Published Online
on May 2, 2005

A more recent version of this article appeared on May 17, 2005

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Submitted on July 28, 2004
Revised on November 12, 2004
Accepted on January 26, 2005

Association of Prolonged QRS Duration With Death in a Clinical Trial of Pacemaker Therapy for Sinus Node Dysfunction

Michael O. Sweeney MD^*, Anne S. Hellkamp MS, Kerry L. Lee PhD, Gervasio A. Lamas MD, for the Mode Selection Trial (MOST) Investigators

From Brigham and Women’s Hospital and Harvard Medical School (M.O.S.), Boston, Mass; Duke Clinical Research Institute and Duke University Medical Center (A.S.H., K.L.L.), Durham, NC; and Mt. Sinai Medical Center (G.A.L.), Miami, Fla.

^* To whom correspondence should be addressed. E-mail: mosweeney{at}partners.org.

Background--Prolonged QRS duration (QRSd) is an important prognostic indicator for death and heart failure hospitalization in patients with systolic heart failure. The relationship of baseline QRSd to death and heart failure hospitalization in patients with sinus node dysfunction who require pacemaker therapy is unknown.

Methods and Results--Baseline QRSd from 12-lead ECGs before pacemaker implantation were analyzed in the Mode Selection Trial (MOST), a 6-year, 2010-patient randomized trial of dual-chamber versus ventricular pacing in sinus node dysfunction. Baseline QRSd was 120 ms in 23.4% of patients and was associated with older age, lower ejection fraction, cardiomyopathy, and prior heart failure. Adjusted Cox models demonstrated baseline QRSd 120 ms was a strong independent predictor of death (hazard ratio [95% CI] 1.35 [1.07, 1.70], P=0.010) but not heart failure hospitalization. The risk of death increased with increased QRSd from 60 to 120 ms (P=0.002 and hazard ratio [95% CI] 1.14 [1.05, 1.23] for 10-ms increase in this range) after adjustment for other death predictors.

Conclusions--Baseline QRSd 120 ms was associated with increased risk of death during pacemaker therapy for sinus node dysfunction.

Key words: pacing • heart failure • mortality

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