on September 13, 2004
Published online before print September 13, 2004, doi: 10.1161/01.CIR.0000142863.71285.74
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on October 7, 2003
From the Institute for Exercise and Environmental Medicine, Presbyterian Hospital, and University of Texas Southwestern Medical Center, Dallas, Tex (A.A.-Z., A.P., Q.F., P.T., R.Z., D.P., B.D.L.); University Medical Center, Nijmegen, Netherlands (E.D.); and Cleveland Clinic Foundation, Cleveland, Ohio (J.D.T.). * To whom correspondence should be addressed. E-mail: benjaminlevine{at}texashealth.org.
Background--Left ventricular compliance appears to decrease with aging, which may contribute to the high incidence of heart failure in the elderly. However, whether this change is an inevitable consequence of senescence or rather secondary to reduced physical activity is unknown. Methods and Results--Twelve healthy sedentary seniors (69.8±3 years old; 6 women, 6 men) and 12 Masters athletes (67.8±3 years old; 6 women, 6 men) underwent pulmonary artery catheterization to define Starling and left ventricular pressure-volume curves. Data were compared with those obtained in 14 young but sedentary control subjects (28.9±5 years old; 7 women, 7 men). Pulmonary capillary wedge pressures and left ventricular end-diastolic volumes by use of echocardiography were measured at baseline, during decreased cardiac filling by use of lower-body negative pressure (-15 and -30 mm Hg), and after saline infusion (15 and 30 mL/kg). Stroke volume for any given filling pressure was greater in Masters athletes compared with the age-matched sedentary subjects, whereas contractility, as assessed by preload recruitable stroke work, was similar. There was substantially decreased left ventricular compliance in healthy but sedentary seniors compared with the young control subjects, which resulted in higher cardiac pressures for a given filling volume and higher myocardial wall stress for a given strain. The pressure-volume curve for the Masters athletes was indistinguishable from that of the young, sedentary control subjects. Conclusions--A sedentary lifestyle during healthy aging is associated with decreased left ventricular compliance, leading to diminished diastolic performance. Prolonged, sustained endurance training preserves ventricular compliance with aging and may help to prevent heart failure in the elderly.
Revised on May 20, 2004
Accepted on June 2, 2004
Effect of Aging and Physical Activity on Left Ventricular Compliance
Armin Arbab-Zadeh MD,
Key words: aging • diastole • exercise • hemodynamics • myocardium
This article has been cited by other articles:
 |
|
 |
|
  P. S Bhella, S. Shibata, J. L Hastings, A. Prasad, A. Arbab-Zadeh, N. Minniefield, M. D Palmer, J. McLoughlin, D. Creson, and B. D Levine Abstract 1535: Lifelong Exercise Training Demonstrates a Dose Dependent Effect on Left Ventricular Compliance and Distensibility Circulation, November 3, 2009; 120(18_MeetingAbstracts): S512 - S512.
|
|
|
|
 |
|
 K. L. Hess, T. E. Wilson, C. L. Sauder, Z. Gao, C. A. Ray, and K. D. Monahan Aging affects the cardiovascular responses to cold stress in humans J Appl Physiol, October 1, 2009; 107(4): 1076 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Wilson, R. M. Brothers, C. Tollund, E. A. Dawson, P. Nissen, C. C. Yoshiga, C. Jons, N. H. Secher, and C. G. Crandall Effect of thermal stress on Frank\#8211;Starling relations in humans J. Physiol., July 1, 2009; 587(13): 3383 - 3392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Esch, J. M. Scott, D. E.R. Warburton, R. Thompson, D. Taylor, J. C. Baron, I. Paterson, and M. J. Haykowsky Left ventricular torsion and untwisting during exercise in heart transplant recipients J. Physiol., May 15, 2009; 587(10): 2375 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Fu, W. Vongpatanasin, and B. D. Levine Neural and Nonneural Mechanisms for Sex Differences in Elderly Hypertension: Can Exercise Training Help? Hypertension, November 1, 2008; 52(5): 787 - 794. [Full Text] [PDF]
|
|
|
|
 |
|
