on January 17, 2005
Published online before print January 17, 2005, doi: 10.1161/01.CIR.0000153349.77489.CF
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on April 30, 2004
From the Department of Internal Medicine (S.D.K., K.H., A.H., A.Y.), Yale University School of Medicine, New Haven, Conn, and the Department of Medicine (I.H., K.B., C.D.), Columbia University College of Physicians and Surgeons, New York, NY. * To whom correspondence should be addressed. E-mail: stuart.katz{at}yale.edu.
Background--Endothelial function is known to be impaired in subjects with chronic heart failure (CHF), but the association between endothelial function and subsequent mortality risk in CHF has not been previously reported. Methods and Results--Biomarkers of endothelial function in the systemic arterial circulation (flow-mediated dilation [FMD] in the brachial artery) and the pulmonary circulation (exhaled nitric oxide [NO] production during submaximal exercise) were prospectively assessed in 259 subjects with New York Heart Association class II-III CHF. In subjects with FMD measurements (n=149), there were 12 deaths and 5 urgent transplantations over a median follow-up period of 841 days. In subjects with exhaled NO production measurements (n=110), there were 18 deaths and 1 urgent transplantation over a median follow-up period of 396 days. Both decreased FMD and decreased exhaled NO production were associated with increased risk of death or urgent transplantation after adjustment for other known CHF prognostic factors (age, etiology of CHF, functional class, left ventricular ejection fraction) in Cox multivariate proportional-hazards models (adjusted hazard ratio [HR] estimate for a 1% decrease in FMD=1.20; 95% confidence interval [CI], 1.03 to 1.45; P=0.027; adjusted HR estimate for a 1-ppb/min decrease in exhaled NO production=1.31, 95% CI, 1.01 to 1.69, P=0.04). Conclusions--Endothelial dysfunction in CHF, as assessed by FMD in the brachial artery and exhaled NO production during submaximal exercise, is associated with an increased mortality risk in subjects with both ischemic and nonischemic CHF.
Revised on September 15, 2004
Accepted on September 24, 2004
Vascular Endothelial Dysfunction and Mortality Risk in Patients With Chronic Heart Failure
Stuart D. Katz MD*,
Key words: nitric oxide • endothelium • heart failure • survival
Related Article:
Circulation 2005 111: 245.
This article has been cited by other articles:
 |
|
 |
|
  H. Y. Choi, J. E. Lee, S. H. Han, T. H. Yoo, B. S. Kim, H. C. Park, S.-W. Kang, K. H. Choi, S. K. Ha, H. Y. Lee, et al. Association of inflammation and protein-energy wasting with endothelial dysfunction in peritoneal dialysis patients Nephrol. Dial. Transplant., November 19, 2009; (2009) gfp598v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Yamamoto, K. Kataoka, Y.-F. Dong, T. Nakamura, M. Fukuda, Y. Tokutomi, S. Matsuba, H. Nako, N. Nakagata, T. Kaneko, et al. Aliskiren Enhances the Protective Effects of Valsartan Against Cardiovascular and Renal Injury in Endothelial Nitric Oxide Synthase-Deficient Mice Hypertension, September 1, 2009; 54(3): 633 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Klosinska, T. Rudzinski, P. Grzelak, L. Stefanczyk, J. Drozdz, and M. Krzeminska-Pakula Endothelium-dependent and -independent vasodilation is more attenuated in ischaemic than in non-ischaemic heart failure Eur J Heart Fail, August 1, 2009; 11(8): 765 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shechter, S. Matetzky, M. Arad, M. S. Feinberg, and D. Freimark Vascular endothelial function predicts mortality risk in patients with advanced ischaemic chronic heart failure Eur J Heart Fail, June 1, 2009; 11(6): 588 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. P. van der