| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 1999;100:230-235.)
© 1999 American Heart Association, Inc.
Clinical Investigation and Reports |
Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein
From the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (P.M.R., M.A.P., F.S., E.B.), and the Children's Hospital Medical Center (N.R.), Boston, Mass.
Correspondence to Dr Paul M. Ridker, Cardiovascular Diseases, Brigham and Womens' Hospital, 75 Francis St, Boston, MA 02115. E-mail pridker{at}rics.bwh.harvard.edu
Background—Elevated plasma concentrations of C-reactive protein (CRP) are associated with increased cardiovascular risk. We evaluated whether long-term therapy with pravastatin, an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter.
Methods and Results—CRP levels were measured at baseline and at 5 years in 472 randomly selected participants in the Cholesterol and Recurrent Events (CARE) trial who remained free of recurrent coronary events during follow-up. Overall, CRP levels at baseline and at 5 years were highly correlated (r=0.60, P<0.001). However, among those allocated to placebo, median CRP levels and the mean change in CRP tended to increase over time (median change, +4.2%; P=0.2 and mean change, +0.07 mg/dL; P=0.04). By contrast, median CRP levels and the mean change in CRP decreased over time among those allocated to pravastatin (median change, -17.4%; P=0.004 and mean change, -0.07 mg/dL; P=0.002). Thus, statistically significant differences were observed at 5 years between the pravastatin and placebo groups in terms of median CRP levels (difference, -21.6%; P=0.007), mean CRP levels (difference, -37.8%; P=0.002), and absolute mean change in CRP (difference, -0.137 mg/dL; P=0.003). These effects persisted in analyses stratified by age, body mass index, smoking status, blood pressure, and baseline lipid levels. Attempts to relate the magnitude of change in CRP to the magnitude of change in lipids in both the pravastatin and placebo groups did not reveal any obvious relationships.
Conclusions—Among survivors of myocardial infarction on standard therapy plus placebo, CRP levels tended to increase over 5 years of follow-up. In contrast, randomization to pravastatin resulted in significant reductions in this inflammatory marker that were not related to the magnitude of lipid alterations observed. Thus, these data further support the potential for nonlipid effects of this agent.
Key Words: myocardial infarction • proteins • pravastatin • atherosclerosis
This article has been cited by other articles:
 |
|
 |
|
  H. Hara, M. Nakamura, I. Yokouchi, K. Kimura, N. Nemoto, S. Ito, T. Ono, H. Itaya, M. Shiba, M. Wada, et al. Aggressive statin therapy in multicenter and effectiveness for the reduction of intra-myocardial damage caused by non-ST elevation acute coronary syndrome: AMERICA study Therapeutic Advances in Cardiovascular Disease, October 1, 2009; 3(5): 357 - 365. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Schiele, N. Meneveau, M. F. Seronde, R. Chopard, V. Descotes-Genon, J. Dutheil, J.-P. Bassand, and on behalf on the 'Reseau de Cardiologie de Franche C-reactive protein improves risk prediction in patients with acute coronary syndromes Eur. Heart J., July 4, 2009; (2009) ehp273v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cattaneo Letter by Cattaneo Regarding Article, "Incomplete Inhibition of Thromboxane Biosynthesis by Acetylsalicylic Acid: Determinants and Effect on Cardiovascular Risk" Circulation, June 23, 2009; 119(24): e594 - e594. [Full Text] [PDF]
|
|
|
|
 |
|
