on November 8, 2004
Published online before print November 8, 2004, doi: 10.1161/01.CIR.0000147233.10318.23
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Submitted on February 6, 2004
From the Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, and University Health Network, Toronto, Ontario (M.S., F.D., W.W., M.C., P.P.L.), and Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg (I.D., L.A.K.), Canada. Dr Liu holds the Heart and Stroke/Polo Chair Professor of Medicine and Physiology at the University of Toronto; Dr Kirshenbaum is Canada Research Chair in Molecular Cardiology at the University of Manitoba. * To whom correspondence should be addressed. E-mail: peter.liu{at}utoronto.ca.
Background--We investigated the potential contributions of tumor necrosis factor- Methods and Results--Animals were randomized to left anterior descending ligation or sham operation and killed on days 3, 7, 14, and 28. We monitored cardiac rupture rate, cardiac function, inflammatory response, collagen degradation, and net collagen formation. We found the following: (1) within 1 week after MI, 53.3% (n=120) of WT mice died of cardiac rupture, in contrast to 2.5% (n=80) of TNF-/- mice; (2) inflammatory cell infiltration and cytokine expression were significantly higher in the infarct zone in WT than TNF-/- mice on day 3; (3) matrix metalloproteinase-9 and -2 activity in the infarcted myocardium was significantly higher in WT than in TNF-/- mice on day 3; (4) on day 28 after MI compared with sham, there was a significant decrease in LV developed pressure (74%) and ±dP/dtmax (68.3%/65.3%) in WT mice but a less significant decrease in ±dP/dtmax (25.8%/28.8%) in TNF-/- mice; (5) cardiac collagen volume fraction was lower in WT than in TNF-/- mice on days 3 and 7 but higher on day 28 compared with TNF-/- mice; and (6) a reduction in myocyte apoptosis in TNF-/- mice occurred on day 28 compared with WT mice. Conclusions--Elevated local TNF-
Revised on May 17, 2004
Accepted on June 10, 2004
Excessive Tumor Necrosis Factor Activation After Infarction Contributes to Susceptibility of Myocardial Rupture and Left Ventricular Dysfunction
Mei Sun MD, PhD,
(TNF-) on the incidence of acute myocardial rupture and subsequent chronic cardiac dysfunction after myocardial infarction (MI) in TNF knockout (TNF-/-) mice compared with C57/BL wild-type (WT) mice. in the infarcted myocardium contributes to acute myocardial rupture and chronic left ventricle dysfunction by inducing exuberant local inflammatory response, matrix and collagen degradation, increased matrix metalloproteinase activity, and apoptosis.
Key words: myocardial infarction • tumor necrosis factor • metalloproteinases • remodeling
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Circulation 2004 110: 3157.
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