on November 8, 2004
Circulation. 2004
Published online before print November 8, 2004, doi: 10.1161/01.CIR.0000147780.30124.CF
Published online before print November 8, 2004, doi: 10.1161/01.CIR.0000147780.30124.CF
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on April 24, 2004
From the Departments of Cardiology (J.D.A., Y.H., D.L., R.H., F.J.G.) and Laboratory Medicine (D.S.K.), Yale University Medical School, New Haven, Conn. * To whom correspondence should be addressed. E-mail: frank.giordano{at}yale.edu.
Background--After myocardial infarction (MI), bone marrow-derived cells (BMDCs) are found within the myocardium. The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell-derived factor-1 Methods and Results--MI produced in mice by coronary ligation induced SDF-1 mRNA and protein expression in the infarct and border zone and decreased serum SDF-1 levels. By quantitative polymerase chain reaction, 48 hours after intravenous infusion of donor-lineage BMDCs, there were 80.5±15.6% more BDMCs in infarcted hearts compared with sham-operated controls (P<0.01). Administration of AMD3100, which specifically blocks binding of SDF-1 to its endogenous receptor CXCR4, diminished BMDC recruitment after MI by 64.2±5.5% (P<0.05), strongly suggesting a requirement for SDF-1 in BMDC recruitment to the infarcted heart. Forced expression of SDF-1 in the heart by adenoviral gene delivery 48 hours after MI doubled BMDC recruitment over MI alone (P<0.001) but did not enhance recruitment in the absence of MI, suggesting that SDF-1 can augment, but is not singularly sufficient for, BDMC recruitment to the heart. Gene expression analysis after MI revealed increased levels of several genes in addition to SDF-1, including those for vascular endothelial growth factor, matrix metalloproteinase-9, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1, which might act in concert with SDF-1 to recruit BMDCs to the injured heart. Conclusion--SDF-1/CXCR4 interactions play a crucial role in the recruitment of BMDCs to the heart after MI and can further increase homing in the presence, but not in the absence, of injury.
Revised on June 21, 2004
Accepted on August 3, 2004
Stromal Cell-Derived Factor-1
J. Dawn Abbott MD, 
Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury
(SDF-1) in this process.
Key words: cell adhesion molecules • cells • growth factors • myocardial infarction
This article has been cited by other articles:
 |
|
 |
|
  K. H. Schuleri, G. S. Feigenbaum, M. Centola, E. S. Weiss, J. M. Zimmet, J. Turney, J. Kellner, M. M. Zviman, K. E. Hatzistergos, B. Detrick, et al. Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy Eur. Heart J., November 2, 2009; 30(22): 2722 - 2732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Post, A. M. Smits, A. J. van den Broek, J. P.G. Sluijter, I. E. Hoefer, B. J. Janssen, R. J. Snijder, J. J. Mager, G. Pasterkamp, C. L. Mummery, et al. Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance Cardiovasc Res, October 8, 2009; (2009) cvp313v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Dotsenko and M. Jahangiri Endogenous stem cells in patients undergoing coronary artery bypass graft surgery Eur. J. Cardiothorac. Surg., September 1, 2009; 36(3): 563 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-M. Lee, C.-C. Chen, and N.-C. Chang Granulocyte colony-stimulating factor increases sympathetic reinnervation and the arrhythmogenic response to programmed electrical stimulation after myocardial infarction in rats Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H512 - H522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. McKitrick The arrythmogenic potential of post-myocardial infarction cytokine treatment Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H508 - H509. [Full Text] [PDF]
|
|
|
|
 |
|