 P. M Ridker The JUPITER Trial: Results, Controversies, and Implications for Prevention Circ Cardiovasc Qual Outcomes, May 1, 2009; 2(3): 279 - 285. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Libby Molecular and cellular mechanisms of the thrombotic complications of atherosclerosis J. Lipid Res., April 1, 2009; 50(Supplement): S352 - S357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shemesh, K. G. Rowley, A. J. Jenkins, J. D. Best, and K. O'Dea C-Reactive Protein Concentrations Are Very High and More Stable over Time Than the Traditional Vascular Risk Factors Total Cholesterol and Systolic Blood Pressure in an Australian Aboriginal Cohort Clin. Chem., February 1, 2009; 55(2): 336 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mora, K. Musunuru, and R. S. Blumenthal The Clinical Utility of High-Sensitivity C-Reactive Protein in Cardiovascular Disease and the Potential Implication of JUPITER on Current Practice Guidelines Clin. Chem., February 1, 2009; 55(2): 219 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Glynn, J. G. MacFadyen, and P. M Ridker Tracking of High-Sensitivity C-Reactive Protein after an Initially Elevated Concentration: The JUPITER Study Clin. Chem., February 1, 2009; 55(2): 305 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M Ridker C-Reactive Protein: Eighty Years from Discovery to Emergence as a Major Risk Marker for Cardiovascular Disease Clin. Chem., February 1, 2009; 55(2): 209 - 215. [Full Text] [PDF]
|
|
|
|
|
|
A. D. Hingorani, T. Shah, J. P. Casas, S. E. Humphries, and P. J. Talmud C-Reactive Protein and Coronary Heart Disease: Predictive Test or Therapeutic Target? Clin. Chem., February 1, 2009; 55(2): 239 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Howren, D. M. Lamkin, and J. Suls Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis Psychosom Med, February 1, 2009; 71(2): 171 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. SHISHEHBOR and S. L. HAZEN JUPITER to Earth: A statin helps people with normal LDL-C and high hs-CRP, but what does it mean? Cleveland Clinic Journal of Medicine, January 1, 2009; 76(1): 37 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gottsater, D. Flondell-Site, T. Kolbel, and B. Lindblad Associations Between Statin Treatment and Markers of Inflammation, Vasoconstriction, and Coagulation in Patients With Abdominal Aortic Aneurysm Vascular and Endovascular Surgery, January 1, 2009; 42(6): 567 - 573. [Abstract] [PDF]
|
|
|
|
|
|
E. S. Spatz, M. E. Canavan, and M. M. Desai From Here to JUPITER: Identifying New Patients for Statin Therapy Using Data From the 1999-2004 National Health and Nutrition Examination Survey Circ Cardiovasc Qual Outcomes, January 1, 2009; 2(1): 41 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Mannacio, D. Iorio, V. De Amicis, F. Di Lello, and F. Musumeci Effect of rosuvastatin pretreatment on myocardial damage after coronary surgery: a randomized trial. J. Thorac. Cardiovasc. Surg., December 1, 2008; 136(6): 1541 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M Ridker, E. Danielson, F. A.H. Fonseca, J. Genest, A. M. Gotto Jr., J. J.P. Kastelein, W. Koenig, P. Libby, A. J. Lorenzatti, J. G. MacFadyen, et al. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein N. Engl. J. Med., November 20, 2008; 359(21): 2195 - 2207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W.F. Wilson, M. Pencina, P. Jacques, J. Selhub, R. D'Agostino Sr, and C. J. O'Donnell C-Reactive Protein and Reclassification of Cardiovascular Risk in the Framingham Heart Study Circ Cardiovasc Qual Outcomes, November 1, 2008; 1(2): 92 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sanchez-Quinones, F. Marin, V. Roldan, and G.Y.H. Lip The impact of statin use on atrial fibrillation QJM, November 1, 2008; 101(11): 845 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Isma, J. Barani, I. Mattiasson, B. Lindblad, and A. Gottsater Lipid-Lowering Therapy is Related to Inflammatory Markers and 3-Year Mortality in Patients With Critical Limb Ischemia Angiology, October 1, 2008; 59(5): 542 - 548. [Abstract] [PDF]
|
|
|
|
|
|
