(Circulation. 1999;100:82-86.)
© 1999 American Heart Association, Inc.
Basic Science Reports |
Effect of Metoprolol Administration on Renal Sodium Handling in Experimental Congestive Heart Failure
From the Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa.
Background—Long-term metoprolol therapy improves cardiac performance and decreases mortality in patients with chronic congestive heart failure (CHF). This study examined the effect of long-term metoprolol therapy on renal sodium handling in an experimental rat model of CHF.
Methods and Results—Rats with left coronary ligation and
myocardial infarction–induced CHF were treated with metoprolol (1.5
mg · kg-1 · h-1) or vehicle for
3 weeks by osmotic minipump. They were then evaluated for their ability
to excrete a short-term sodium load (5% body weight isotonic saline
infusion over 30 minutes) and a long-term sodium load (change from low-
to high-sodium diet over 8 days). All CHF rats had left
ventricular end-diastolic pressure >10
mm Hg, and heart weight/body weight ratios averaged 0.68±0.02%
(versus control of 
0.40%). Compared with vehicle CHF rats (n=19),
metoprolol CHF rats (n=18) had lower basal values of mean
arterial pressure (122±3 versus 112±3 mm Hg) and
heart rate (373±14 versus 315±9 bpm) and decreased heart rate
responses to intravenous doses of isoproterenol. During
short-term isotonic saline volume loading, metoprolol CHF rats excreted
54±4% more of the sodium load than vehicle CHF rats. During long-term
dietary sodium loading, metoprolol CHF rats retained 28±3% less
sodium than vehicle CHF rats.
Conclusions—Metoprolol treatment of rats with CHF results in an improved ability to excrete both short- and long-term sodium loads.
Key Words: receptors, adrenergic, beta • heart failure • metoprolol tartrate • kidney
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