 G J King, R T Murphy, I Almuntaser, K Bennett, E Ho, and A S Brown Alterations in myocardial stiffness in elite athletes assessed by a new Doppler index Heart, October 1, 2008; 94(10): 1323 - 1325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Dorfman, B. D. Rosen, M. A. Perhonen, T. Tillery, R. McColl, R. M. Peshock, and B. D. Levine Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting J Appl Physiol, April 1, 2008; 104(4): 1037 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shibata, J. L. Hastings, A. Prasad, Q. Fu, K. Okazaki, M. D. Palmer, R. Zhang, and B. D. Levine 'Dynamic' Starling mechanism: effects of ageing and physical fitness on ventricular-arterial coupling J. Physiol., April 1, 2008; 586(7): 1951 - 1962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Li, T. Coates, and J. C. Wood Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major Haematologica, February 1, 2008; 93(2): 311 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tanaka and D. R. Seals Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms J. Physiol., January 1, 2008; 586(1): 55 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H.J. Thijssen, M. T.E. Hopman, and B. D. Levine Endothelin and Aged Blood Vessels: One More Reason to Get Off the Couch? Hypertension, August 1, 2007; 50(2): 292 - 293. [Full Text] [PDF]
|
|
|
|
|
|
T. A. Dorfman, B. D. Levine, T. Tillery, R. M. Peshock, J. L. Hastings, S. M. Schneider, B. R. Macias, G. Biolo, and A. R. Hargens Cardiac atrophy in women following bed rest J Appl Physiol, July 1, 2007; 103(1): 8 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. T. A. Esch, J. M. Scott, M. J. Haykowsky, D. C. McKenzie, and D. E. R. Warburton Diastolic ventricular interactions in endurance-trained athletes during orthostatic stress Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H409 - H415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. T. A. Esch, J. M. Scott, and D. E. R. Warburton Construction of a lower body negative pressure chamber Advan Physiol Educ, March 1, 2007; 31(1): 76 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. W. De Keulenaer and D. L. Brutsaert Systolic and diastolic heart failure: Different phenotypes of the same disease? Eur J Heart Fail, February 1, 2007; 9(2): 136 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Harper and H. M. Haqqani Spontaneous Late Closure of Patent Foramen Ovale J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1913 - 1913. [Full Text] [PDF]
|
|
|
|
|
|
S. Shibata, R. Zhang, J. Hastings, Q. Fu, K. Okazaki, K.-i. Iwasaki, and B. D. Levine Cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2142 - H2151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. B. Popovic, K. E. Richards, N. L. Greenberg, A. Rovner, J. Drinko, Y. Cheng, M. S. Penn, K. Fukamachi, N. Mal, B. D. Levine, et al. Scaling of diastolic intraventricular pressure gradients is related to filling time duration Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H762 - H769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Stickland, R. C. Welsh, S. R. Petersen, J. V. Tyberg, W. D. Anderson, R. L. Jones, D. A. Taylor, M. Bouffard, and M. J. Haykowsky Does fitness level modulate the cardiovascular hemodynamic response to exercise? J Appl Physiol, June 1, 2006; 100(6): 1895 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. B. Popovic, A. Prasad, M. J. Garcia, A. Arbab-Zadeh, A. Borowski, E. Dijk, N. L. Greenberg, B. D. Levine, and J. D. Thomas Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1454 - H1459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Januzzi, R. van Kimmenade, J. Lainchbury, A. Bayes-Genis, J. Ordonez-Llanos, M. Santalo-Bel, Y. M. Pinto, and M. Richards NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: The International Collaborative of NT-proBNP Study Eur. Heart J., February 1, 2006; 27(3): 330 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P McCrory The lean and slippered pantaloon... Br. J. Sports Med., December 1, 2005; 39(12): 879 - 879. [Full Text] [PDF]
|
|
|
|
|
|
K. Okazaki, K.-i. Iwasaki, A. Prasad, M. D. Palmer, E. R. Martini, Q. Fu, A. Arbab-Zadeh, R. Zhang, and B. D. Levine Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors J Appl Physiol, September 1, 2005; 99(3): 1041 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Prasad, K. Okazaki, A. A. Zadeh, E. Dijk, Q. Fu, J. D. Thomas, and B. D. Levine Abnormalities of Doppler Measures of Diastolic Function in the Healthy Elderly Are Not Related to Alterations of Left Atrial Pressure Circulation, March 29, 2005; 111(12): 1499 - 1503. [Abstract] [Full Text] [PDF]
|
|