on October 11, 2004
Circulation. 2004
Published online before print October 11, 2004, doi: 10.1161/01.CIR.0000145163.56529.D1
Published online before print October 11, 2004, doi: 10.1161/01.CIR.0000145163.56529.D1
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on March 16, 2004
From the Department of Medicine (S.N., A.S.-T., G.S.), Clinical Chemistry (J.L.), and Research Center (A.S.-T., G.S., S.N.), Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada. * To whom correspondence should be addressed. E-mail: stanley.nattel{at}icm-mhi.org.
Background--There is evidence for a role of oxidant stress and inflammation in atrial fibrillation (AF). Statins have both antioxidant and antiinflammatory properties. We compared the effects of simvastatin with those of antioxidant vitamins on AF promotion by atrial tachycardia in dogs. Methods and Results--We studied dogs subjected to atrial tachypacing (ATP) at 400 bpm in the absence and presence of treatment with simvastatin, vitamin C, and combined vitamins C and E. Serial closed-chest electrophysiological studies were performed in each dog at baseline and 2, 4, and 7 days after tachypacing onset. Atrioventricular block was performed to control ventricular rate. Mean duration of induced AF was increased from 42±18 to 1079±341 seconds at terminal open-chest study after tachypacing alone (P<0.01), and atrial effective refractory period (ERP) at a cycle length of 300 ms was decreased from 117±5 to 76±6 ms (P<0.01). Tachypacing-induced ERP shortening and AF promotion were unaffected by vitamin C or vitamins C and E; however, simvastatin suppressed tachypacing-induced remodeling effects significantly, with AF duration and ERP averaging 41±15 seconds and 103±4 ms, respectively, after tachypacing with simvastatin therapy. Tachypacing downregulated L-type Ca2+-channel Conclusions--Simvastatin attenuates AF promotion by atrial tachycardia in dogs, an effect not shared by antioxidant vitamins, and constitutes a potentially interesting new pharmacological approach to preventing the consequences of atrial tachycardia remodeling.
Revised on May 26, 2004
Accepted on May 28, 2004
Effect of Simvastatin and Antioxidant Vitamins on Atrial Fibrillation Promotion by Atrial-Tachycardia Remodeling in Dogs
Akiko Shiroshita-Takeshita MD,
-subunit expression (Western blot), an effect that was unaltered by antioxidant vitamins but greatly attenuated by simvastatin.
Key words: antioxidants • antiarrhythmia agents • electrophysiology
This article has been cited by other articles:
 |
|
 |
|
  K. Nishida, G. Michael, D. Dobrev, and S. Nattel Animal models for atrial fibrillation: clinical insights and scientific opportunities Europace, October 29, 2009; (2009) eup328v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Antoniades, T. Van-Assche, C. Shirodaria, J. Diesch, A. S. Antonopoulos, J. Lee, C. Cunnington, D. Tousoulis, C. Stefanadis, B. Casadei, et al. Preoperative sCD40L Levels Predict Risk of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Graft Surgery Circulation, September 15, 2009; 120(11_suppl_1): S170 - S176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Schroder, M. Byse, and J. Satin L-Type Calcium Channel C Terminus Autoregulates Transcription Circ. Res., June 19, 2009; 104(12): 1373 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C N Pellegrini, E Vittinghoff, F Lin, S B Hulley, and G M Marcus Statin use is associated with lower risk of atrial fibrillation in women with coronary disease: the HERS trial Heart, May 1, 2009; 95(9): 704 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Balasubramaniam and P M Kistler Atrial fibrillation in heart failure: the chicken or the egg? Heart, April 1, 2009; 95(7): 535 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Michael, L. Xiao, X.-Y. Qi, D. Dobrev, and S. Nattel Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis Cardiovasc Res, February 15, 2009; 81(3): 491 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shiroshita-Takeshita, H. Mitamura, S. Ogawa, and S. Nattel Rate-dependence of atrial tachycardia effects on atrial refractoriness and atrial fibrillation maintenance Cardiovasc Res, January 1, 2009; 81(1): 90 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sanchez-Quinones, F. Marin, V. Roldan, and G.Y.H. Lip The impact of statin use on atrial fibrillation QJM, November 1, 2008; 101(11): 845 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Adam, H.