Zwan, T. Teerlink, J. M. Dekker, R. M. A. Henry, C. D. A. Stehouwer, C. Jakobs, R. J. Heine, and P. G. Scheffer Circulating oxidized LDL: determinants and association with brachial flow-mediated dilation J. Lipid Res., February 1, 2009; 50(2): 342 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Guazzi and R Arena Endothelial dysfunction and pathophysiological correlates in atrial fibrillation Heart, January 15, 2009; 95(2): 102 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Fossum, B. Olszewska-Pazdrak, M. M. Mertens, L. A. Makarski, M. W. Miller, T. W. Hein, L. Kuo, F. Clubb, G. M. Fuller, and D. H. Carney TP508 (Chrysalin(R)) Reverses Endothelial Dysfunction and Increases Perfusion and Myocardial Function in Hearts With Chronic Ischemia Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2008; 13(3): 214 - 225. [Abstract] [PDF]
|
|
|
|
|
|
E. Yamamoto, Y.-F. Dong, K. Kataoka, T. Yamashita, Y. Tokutomi, S. Matsuba, H. Ichijo, H. Ogawa, and S. Kim-Mitsuyama Olmesartan Prevents Cardiovascular Injury and Hepatic Steatosis in Obesity and Diabetes, Accompanied by Apoptosis Signal Regulating Kinase-1 Inhibition Hypertension, September 1, 2008; 52(3): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fraccarollo, J. D. Widder, P. Galuppo, T. Thum, D. Tsikas, M. Hoffmann, H. Ruetten, G. Ertl, and J. Bauersachs Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction Circulation, August 19, 2008; 118(8): 818 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dhindsa, S. M. Sommerlad, A. E. DeVan, J. N. Barnes, J. Sugawara, O. Ley, and H. Tanaka Interrelationships among noninvasive measures of postischemic macro- and microvascular reactivity J Appl Physiol, August 1, 2008; 105(2): 427 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Rabelo, K. Ruschel, H. Moreno Jr., M. Rubira, F. M. Consolim-Colombo, M. C. Irigoyen, and L. E. Rohde Venous endothelial function in heart failure: Comparison with healthy controls and effect of clinical compensation Eur J Heart Fail, August 1, 2008; 10(8): 758 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Flammer, I. Sudano, F. Hermann, S. Gay, A. Forster, M. Neidhart, P. Kunzler, F. Enseleit, D. Periat, M. Hermann, et al. Angiotensin-Converting Enzyme Inhibition Improves Vascular Function in Rheumatoid Arthritis Circulation, April 29, 2008; 117(17): 2262 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Yamamoto, K. Kataoka, H. Shintaku, T. Yamashita, Y. Tokutomi, Y.-F. Dong, S. Matsuba, H. Ichijo, H. Ogawa, and S. Kim-Mitsuyama Novel Mechanism and Role of Angiotensin II Induced Vascular Endothelial Injury in Hypertensive Diastolic Heart Failure Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2569 - 2575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Guazzi, M. Samaja, R. Arena, M. Vicenzi, and M. D. Guazzi Long-Term Use of Sildenafil in the Therapeutic Management of Heart Failure J. Am. Coll. Cardiol., November 27, 2007; 50(22): 2136 - 2144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Sartorio, D. Fraccarollo, P. Galuppo, M. Leutke, G. Ertl, I. Stefanon, and J. Bauersachs Mineralocorticoid Receptor Blockade Improves Vasomotor Dysfunction and Vascular Oxidative Stress Early After Myocardial Infarction Hypertension, November 1, 2007; 50(5): 919 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zheng, M. Patel, R. Cable, L. Young, and S. D. Katz Insulin Sensitivity, Vascular Function, and Iron Stores in Voluntary Blood Donors Diabetes Care, October 1, 2007; 30(10): 2685 - 2689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mittermayer, G. Schaller, J. Pleiner, K. Krzyzanowska, S. Kapiotis, M. Roden, and M. Wolzt Rosiglitazone Prevents Free Fatty Acid-Induced Vascular Endothelial Dysfunction J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2574 