin, Beta Blockers, Angiotensin-Converting Enzyme Inhibitors, and Lipid-Lowering Drugs and Overutilization of Calcium Channel Blockers in Older Persons With Coronary Artery Disease in an Academic Nursing Home
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2002; 57(6): M398 - 400.
[Abstract] [Full Text]


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JAMAHome page
C. P. Cannon
Primary Percutaneous Coronary Intervention for All?
JAMA, April 17, 2002; 287(15): 1987 - 1989.
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JNMHome page
R. Sciagra, S. Sestini, L. Bolognese, G. Cerisano, P. Buonamici, and A. Pupi
Comparison of Dobutamine Echocardiography and 99mTc-Sestamibi Tomography for Prediction of Left Ventricular Ejection Fraction Outcome After Acute Myocardial Infarction Treated with Successful Primary Coronary Angioplasty
J. Nucl. Med., January 1, 2002; 43(1): 8 - 14.
[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
F. Van de Werf, H.V. Barron, P.W. Armstrong, C.B. Granger, S. Berioli, G. Barbash, K. Pehrsson, F.W.A. Verheugt, J. Meyer, A. Betriu, et al.
Incidence and predictors of bleeding events after fibrinolytic therapy with fibrin-specific agents. A comparison of TNK-tPA and rt-PA
Eur. Heart J., December 2, 2001; 22(24): 2253 - 2261.
[Abstract] [PDF]


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ANN INTERN MEDHome page
E. M. Ohman and E. Peterson
Implications and Challenges Using Practice Guidelines for Chronic Angina
Ann Intern Med, October 2, 2001; 135(7): 527 - 529.
[Full Text] [PDF]