-R. Neuberger, M. Bohm, and U. Laufs Prevention of Atrial Fibrillation With 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Circulation, September 16, 2008; 118(12): 1285 - 1293. [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Gillis, M. Morck, D. V. Exner, A. Soo, M. S. Rose, R. S. Sheldon, H. J. Duff, K. M. Kavanagh, L. B. Mitchell, and D. G. Wyse Beneficial effects of statin therapy for prevention of atrial fibrillation following DDDR pacemaker implantation Eur. Heart J., August 1, 2008; 29(15): 1873 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Israel Effect of statins in 'upstream therapy' of atrial fibrillation: better reliability with implantable cardiac monitors Eur. Heart J., August 1, 2008; 29(15): 1798 - 1799. [Full Text] [PDF]
|
|
|
|
|
|
I. Liuba, H. Ahlmroth, L. Jonasson, A. Englund, A. Jonsson, K. Safstrom, and H. Walfridsson Source of inflammatory markers in patients with atrial fibrillation Europace, July 1, 2008; 10(7): 848 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J.J.M. Brundel, L. Ke, A.-J. Dijkhuis, X. Qi, A. Shiroshita-Takeshita, S. Nattel, R. H. Henning, and H. H. Kampinga Heat shock proteins as molecular targets for intervention in atrial fibrillation Cardiovasc Res, June 1, 2008; 78(3): 422 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kourliouros, A. De Souza, N. Roberts, A. Marciniak, A. Tsiouris, O. Valencia, J. Camm, and M. Jahangiri Dose-Related Effect of Statins on Atrial Fibrillation After Cardiac Surgery Ann. Thorac. Surg., May 1, 2008; 85(5): 1515 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nattel, B. Burstein, and D. Dobrev Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications Circ Arrhythm Electrophysiol, April 1, 2008; 1(1): 62 - 73. [Full Text] [PDF]
|
|
|
|
|
|
J. T. Nguyen and D. G. Benditt Atrial Fibrillation Susceptibility in Metabolic Syndrome: Simply the Sum of Its Parts? Circulation, March 11, 2008; 117(10): 1249 - 1251. [Full Text] [PDF]
|
|
|
|
|
|
M. Ozaydin, O. Peker, D. Erdogan, S. Kapan, Y. Turker, E. Varol, F. Ozguner, A. Dogan, and E. Ibrisim N-acetylcysteine for the prevention of postoperative atrial fibrillation: a prospective, randomized, placebo-controlled pilot study Eur. Heart J., March 1, 2008; 29(5): 625 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Casaclang-Verzosa, B. J. Gersh, and T. S.M. Tsang Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation. J. Am. Coll. Cardiol., January 1, 2008; 51(1): 1 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Kim, H. Kattach, C. Ratnatunga, R. Pillai, K. M. Channon, and B. Casadei Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery. J. Am. Coll. Cardiol., January 1, 2008; 51(1): 68 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oral Post-operative atrial fibrillation and oxidative stress: a novel causal mechanism or another biochemical epiphenomenon? J. Am. Coll. Cardiol., January 1, 2008; 51(1): 75 - 76. [Full Text] [PDF]
|
|
|
|
|
|
F. G. Cosio, E. Aliot, G. L. Botto, H. Heidbuchel, C. J. Geller, P. Kirchhof, J.-C. De Haro, R. Frank, J. P. Villacastin, J. Vijgen, et al. Delayed rhythm control of atrial fibrillation may be a cause of failure to prevent recurrences: reasons for change to active antiarrhythmic treatment at the time of the first detected episode Europace, January 1, 2008; 10(1): 21 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. Issac, H. Dokainish, and N. M. Lakkis Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation: A Systematic Review of the Published Data J. Am. Coll. Cardiol., November 20, 2007; 50(21): 2021 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kirchhof, A. Auricchio, J. Bax, H. Crijns, J. Camm, H.-C. Diener, A. Goette, G. Hindricks, S. Hohnloser, L. Kappenberger, et al. Outcome parameters for trials in atrial fibrillation: executive summary: Recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork (AFNET) and the European Heart Rhythm Association (EHRA) Eur. Heart J., November 2, 2007; 28(22): 2803 - 2817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kirchhof, A. Auricchio, J. Bax, H. Crijns, J. Camm, H.