 I. Stroo, G. Stokman, G. J. D. Teske, S. Florquin, and J. C. Leemans Haematopoietic stem cell migration to the ischemic damaged kidney is not altered by manipulating the SDF-1/CXCR4-axis Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2082 - 2088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, E. T. Gonzalez, S. S. Iyer, V. Mac, A. L. Mora, R. L. Sutliff, A. Reed, K. L. Brigham, P. Kelly, and M. Rojas Use of Senescence-Accelerated Mouse Model in Bleomycin-Induced Lung Injury Suggests That Bone Marrow-Derived Cells Can Alter the Outcome of Lung Injury in Aged Mice J Gerontol A Biol Sci Med Sci, July 1, 2009; 64A(7): 731 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B-C Lee, H-C Hsu, W-Y I Tseng, M-Y M Su, S-Y Chen, Y-W Wu, K-L Chien, and M-F Chen Effect of cardiac rehabilitation on angiogenic cytokines in postinfarction patients Heart, June 15, 2009; 95(12): 1012 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Young, E. Torres, K. E. Hatzistergos, D. Hehre, C. Suguihara, and J. M. Hare Inhibition of the SDF-1/CXCR4 Axis Attenuates Neonatal Hypoxia-Induced Pulmonary Hypertension Circ. Res., June 5, 2009; 104(11): 1293 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Tang, W. Zhu, M. Cheng, L. Chen, J. Zhang, T. Sun, R. Kishore, M. I. Phillips, D. W. Losordo, and G. Qin Hypoxic Preconditioning Enhances the Benefit of Cardiac Progenitor Cell Therapy for Treatment of Myocardial Infarction by Inducing CXCR4 Expression Circ. Res., May 22, 2009; 104(10): 1209 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stellos, B. Bigalke, H. Langer, T. Geisler, A. Schad, A. Kogel, F. Pfaff, D. Stakos, P. Seizer, I. Muller, et al. Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells Eur. Heart J., March 1, 2009; 30(5): 584 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Hohensinner, C. Kaun, K. Rychli, A. Niessner, S. Pfaffenberger, G. Rega, A. Furnkranz, P. Uhrin, J. Zaujec, T. Afonyushkin, et al. The inflammatory mediator oncostatin M induces stromal derived factor-1 in human adult cardiac cells FASEB J, March 1, 2009; 23(3): 774 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Vela, G. V. Silva, J. A.R. Assad, A. L.S. Sousa, S. Coulter, M. R. Fernandes, E. C. Perin, J. T. Willerson, and L. M. Buja Histopathological Study of Healing After Allogenic Mesenchymal Stem Cell Delivery in Myocardial Infarction in Dogs J. Histochem. Cytochem., February 1, 2009; 57(2): 167 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brunner, J. Winogradow, B. C. Huber, M.-M. Zaruba, R. Fischer, R. David, G. Assmann, N. Herbach, R. Wanke, J. Mueller-Hoecker, et al. Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axis FASEB J, February 1, 2009; 23(2): 351 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wojakowski, M. Tendera, M. Kucia, E. Zuba-Surma, E. Paczkowska, J. Ciosek, M. Halasa, M. Krol, M. Kazmierski, P. Buszman, et al. Mobilization of bone marrow-derived Oct-4+ SSEA-4+ very small embryonic-like stem cells in patients with acute myocardial infarction. J. Am. Coll. Cardiol., January 6, 2009; 53(1): 1 - 9. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Lin, Y.-S. Chen, H.-S. Chiang, and M.-C. Ma Hypoxic preconditioning protects rat hearts against ischaemia-reperfusion injury: role of erythropoietin on progenitor cell mobilization J. Physiol., December 1, 2008; 586(23): 5757 - 5769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wojakowski, M. Kucia, K. Milewski, B. Machalinski, M. Halasa, P. Buszman, P. Klimeczek, M. Kazmierski, M. Pasowicz, M. Z. Ratajczak, et al. The role of CXCR4/SDF-1, CD117/SCF, and c-met/HGF chemokine signalling in the mobilization of progenitor cells and the parameters of the left ventricular function, remodelling, and myocardial perfusion following acute myocardial infarction Eur. Heart J. Suppl., December 1, 2008; 10(suppl_K): K16 - K23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tang, J. Wang, J. Yang, and X. Kong Adenovirus-mediated stromal cell-derived- factor-1{alpha} gene transfer induces cardiac preservation after infarction via angiogenesis of CD133+ stem cells and anti-apoptosis Interactive CardioVascular and Thoracic Surgery, October 1, 2008; 7(5): 767 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kyriakou, N. Rabin, A. Pizzey, A. Nathwani, and K. Yong Factors that influence short-term homing of human bone marrow-derived mesenchymal stem cells in a xenogeneic animal model Haematologica, October 1, 2008; 93(10): 1457 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Carr, D. J. Stuckey, L. Tatton, D. J. Tyler, S. J. M. Hale, D. Sweeney, J. E. Schneider, E. Martin-Rendon, G. K. Radda, S. E. Harding, et al. Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H533 - H542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Penn and A. A. Mangi Genetic Enhancement of Stem Cell Engraftment, Survival, and Efficacy Circ. Res., June 20, 2008; 102(12): 1471 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Misra, D. Lebeche, H. Ly, M. Schwarzkopf, G. Diaz, R. J. Hajjar, A. D. Schecter, and J. V. Frangioni Quantitation of CXCR4 Expression in Myocardial Infarction Using 99mTc-Labeled SDF-1{alpha} J. Nucl. Med., June 1, 2008; 49(6): 963 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ray, C. M. Herring, T. A. Markel, P. R. Crisostomo, M. Wang, B. Weil, T. Lahm, and D. R. Meldrum Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1498 - R1503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Saxena, J. E. Fish, M. D. White, S. Yu, J. W.P. Smyth, R. M. Shaw, J. M. DiMaio, and D. Srivastava Stromal Cell-Derived Factor-1{alpha} Is Cardioprotective After Myocardial Infarction Circulation, April 29, 2008; 117(17): 2224 - 2231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Mallat PI3K{gamma} Helps an SDF Seeking Home ... for EPCs Circ. Res., April 25, 2008; 102(8): 871 - 872. [Full Text] [PDF]
|
|
|
|
|
|
E. Chavakis, G. Carmona, C. Urbich, S. Gottig, R. Henschler, J. M. Penninger, A. M. Zeiher, T. Chavakis, and S. Dimmeler Phosphatidylinositol-3-Kinase-{gamma} Is Integral to Homing Functions of Progenitor Cells Circ. Res., April 25, 2008; 102(8): 942 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tillmanns, M. Rota, T. Hosoda, Y. Misao, G. Esposito, A. Gonzalez, S. Vitale, C. Parolin, S. Yasuzawa-Amano, J. Muraski, et al. Formation of large coronary arteries by cardiac progenitor cells PNAS, February 5, 2008; 105(5): 1668 - 1673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stellos, H. Langer, K. Daub, T. Schoenberger, A. Gauss, T. Geisler, B. Bigalke, I. Mueller, M. Schumm, I. Schaefer, et al. Platelet-Derived Stromal Cell-Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to Endothelial Progenitor Cells Circulation, January 15, 2008; 117(2): 206 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W Wojakowski, M Kucia, M Kazmierski, M Z Ratajczak, and M Tendera Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: relevant reparatory mechanism? Heart, January 1, 2008; 94(1): 27 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Valina, K. Pinkernell, Y.-H. Song, X. Bai, S. Sadat, R. J. Campeau, T. H. Le Jemtel, and E. Alt Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction Eur. Heart J., November 1, 2007; 28(21): 2667 - 2677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. F.M. Segers, T. Tokunou, L. J. Higgins, C. MacGillivray, J. Gannon, and R. T. Lee Local Delivery of Protease-Resistant Stromal Cell Derived Factor-1 for Stem Cell Recruitment After Myocardial Infarction Circulation, October 9, 2007; 116(15): 1683 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhang, N. Mal, M. Kiedrowski, M. Chacko, A. T. Askari, Z. B. Popovic, O. N. Koc, and M. S. Penn SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction FASEB J, October 1, 2007; 21(12): 3197 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, A. Mora, H. Shim, A. Stecenko, K. L. Brigham, and M. Rojas Role of the SDF-1/CXCR4 Axis in the Pathogenesis of Lung Injury and Fibrosis Am. J. Respir. Cell Mol. Biol., September 1, 2007; 37(3): 291 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Hu, S. Dai, W.-J. Wu, W. Tan, X. Zhu, J. Mu, Y. Guo, R. Bolli, and G. Rokosh Stromal Cell Derived Factor-1{alpha} Confers Protection Against Myocardial Ischemia/Reperfusion Injury: Role of the Cardiac Stromal Cell Derived Factor-1{alpha} CXCR4 Axis Circulation, August 7, 2007; 116(6): 654 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Ip, Y. Wu, J. Huang, L. Zhang, R. E. Pratt, and V. J. Dzau Mesenchymal Stem Cells Use Integrin beta1 Not CXC Chemokine Receptor 4 for Myocardial Migration and Engraftment Mol. Biol. Cell, August 1, 2007; 18(8): 2873 - 2882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Joseph The stem cell army in heart failure: do we mobilize or pave the way home? Eur. Heart J., May 5, 2007; (2007) ehm155v1. [Full Text] [PDF]