A. L. Hogh, J. Joensen, J. S. Lindholt, M. R. Jacobsen, and L. Ostergaard C-Reactive Protein Predicts Future Arterial and Cardiovascular Events in Patients With Symptomatic Peripheral Arterial Disease Vascular and Endovascular Surgery, August 1, 2008; 42(4): 341 - 347. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Nabi, A. Singh-Manoux, M. Shipley, D. Gimeno, M. G. Marmot, and M. Kivimaki Do Psychological Factors Affect Inflammation and Incident Coronary Heart Disease: The Whitehall II Study Arterioscler Thromb Vasc Biol, July 1, 2008; 28(7): 1398 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodriguez-Yanez, J. Agulla, R. Rodriguez-Gonzalez, T. Sobrino, and J. Castillo Review: Statins and stroke Therapeutic Advances in Cardiovascular Disease, June 1, 2008; 2(3): 157 - 166. [Abstract] [PDF]
|
|
|
|
|
|
E. Debing, E. Peeters, C. Demanet, M. De Waele, and P. Van den Brande Markers of Inflammation in Patients With Symptomatic and Asymptomatic Carotid Artery Stenosis: A Case-Control Study Vascular and Endovascular Surgery, May 1, 2008; 42(2): 122 - 127. [Abstract] [PDF]
|
|
|
|
 |
|
 J. A. Falk, S. Kadiev, G. J. Criner, S. M. Scharf, O. A. Minai, and P. Diaz Cardiac Disease in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, May 1, 2008; 5(4): 543 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Sutton, D. R. Crosslin, S. H. Shah, S. C. Nelson, A. Bassil, A. B. Hale, C. Haynes, P. J. Goldschmidt-Clermont, J. M. Vance, D. Seo, et al. Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets Hum. Mol. Genet., May 1, 2008; 17(9): 1318 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Z. LaCroix, S. L. Gray, A. Aragaki, B. B. Cochrane, A. B. Newman, C. L. Kooperberg, H. Black, J. D. Curb, P. Greenland, and N. F. Woods Statin Use and Incident Frailty in Women Aged 65 Years or Older: Prospective Findings From the Women's Health Initiative Observational Study J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2008; 63(4): 369 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Gao, L. Linhartova, A. McD. Johnston, and D. R. Thickett Statins and sepsis Br. J. Anaesth., March 1, 2008; 100(3): 288 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Conen, B M Everett, R J Glynn, and P M Ridker Effect of valsartan compared with valsartan/hydrochlorothiazide on plasma levels of cellular adhesion molecules: the Val-MARC trial Heart, March 1, 2008; 94(3): e13 - e13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dandona Effects of Antidiabetic and Antihyperlipidemic Agents on C-Reactive Protein Mayo Clin. Proc., March 1, 2008; 83(3): 333 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. S. Packard and P. Libby Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction Clin. Chem., January 1, 2008; 54(1): 24 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Catov, L. M. Bodnar, R. B. Ness, S. J. Barron, and J. M. Roberts Inflammation and Dyslipidemia Related to Risk of Spontaneous Preterm Birth Am. J. Epidemiol., December 1, 2007; 166(11): 1312 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Szwast, H. C. Hendrie, K. A. Lane, S. Gao, S. E. Taylor, F. Unverzagt, J. Murrell, M. Deeg, A. Ogunniyi, M. R. Farlow, et al. Association of statin use with cognitive decline in elderly African Americans Neurology, November 6, 2007; 69(19): 1873 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Gortney and R. M. Sanders Impact of C-reactive protein on treatment of patients with cardiovascular disease Am. J. Health Syst. Pharm., October 1, 2007; 64(19): 2009 - 2016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Boekhoorn, J. R. Vingerling, J. C. M. Witteman, A. Hofman, and P. T. V. M. de Jong C-reactive Protein Level and Risk of Aging Macula Disorder: The Rotterdam Study Arch Ophthalmol, October 1, 2007; 125(10): 1396 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tahara, H. Kai, H. Nakaura, M. Mizoguchi, M. Ishibashi, H. Kaida, K. Baba, N. Hayabuchi, and T. Imaizumi The prevalence of inflammation in carotid atherosclerosis: analysis with fluorodeoxyglucose positron emission tomography Eur. Heart J., September 2, 2007; 28(18): 2243 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Anan, T. Masaki, Y. Umeno, T. Iwao, H. Yonemochi, N. Eshima, T. Saikawa, and H. Yoshimatsu Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients Eur. J. Endocrinol., September 1, 2007; 157(3): 311 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hatunic, F. Finucane, N. Burns, D. Gasparro, and J. J Nolan Vascular inflammatory markers in early-onset obese and type 2 diabetes subjects before and after three months' aerobic exercise training Diabetes and Vascular Disease Research, September 1, 2007; 4(3): 231 - 234. [Abstract] [PDF]
