(Circulation. 1999;100:2244.)
© 1999 American Heart Association, Inc.
Clinical Investigation and Reports |
Serum Glutathione in Adolescent Males Predicts Parental Coronary Heart Disease
From the Division of Cardiology, Department of Pediatrics, University of Cincinnati College of Medicine and Children’s Hospital Medical Center, Cincinnati, Ohio (J.A.M., P.K., S.R.D.), and Departments of Cell Biology, Lerner Research Institute (D.W.J.) and Cardiology (D.L.S., K.R.), The Cleveland Clinic Foundation, Cleveland, Ohio.
Correspondence to Stephen R. Daniels, MD, PhD, Division of Cardiology, Children’s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229. E-mail sdaniels{at}chmcc.org
Background—Traditional risk factors account for only half of the morbidity and mortality from coronary heart disease (CHD). There is substantial evidence that oxidative injury plays a major role in the atherosclerotic process. Thus, antioxidants may protect against development of atherosclerosis. Glutathione, an intracellular tripeptide with antioxidant properties, may be protective.
Methods and Results—This case-control study compared total serum glutathione (tGSH) in 81 adolescent male offspring of parents with premature CHD (ie, before 56 years of age) and 78 control male offspring of parents without known or suspected CHD. Case offspring had significantly lower tGSH than control offspring. In multiple logistic regression with parental CHD status as the dependent variable, age entered as a covariate, and other CHD risk factors competing to enter the model as significant independent predictor variables, LDL cholesterol (odds ratio [OR], 2.15 [units=1.5 SD]; 95% CI, 1.21 to 3.82), tGSH (OR, 0.40; 95% CI, 0.22 to 0.71), HDL cholesterol (OR, 0.42; 95% CI, 0.22 to 0.78), and total serum homocysteine (OR, 2.6; 95% CI, 1.35 to 5.02) entered the model as significant predictors of parental CHD status.
Conclusions—Low tGSH in adolescent boys is a significant independent predictor of parental CHD, in addition to elevated LDL cholesterol, low HDL cholesterol, and elevated total serum homocysteine concentrations.
Key Words: cholesterol • coronary disease • antioxidants
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