-C. Diener, A. Goette, G. Hindricks, S. Hohnloser, L. Kappenberger, et al. Outcome parameters for trials in atrial fibrillation: Recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association Europace, November 1, 2007; 9(11): 1006 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ramlawi, H. Otu, S. Mieno, M. Boodhwani, N. R. Sodha, R. T. Clements, C. Bianchi, and F. W. Sellke Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Ann. Thorac. Surg., October 1, 2007; 84(4): 1166 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Neuman, H. L. Bloom, I. Shukrullah, L. A. Darrow, D. Kleinbaum, D. P. Jones, and S. C. Dudley Jr Oxidative Stress Markers Are Associated with Persistent Atrial Fibrillation Clin. Chem., September 1, 2007; 53(9): 1652 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Adam, G. Frost, F. Custodis, M. A. Sussman, H.-J. Schafers, M. Bohm, and U. Laufs Role of Rac1 GTPase Activation in Atrial Fibrillation J. Am. Coll. Cardiol., July 24, 2007; 50(4): 359 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.S. Kostapanos, E.N. Liberopoulos, J.A. Goudevenos, D.P. Mikhailidis, and M.S. Elisaf Do statins have an antiarrhythmic activity? Cardiovasc Res, July 1, 2007; 75(1): 10 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nattel, A. Maguy, S. Le Bouter, and Y.-H. Yeh Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation Physiol Rev, April 1, 2007; 87(2): 425 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Van Gelder Rhythm control for atrial fibrillation: Non-channel antiarrhythmic drugs are en vogue Cardiovasc Res, April 1, 2007; 74(1): 8 - 10. [Full Text] [PDF]
|
|
|
|
|
|
A. Shiroshita-Takeshita, B. J.J.M. Brundel, B. Burstein, T.-K. Leung, H. Mitamura, S. Ogawa, and S. Nattel Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure Cardiovasc Res, April 1, 2007; 74(1): 75 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. J. M. Brundel, A. Shiroshita-Takeshita, X. Qi, Y.-H. Yeh, D. Chartier, I. C. van Gelder, R. H. Henning, H. H. Kampinga, and S. Nattel Induction of Heat Shock Response Protects the Heart Against Atrial Fibrillation Circ. Res., December 8, 2006; 99(12): 1394 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yin, D. Dalal, and J. Dong Anti-inflammatory effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: potential benefits for the prevention of atrial fibrillation: reply Eur. Heart J., October 1, 2006; 27(19): 2371 - 2371. [Full Text] [PDF]
|
|
|
|
|
|
J. J. Goldberger, H. Subacius, A. Schaechter, A. Howard, R. Berger, A. Shalaby, J. Levine, A. H. Kadish, and for the DEFINITE Investigators Effects of Statin Therapy on Arrhythmic Events and Survival in Patients With Nonischemic Dilated Cardiomyopathy J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1228 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Writing Committee Members, V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society Europace, September 1, 2006; 8(9): 651 - 745. [Full Text] [PDF]
|
|
|
|
|
|
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society J. Am. Coll. Cardiol., August 15, 2006; 48(4): e149 - e246. [Full Text] [PDF]
|
|
|
|
|
|
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society Circulation, August 15, 2006; 114(7): e257 - e354. [Full Text] [PDF]
|
|
|
|
|
|
A. Shiroshita-Takeshita, B. J.J.M. Brundel, J. Lavoie, and S. Nattel Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs Cardiovasc Res, March 1, 2006; 69(4): 865 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Boos, R. A. Anderson, and G. Y.H. Lip Is atrial fibrillation an inflammatory disorder? Eur. Heart J., January 2, 2006; 27(2): 136 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D.M. Engelmann and J. H. Svendsen Inflammation in the genesis and perpetuation of atrial fibrillation Eur. Heart J., October 2, 2005; 26(20): 2083 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Wolin and S. A. Gupte Novel Roles for Nox Oxidases in Cardiac Arrhythmia and Oxidized Glutathione Export in Endothelial Function Circ. Res., September 30, 2005; 97(7): 612 - 614. [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Kim, T. J. Guzik, Y. H. Zhang, M. H. Zhang, H. Kattach, C. Ratnatunga, R. Pillai, K. M. Channon, and B. Casadei A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation Circ. Res., September 30, 2005; 97(7): 629 - 636. [Abstract] [Full Text] [PDF]
|
|