|
|
|
|
|
|
H. D. Theiss, R. David, M. G. Engelmann, A. Barth, K. Schotten, M. Naebauer, B. Reichart, G. Steinbeck, and W.-M. Franz Circulation of CD34+ progenitor cell populations in patients with idiopathic dilated and ischaemic cardiomyopathy (DCM and ICM) Eur. Heart J., May 2, 2007; 28(10): 1258 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhang, E. Shpall, J. T. Willerson, and E. T.H. Yeh Fusion of Human Hematopoietic Progenitor Cells and Murine Cardiomyocytes Is Mediated by {alpha}4{beta}1 Integrin/Vascular Cell Adhesion Molecule-1 Interaction Circ. Res., March 16, 2007; 100(5): 693 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Honold, R. Lehmann, C. Heeschen, D. H. Walter, B. Assmus, K.-I. Sasaki, H. Martin, J. Haendeler, A. M. Zeiher, and S. Dimmeler Effects of Granulocyte Colony Stimulating Factor on Functional Activities of Endothelial Progenitor Cells in Patients With Chronic Ischemic Heart Disease Arterioscler Thromb Vasc Biol, October 1, 2006; 26(10): 2238 - 2243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, J. E. Ip, J. Huang, L. Zhang, K. Matsushita, C.-C. Liew, R. E. Pratt, and V. J. Dzau Essential Role of ICAM-1/CD18 in Mediating EPC Recruitment, Angiogenesis, and Repair to the Infarcted Myocardium Circ. Res., August 4, 2006; 99(3): 315 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mieno, M. Boodhwani, B. Ramlawi, J. Li, J. Feng, C. Bianchi, R. J. Laham, J. Li, and F. W. Sellke Human Coronary Microvascular Effects of Cardioplegia-Induced Stromal-Derived Factor-1{alpha} Ann. Thorac. Surg., August 1, 2006; 82(2): 657 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Ripa, Y. Wang, E. Jorgensen, H. E. Johnsen, B. Hesse, and J. Kastrup Intramyocardial injection of vascular endothelial growth factor-A165 plasmid followed by granulocyte-colony stimulating factor to induce angiogenesis in patients with severe chronic ischaemic heart disease Eur. Heart J., August 1, 2006; 27(15): 1785 - 1792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Misao, G. Takemura, M. Arai, T. Ohno, H. Onogi, T. Takahashi, S. Minatoguchi, T. Fujiwara, and H. Fujiwara Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF Cardiovasc Res, August 1, 2006; 71(3): 455 - 465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mieno, B. Ramlawi, M. Boodhwani, R. T. Clements, K. Minamimura, T. Maki, S.-H. Xu, C. Bianchi, J. Li, and F. W. Sellke Role of Stromal-Derived Factor-1{alpha} in the Induction of Circulating CD34+CXCR4+ Progenitor Cells After Cardiac Surgery. Circulation, July 4, 2006; 114(1 Suppl): 186 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Kang, H.-Y. Lee, S.-H. Na, S.-A Chang, K.-W. Park, H.-K. Kim, S.-Y. Kim, H.-J. Chang, W. Lee, W. J. Kang, et al. Differential Effect of Intracoronary Infusion of Mobilized Peripheral Blood Stem Cells by Granulocyte Colony-Stimulating Factor on Left Ventricular Function and Remodeling in Patients With Acute Myocardial Infarction Versus Old Myocardial Infarction: The MAGIC Cell-3-DES Randomized, Controlled Trial Circulation, July 4, 2006; 114(1_suppl): I-145 - I-151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yu, K. Sliedregt-Bol, H. Overkleeft, G. A. van der Marel, T. J.C. van Berkel, and E. A.L. Biessen Therapeutic Potential of a Synthetic Peptide Inhibitor of Nuclear Factor of Activated T Cells as Antirestenotic Agent Arterioscler Thromb Vasc Biol, July 1, 2006; 26(7): 1531 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Wang, H E Johnsen, S Mortensen, L Bindslev, R Sejersten Ripa, M Haack-Sorensen, E Jorgensen, W Fang, and J Kastrup Changes in circulating mesenchymal stem cells, stem cell homing factor, and vascular growth factors in patients with acute ST elevation myocardial infarction treated with primary percutaneous coronary intervention Heart, June 1, 2006; 92(6): 768 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Freyman, G. Polin, H. Osman, J. Crary, M. Lu, L. Cheng, M. Palasis, and R. L. Wilensky A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction Eur. Heart J., May 1, 2006; 27(9): 1114 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-N. Zhang, D. W. Wilson, V. da Cunha, M. E. Sullivan, R. Vergona, J. C. Rutledge, and Y.