|
|
|
|
 |
|
 K. M. Maki-Petaja, A. D. Booth, F. C. Hall, S. M.L. Wallace, J. Brown, C. M. McEniery, and I. B. Wilkinson Ezetimibe and Simvastatin Reduce Inflammation, Disease Activity, and Aortic Stiffness and Improve Endothelial Function in Rheumatoid Arthritis J. Am. Coll. Cardiol., August 28, 2007; 50(9): 852 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Ridker C-Reactive Protein and the Prediction of Cardiovascular Events Among Those at Intermediate Risk: Moving an Inflammatory Hypothesis Toward Consensus J. Am. Coll. Cardiol., May 29, 2007; 49(21): 2129 - 2138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
NACB WRITING GROUP MEMBERS, D. A. Morrow, C. P. Cannon, R. L. Jesse, L. K. Newby, J. Ravkilde, A. B. Storrow, A. H.B. Wu, and R. H. Christenson National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes Circulation, April 3, 2007; 115(13): e356 - e375. [Full Text] [PDF]
|
|
|
|
|
|
H. Oren, A. R. Erbay, M. Balci, and S. Cehreli Role of Novel Biomarkers of Inflammation in Patients With Stable Coronary Heart Disease Angiology, April 1, 2007; 58(2): 148 - 155. [Abstract] [PDF]
|
|
|
|
 |
|
 S. C. Fagan, H. F. Elewa, and D. J. Rychly Statin Therapy for Secondary Stroke Prevention: Evidence Catches Up to Practice Journal of Pharmacy Practice, April 1, 2007; 20(2): 117 - 122. [Abstract] [PDF]
|
|
|
|
|
|
NACB WRITING GROUP MEMBERS, D. A. Morrow, C. P. Cannon, R. L. Jesse, L. K. Newby, J. Ravkilde, A. B. Storrow, A. H.B. Wu, R. H. Christenson, NACB COMMITTEE MEMBERS, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes Clin. Chem., April 1, 2007; 53(4): 552 - 574. [Full Text] [PDF]
|
|
|
|
|
|
K. K. Khush, D. D. Waters, V. Bittner, P. C. Deedwania, J. J.P. Kastelein, S. J. Lewis, and N. K. Wenger Effect of High-Dose Atorvastatin on Hospitalizations for Heart Failure: Subgroup Analysis of the Treating to New Targets (TNT) Study Circulation, February 6, 2007; 115(5): 576 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Schett, S. Kiechl, S. Weger, A. Pederiva, A. Mayr, M. Petrangeli, F. Oberhollenzer, R. Lorenzini, K. Redlich, R. Axmann, et al. High-Sensitivity C-Reactive Protein and Risk of Nontraumatic Fractures in the Bruneck Study Arch Intern Med, December 11, 2006; 166(22): 2495 - 2501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Carty, P. Heagerty, K. Nakayama, E. C. McClung, J. Lewis, D. Lum, E. Boespflug, C. McCloud-Gehring, B. R. Soleimani, J. Ranchalis, et al. Inflammatory Response After Influenza Vaccination in Men With and Without Carotid Artery Disease Arterioscler Thromb Vasc Biol, December 1, 2006; 26(12): 2738 - 2744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schmidt, H. Schmidt, M. Pichler, C. Enzinger, K. Petrovic, K. Niederkorn, S. Horner, S. Ropele, N. Watzinger, M. Schumacher, et al. C-Reactive Protein, Carotid Atherosclerosis, and Cerebral Small-Vessel Disease: Results of the Austrian Stroke Prevention Study Stroke, December 1, 2006; 37(12): 2910 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tahara, H. Kai, M. Ishibashi, H. Nakaura, H. Kaida, K. Baba, N. Hayabuchi, and T. Imaizumi Simvastatin Attenuates Plaque Inflammation: Evaluation by Fluorodeoxyglucose Positron Emission Tomography J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1825 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Libby and P. M. Ridker Inflammation and Atherothrombosis: From Population Biology and Bench Research to Clinical Practice J. Am. Coll. Cardiol., October 27, 2006; 48(9_Suppl_A): A33 - A46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Juonala, J. S.A. Viikari, T. Ronnemaa, L. Taittonen, J. Marniemi, and O. T. Raitakari Childhood C-Reactive Protein in Predicting CRP and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study Arterioscler Thromb Vasc Biol, August 1, 2006; 26(8): 1883 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A.N. Verhoeven, F. L. Moll, J. A.F. Koekkoek, A. C. van der Wal, D. P.V. de Kleijn, J. P. P.M. de Vries, J. H. Verheijen, E. Velema, E. Busser, A. Schoneveld, et al. Statin Treatment Is Not Associated With Consistent Alterations in Inflammatory Status of Carotid Atherosclerotic Plaques: A Retrospective Study in 378 Patients Undergoing Carotid Endarterectomy Stroke, August 1, 2006; 37(8): 2054 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Albert and P. M Ridker C-Reactive Protein as a Risk Predictor: Do Race/Ethnicity and Gender Make a Difference? Circulation, August 1, 2006; 114(5): e67 - e74. [Full Text] [PDF]
|
|
|
|
|
|
G. Onder, S. Volpato, R. Liperoti, C. D'Arco, C. Maraldi, R. Fellin, R. Bernabei, F. Landi, and on Behalf of the GIFA Investigators Total serum cholesterol and recovery from disability among hospitalized older adults. J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2006; 61(7): 736 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Groschel, U. Ernemann, J. B. Schulz, T. Nagele, C. Terborg, and A. Kastrup Statin Therapy at Carotid Angioplasty and Stent Placement: Effect on Procedure-related Stroke, Myocardial Infarction, and Death. Radiology, July 1, 2006; 240(1): 145 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Scirica, D. A. Morrow, S. Verma, S. Devaraj, I. Jialal, B. M. Scirica, D. A. Morrow, S. Verma, S. Devaraj, and I. Jialal The Verdict Is Still Out Circulation, May 2, 2006; 113(17): 2128 - 2151. [Full Text] [PDF]
|
|
|
|
|
|
S. Tsimikas, J. T. Willerson, and P. M. Ridker C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C19 - C31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bollerslev, T. Ueland, A. P Jorgensen, K. J Fougner, R. Wergeland, T. Schreiner, and P. Burman Positive effects of a physiological dose of GH on markers of atherogenesis: a placebo-controlled study in patients with adult-onset GH deficiency. Eur. J. Endocrinol., April 1, 2006; 154(4): 537 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-K. Kuo, J. F. Bean, C.-J. Yen, and S. G. Leveille Linking C-Reactive Protein to Late-Life Disability in the National Health and Nutrition Examination Survey (NHANES) 1999-2002. J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2006; 61(4): 380 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kathiresan, M. G. Larson, R. S. Vasan, C.-Y. Guo, P. Gona, J. F. Keaney Jr, P. W.F. Wilson, C. Newton-Cheh, S. L. Musone, A. L. Camargo, et al. Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level Circulation, March 21, 2006; 113(11): 1415 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Iwakura, H. Ito, S. Kawano, A. Okamura, T. Kurotobi, M. Date, K. Inoue, and K. Fujii Chronic pre-treatment of statins is associated with the reduction of the no-reflow phenomenon in the patients with reperfused acute myocardial infarction Eur. Heart J., March 1, 2006; 27(5): 534 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Gunter, R. Stolzenberg-Solomon, A. J. Cross, M. F. Leitzmann, S. Weinstein, R. J. Wood, J. Virtamo, P. R. Taylor, D. Albanes, and R. Sinha A Prospective Study of Serum C-Reactive Protein and Colorectal Cancer Risk in Men Cancer Res., February 15, 2006; 66(4): 2483 - 2487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Eldrup, H. Sillesen, E. Prescott, and B. G. Nordestgaard Ankle brachial index, C-reactive protein, and central augmentation index to identify individuals with severe atherosclerosis Eur. Heart J., February 1, 2006; 27(3): 316 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Boos, R. A. Anderson, and G. Y.H. Lip Is atrial fibrillation an inflammatory disorder? Eur. Heart J., January 2, 2006; 27(2): 136 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Li, C.