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.H. W. Tang, W. Tong, R. W. Troughton, M. G. Martin, K. Shrestha, A. Borowski, S. Jasper, S. L. Hazen, and A. L. Klein Prognostic Value and Echocardiographic Determinants of Plasma Myeloperoxidase Levels in Chronic Heart Failure J. Am. Coll. Cardiol., June 19, 2007; 49(24): 2364 - 2370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Kissel, R. Lehmann, B. Assmus, A. Aicher, J. Honold, U. Fischer-Rasokat, C. Heeschen, I. Spyridopoulos, S. Dimmeler, and A. M. Zeiher Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure J. Am. Coll. Cardiol., June 19, 2007; 49(24): 2341 - 2349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Kullo and A. R. Malik Arterial Ultrasonography and Tonometry as Adjuncts to Cardiovascular Risk Stratification J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1413 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Hoare, E. J. Birks, C. Bowles, N. Marczin, and M. H. Yacoub In vitro endothelial cell activation and inflammatory responses in end-stage heart failure J Appl Physiol, November 1, 2006; 101(5): 1466 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hilfiker-Kleiner, U. Landmesser, and H. Drexler Molecular Mechanisms in Heart Failure: Focus on Cardiac Hypertrophy, Inflammation, Angiogenesis, and Apoptosis J. Am. Coll. Cardiol., October 27, 2006; 48(9_Suppl_A): A56 - A66. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Iida, Y. Chu, R. M. Weiss, Y. M. Kang, F. M. Faraci, and D. D. Heistad Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H914 - H920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Heistad Oxidative Stress and Vascular Disease: 2005 Duff Lecture Arterioscler Thromb Vasc Biol, April 1, 2006; 26(4): 689 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. N. Bairey Merz, L. J. Shaw, S. E. Reis, V. Bittner, S. F. Kelsey, M. Olson, B. D. Johnson, C. J. Pepine, S. Mankad, B. L. Sharaf, et al. Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part II: Gender Differences in Presentation, Diagnosis, and Outcome With Regard to Gender-Based Pathophysiology of Atherosclerosis and Macrovascular and Microvascular Coronary Disease J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S21 - S29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Haider, R. A. Bucek, A. G. Giurgea, G. Maurer, H. Glogar, E. Minar, M. Wolzt, M. R. Mehrabi, and M. Baghestanian PGE1 analog alprostadil induces VEGF and eNOS expression in endothelial cells Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2066 - H2072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lundberg, E. Weitzberg, S. D. Katz, K. Hryniewicz, A. Hudaihed, A. Yasskiy, I. Hriljac, K. Balidemaj, and C. Dimayuga Letter Regarding the Article by Katz et al, "Vascular Endothelial Dysfunction and Mortality Risk in Patients With Chronic Heart Failure" * Response Circulation, August 9, 2005; 112(6): e84 - e84. [Full Text] [PDF]
|
|
|
|
|
|
H. Zheng, R. Cable, B. Spencer, N. Votto, and S. D. Katz Iron Stores and Vascular Function in Voluntary Blood Donors Arterioscler Thromb Vasc Biol, August 1, 2005; 25(8): 1577 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Heitzer, S. Baldus, Y. von Kodolitsch, V. Rudolph, and T. Meinertz Systemic Endothelial Dysfunction as an Early Predictor of Adverse Outcome in Heart Failure Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1174 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mittermayer, G. Schaller, J. Pleiner, A. Vychytil, G. Sunder-Plassmann, W. H. Horl, and M. Wolzt Asymmetrical Dimethylarginine Plasma Concentrations Are Related to Basal Nitric Oxide Release but Not Endothelium-Dependent Vasodilation of Resistance Arteries in Peritoneal Dialysis Patients J. Am. Soc. Nephrol., June 1, 2005; 16(6): 1832 - 1838. [Abstract] [Full Text] [PDF]
|
|