-X. Wang Endothelial NO Synthase Deficiency Promotes Smooth Muscle Progenitor Cells in Association With Upregulation of Stromal Cell-Derived Factor-1{alpha} in a Mouse Model of Carotid Artery Ligation Arterioscler Thromb Vasc Biol, April 1, 2006; 26(4): 765 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Zohlnhofer, I. Ott, J. Mehilli, K. Schomig, F. Michalk, T. Ibrahim, G. Meisetschlager, J. von Wedel, H. Bollwein, M. Seyfarth, et al. Stem Cell Mobilization by Granulocyte Colony-Stimulating Factor in Patients With Acute Myocardial Infarction: A Randomized Controlled Trial JAMA, March 1, 2006; 295(9): 1003 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wojakowski, M. Tendera, A. Zebzda, A. Michalowska, M. Majka, M. Kucia, K. Maslankiewicz, R. Wyderka, M. Krol, A. Ochala, et al. Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction Eur. Heart J., February 1, 2006; 27(3): 283 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Misao, G. Takemura, M. Arai, S. Sato, K. Suzuki, S. Miyata, K.-i. Kosai, S. Minatoguchi, T. Fujiwara, and H. Fujiwara Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation Cardiovasc Res, February 1, 2006; 69(2): 476 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Muta, G. Matsumoto, E. Nakashima, and M. Toi Mechanical Analysis of Tumor Growth Regression by the Cyclooxygenase-2 Inhibitor, DFU, in a Walker256 Rat Tumor Model: Importance of Monocyte Chemoattractant Protein-1 Modulation Clin. Cancer Res., January 1, 2006; 12(1): 264 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Leri, J. Kajstura, and P. Anversa Cardiac Stem Cells and Mechanisms of Myocardial Regeneration Physiol Rev, October 1, 2005; 85(4): 1373 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Yamani, N. B. Ratliff, D. J. Cook, E. M. Tuzcu, Y. Yu, R. Hobbs, G. Rincon, C. Bott-Silverman, J. B. Young, N. Smedira, et al. Peritransplant Ischemic Injury Is Associated With Up-Regulation of Stromal Cell-Derived Factor-1 J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1029 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Lapidot, A. Dar, and O. Kollet How do stem cells find their way home? Blood, September 15, 2005; 106(6): 1901 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ince, M. Petzsch, H. D. Kleine, H. Eckard, T. Rehders, D. Burska, S. Kische, M. Freund, and C. A. Nienaber Prevention of Left Ventricular Remodeling With Granulocyte Colony-Stimulating Factor After Acute Myocardial Infarction: Final 1-year Results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial Circulation, August 30, 2005; 112(9_suppl): I-73 - I-80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Tang, Q. Zhao, X. Qin, L. Shen, L. Cheng, J. Ge, and M. I. Phillips Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in Rat Model of Myocardial Infarction Ann. Thorac. Surg., July 1, 2005; 80(1): 229 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Guleng, K. Tateishi, M. Ohta, F. Kanai, A. Jazag, H. Ijichi, Y. Tanaka, M. Washida, K. Morikane, Y. Fukushima, et al. Blockade of the Stromal Cell-Derived Factor-1/CXCR4 Axis Attenuates In vivo Tumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor-Independent Manner Cancer Res., July 1, 2005; 65(13): 5864 - 5871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zernecke, A. Schober, I. Bot, P. von Hundelshausen, E. A. Liehn, B. Mopps, M. Mericskay, P. Gierschik, E. A. Biessen, and C. Weber SDF-1{alpha}/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells Circ. Res., April 15, 2005; 96(7): 784 - 791. [Abstract] [Full Text] [PDF]
|
|