-H. Fang, H.-Y. Qian, and W.-L. Hu Time Course of Rapid C-Reactive Protein Reduction by Pravastatin in Patients with Stable Angina Angiology, January 1, 2006; 57(1): 1 - 7. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Ginsburg, M. P. Donahue, and L. K. Newby Prospects for Personalized Cardiovascular Medicine: The Impact of Genomics J. Am. Coll. Cardiol., November 1, 2005; 46(9): 1615 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Il'yasova, L. H. Colbert, T. B. Harris, A. B. Newman, D. C. Bauer, S. Satterfield, and S. B. Kritchevsky Circulating Levels of Inflammatory Markers and Cancer Risk in the Health Aging and Body Composition Cohort Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2413 - 2418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Finkelhor, G. Cater, A. Qureshi, D. Einstadter, M. T. Hecker, and G. Bosich Seasonal Diagnosis of Echocardiographically Demonstrated Endocarditis Chest, October 1, 2005; 128(4): 2588 - 2592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sun, T. Koike, T. Ichikawa, K. Hatakeyama, M. Shiomi, B. Zhang, S. Kitajima, M. Morimoto, T. Watanabe, Y. Asada, et al. C-Reactive Protein in Atherosclerotic Lesions: Its Origin and Pathophysiological Significance Am. J. Pathol., October 1, 2005; 167(4): 1139 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Scranton, M. Young, E. Lawler, D. Solomon, D. Gagnon, and J. M. Gaziano Statin Use and Fracture Risk: Study of a US Veterans Population Arch Intern Med, September 26, 2005; 165(17): 2007 - 2012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Calabro, D. W. Chang, J. T. Willerson, and E. T.H. Yeh Release of C-Reactive Protein in Response to Inflammatory Cytokines by Human Adipocytes: Linking Obesity to Vascular Inflammation J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1112 - 1113. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Erkkila, M. Jauhiainen, K. Laitinen, K. Haasio, T. Tiirola, P. Saikku, and M. Leinonen Effect of Simvastatin, an Established Lipid-Lowering Drug, on Pulmonary Chlamydia pneumoniae Infection in Mice Antimicrob. Agents Chemother., September 1, 2005; 49(9): 3959 - 3962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Li and C.-H. Fang Effects of 4 Weeks of Atorvastatin Administration on the Antiinflammatory Cytokine Interleukin-10 in Patients with Unstable Angina Clin. Chem., September 1, 2005; 51(9): 1735 - 1738. [Full Text] [PDF]
|
|
|
|
|
|
L. G. Best, Y. Zhang, E. T. Lee, J.-L. Yeh, L. Cowan, V. Palmieri, M. Roman, R. B. Devereux, R. R. Fabsitz, R. P. Tracy, et al. C-Reactive Protein as a Predictor of Cardiovascular Risk in a Population With a High Prevalence of Diabetes: The Strong Heart Study Circulation, August 30, 2005; 112(9): 1289 - 1295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.T. Ong The statin studies: from targeting hypercholesterolaemia to targeting the high-risk patient QJM, August 1, 2005; 98(8): 599 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lorenz, C. Junger, K. Seidl, A. Gitt, S. Schneider, R. Schiele, H. Wienbergen, R. Winkler, M. Gottwik, W. Delius, et al. Do statins influence the prognostic impact of non-sustained ventricular tachycardia after ST-elevation myocardial infarction? Eur. Heart J., June 1, 2005; 26(11): 1078 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Ridker, D. A. Morrow, L. M. Rose, N. Rifai, C. P. Cannon, and E. Braunwald Relative Efficacy of Atorvastatin 80 mg and Pravastatin 40 mg in Achieving the Dual Goals of Low-Density Lipoprotein Cholesterol <70 mg/dl and C-Reactive Protein <2 mg/l: An Analysis of the PROVE-IT TIMI-22 Trial J. Am. Coll. Cardiol., May 17, 2005; 45(10): 1644 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Li, T. Asagami, H. Matsushita, K.