Published Online
on October 18, 2004

A more recent version of this article appeared on October 26, 2004

This Article Full Text (PDF) All Versions of this Article: 110/17/2575    most recent 01.CIR.0000145543.88293.21v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Stewart, J. M. Articles by Montgomery, L. D. Search for Related Content PubMed PubMed Citation Articles by Stewart, J. M. Articles by Montgomery, L. D. Related Collections Other diagnostic testing Other Vascular biology

Submitted on February 5, 2004
Revised on April 1, 2004
Accepted on April 7, 2004

Relation of Postural Vasovagal Syncope to Splanchnic Hypervolemia in Adolescents

Julian M. Stewart MD, PhD^*, Kenneth J. McLeod PhD, Sanjukta Sanyal BA, Gilbert Herzberg MD, and Leslie D. Montgomery PhD

From the Departments of Pediatrics (J.M.S., G.H.) and Physiology (J.M.S.) and the Medical College (S.S.), New York Medical College, Valhalla, NY; the State University of New York at Binghamton (K.J.M.); and LDM Associates, San Jose, Calif (L.D.M.).

^* To whom correspondence should be addressed. E-mail: stewart{at}nymc.edu.

Background--The mechanisms of simple faint remain elusive. We propose that postural fainting is related to excessive thoracic hypovolemia and splanchnic hypervolemia during orthostasis compared with healthy subjects.

Methods and Results--We studied 34 patients 12 to 22 years old referred for multiple episodes of postural faint and 11 healthy subjects. Subjects were studied in the supine position and during upright tilt to 70° for 30 minutes and subgrouped into S+, historical fainters who fainted during testing (n=24); S-, historical fainters who did not faint during testing (n=10); and control subjects. Supine venous occlusion plethysmography showed no differences between blood flows of the forearm and calf in S+, S-, or control. Cardiac index, total peripheral resistance, and blood volume were not different. Using impedance plethysmography, we assessed blood redistribution during upright tilt. This demonstrated decreased thoracic blood volume and increased splanchnic, pelvic, and leg blood volumes for all subjects. However, thoracic blood volume was decreased in S+ compared with control volume, correlating well with the maximum upright heart rate. Splanchnic volume was decreased in the S+ and S- groups, correlating with the change in thoracic blood volume. Pelvic and leg volume changes were similar for all groups and uncorrelated to thoracic blood volume.

Conclusions--Enhanced postural thoracic hypovolemia and splanchnic hypervolemia are associated with postural simple faint.

Key words: syncope • blood volume • hypovolemia

This article has been cited by other articles:

				G. Styczynski, M. Jaltuszewska, N. Kosiorowska, M. Kostrzewska, and C. Szmigielski Dilated Inferior Vena Cava in Young Adults With Vasovagal Syncope Arch Intern Med, September 28, 2009; 169(17): 1634 - 1635. [Full Text] [PDF]

				J. A. Nowak, A. Ocon, I. Taneja, M. S. Medow, and J. M. Stewart Multiresolution wavelet analysis of time-dependent physiological responses in syncopal youths Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H171 - H179. [Abstract] [Full Text] [PDF]

				I. Taneja, M. S. Medow, J. L. Glover, N. K. Raghunath, and J. M. Stewart Increased vasoconstriction predisposes to hyperpnea and postural faint Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H372 - H381. [Abstract] [Full Text] [PDF]

				B. Verheyden, H. Ector, A. E. Aubert, and T. Reybrouck Tilt training increases the vasoconstrictor reserve in patients with neurally mediated syncope evoked by head-up tilt testing Eur. Heart J., June 2, 2008; 29(12): 1523 - 1530. [Abstract] [Full Text] [PDF]

				G. Fuca, M. Dinelli, L. Gianfranchi, S. Bressan, C. Lamborghini, and P. Alboni Do subjects with vasovagal syncope have subtle haemodynamic alterations during orthostatic stress? Europace, June 1, 2008; 10(6): 751 - 759. [Abstract] [Full Text] [PDF]

				J. M. Stewart, I. Taneja, and M. S. Medow Reduced central blood volume and cardiac output and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1908 - H1917. [Abstract] [Full Text] [PDF]

				G. Fuca, M. Dinelli, P. Suzzani, S. Scarfo, F. Tassinari, and P. Alboni The venous system is the main determinant of hypotension in patients with vasovagal syncope Europace, October 1, 2006; 8(10): 839 - 845. [Abstract] [Full Text] [PDF]