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on October 18, 2004

A more recent version of this article appeared on November 2, 2004

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Submitted on February 19, 2004
Revised on June 30, 2004
Accepted on July 1, 2004

Ascorbic Acid Prevents Contrast-Mediated Nephropathy in Patients With Renal Dysfunction Undergoing Coronary Angiography or Intervention

Konstantinos Spargias MD^*, Elias Alexopoulos MD, Stamatis Kyrzopoulos MD, Panayiotis Iacovis MD, Darren C. Greenwood MSc, Athanassios Manginas MD, Vassilis Voudris MD, Gregory Pavlides MD, Christopher E. Buller MD, Dimitrios Kremastinos MD, and Dennis V. Cokkinos MD

From the Department of Cardiology (K.S., E.A., S.K., P.I., A.M., V.V., G.P., D.K., D.V.C.), Onassis Cardiac Surgery Centre, Athens, Greece; the Biostatistics Unit and Nutrition Epidemiology Group (D.C.G.), University of Leeds, Leeds, UK; and the Division of Cardiology (C.E.B.), University of British Columbia, Vancouver, Canada.

^* To whom correspondence should be addressed. E-mail: spargias{at}ocsc.gr.

Background--Contrast agents can cause a reduction in renal function that may be due to the generation of reactive oxygen species. Conflicting evidence suggests that administration of the antioxidant acetylcysteine prevents this renal impairment. The action of other antioxidant agents has not been investigated.

Methods and Results--We conducted a randomized, double-blind, placebo-controlled trial of ascorbic acid in 231 patients with a serum creatinine concentration 1.2 mg/dL who underwent coronary angiography and/or intervention. Ascorbic acid, 3 g at least 2 hours before the procedure and 2 g in the night and the morning after the procedure, or placebo was administered orally. Contrast-mediated nephropathy was defined by an absolute increase of serum creatinine 0.5 mg/dL or a relative increase of 25% measured 2 to 5 days after the procedure. Contrast-mediated nephropathy occurred in 11 of the 118 patients (9%) in the ascorbic acid group and in 23 of the 113 patients (20%) in the placebo group (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.17 to 0.85; P=0.02). The mean serum creatinine concentration increased significantly in the placebo group (from 1.36±0.50 to 1.50±0.54 mg/dL, P<0.001) and nonsignificantly in the ascorbic acid group (from 1.46±0.52 to 1.52±0.64 mg/dL, P=0.07). The mean increase in serum creatinine concentration was greater in the placebo group than in the ascorbic acid group (difference of 0.09 mg/dL; 95% CI, 0.00 to 0.17; P=0.049).

Conclusions--Prophylactic oral administration of ascorbic acid may protect against contrast-mediated nephropathy in high-risk patients undergoing a coronary procedure.

Key words: contrast media • kidney • angiography • angioplasty • antioxidants

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