-H. Lee, and P. S. Tsao Rosuvastatin Attenuates Monocyte-Endothelial Cell Interactions and Vascular Free Radical Production in Hypercholesterolemic Mice J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 557 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A.H. Stewart, H. D. White, A. C. Kirby, S. R. Heritier, R. J. Simes, P. J. Nestel, M. J. West, D. M. Colquhoun, A. M. Tonkin, and for the Long-Term Intervention With Pravastatin in White Blood Cell Count Predicts Reduction in Coronary Heart Disease Mortality With Pravastatin Circulation, April 12, 2005; 111(14): 1756 - 1762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Stuveling, S. J. L. Bakker, H. L. Hillege, P. E. de Jong, R. O. B. Gans, and D. de Zeeuw Biochemical risk markers: a novel area for better prediction of renal risk? Nephrol. Dial. Transplant., March 1, 2005; 20(3): 497 - 508. [Full Text] [PDF]
|
|
|
|
|
|
A. Yonemura, Y. Momiyama, Z. A. Fayad, M. Ayaori, R. Ohmori, K. Higashi, T. Kihara, S. Sawada, N. Iwamoto, M. Ogura, et al. Effect of lipid-lowering therapy with atorvastatin on atherosclerotic aortic plaques detected by noninvasive magnetic resonance imaging J. Am. Coll. Cardiol., March 1, 2005; 45(5): 733 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gola, S. Bonadonna, M. Doga, and A. Giustina Growth Hormone and Cardiovascular Risk Factors J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1864 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sironi, E. Gianazza, P. Gelosa, U. Guerrini, E. Nobili, A. Gianella, B. Cremonesi, R. Paoletti, and E. Tremoli Rosuvastatin, but not Simvastatin, Provides End-Organ Protection in Stroke-Prone Rats by Antiinflammatory Effects Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): 598 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Campese, M. K. Nadim, and M. Epstein Are 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors Renoprotective? J. Am. Soc. Nephrol., March 1, 2005; 16(3_suppl_1): S11 - S17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schnabel, H. J. Rupprecht, K. J. Lackner, E. Lubos, C. Bickel, J. Meyer, T. Munzel, F. Cambien, L. Tiret, S. Blankenberg, et al. Analysis of N-terminal-pro-brain natriuretic peptide and C-reactive protein for risk stratification in stable and unstable coronary artery disease: results from the AtheroGene study Eur. Heart J., February 1, 2005; 26(3): 241 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bogaty, J. M. Brophy, L. Boyer, S. Simard, L. Joseph, F. Bertrand, and G. R. Dagenais Fluctuating Inflammatory Markers in Patients With Stable Ischemic Heart Disease Arch Intern Med, January 24, 2005; 165(2): 221 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M Ridker, C. P. Cannon, D. Morrow, N. Rifai, L. M. Rose, C. H. McCabe, M. A. Pfeffer, E. Braunwald, and the Pravastatin or Atorvastatin Evaluation and Inf C-Reactive Protein Levels and Outcomes after Statin Therapy N. Engl. J. Med., January 6, 2005; 352(1): 20 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Choi, K. W. Lee, S. G. Kim, N. H. Kim, C. G. Park, H. S. Seo, D. J. Oh, D. S. Choi, and S. H. Baik Inflammation, Insulin Resistance, and Glucose Intolerance in Acute Myocardial Infarction Patients without a Previous Diagnosis of Diabetes Mellitus J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 175 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Smith Jr, J. L. Anderson, R. O. Cannon III, Y. Y. Fadl, W. Koenig, P. Libby, S. E. Lipshultz, G. A. Mensah, P. M Ridker, and R. Rosenson CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: Report From the Clinical Practice Discussion Group Circulation, December 21, 2004; 110(25): e550 - e553. [Full Text] [PDF]
|
|
|
|
 |
|
 S Van Doornum, G McColl, and I P Wicks Atorvastatin reduces arterial stiffness in patients with rheumatoid arthritis Ann Rheum Dis, December 1, 2004; 63(12): 1571 - 1575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pleiner, G. Schaller, F. Mittermayer, S. Zorn, C. Marsik, S. Polterauer, S. Kapiotis, and M. Wolzt Simvastatin Prevents Vascular Hyporeactivity During Inflammation Circulation, November 23, 2004; 110(21): 3349 - 3354. [Abstract] [Full Text] [PDF]
|
|