on July 19, 2004
Circulation. 2004
Published online before print July 19, 2004, doi: 10.1161/01.CIR.0000138154.00779.A5
Published online before print July 19, 2004, doi: 10.1161/01.CIR.0000138154.00779.A5
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on May 4, 2004
From the Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, and Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, Mass (D.M., E.B.R.); Cardiovascular Health Research Unit, Departments of Medicine (B.M.P, R.N.L., D.S.S.) and Epidemiology (B.M.P., D.S.S.), University of Washington, Seattle, Wash; and Departments of Public Health Sciences (G.L.B.), Medicine (M.F.L.), and Neurology (D.L.), Wake Forest University School of Medicine, Winston-Salem, NC. * To whom correspondence should be addressed. E-mail: darymd{at}hotmail.com.
Background--Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is particularly common in the elderly. Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated. Methods and Results--In a prospective, population-based cohort of 4815 adults Conclusions--Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.
Revised on May 28, 2004
Accepted on June 3, 2004
Fish Intake and Risk of Incident Atrial Fibrillation
Dariush Mozaffarian MD, MPH*,
age 65 years, usual dietary intake was assessed at baseline in 1989 and 1990. Consumption of tuna and other broiled or baked fish correlated with plasma phospholipid long-chain n-3 fatty acids, whereas consumption of fried fish or fish sandwiches (fish burgers) did not. AF incidence was prospectively ascertained on the basis of hospital discharge records and annual electrocardiograms. During 12 years’ follow-up, 980 cases of incident AF were diagnosed. In multivariate analyses, consumption of tuna or other broiled or baked fish was inversely associated with incidence of AF, with 28% lower risk with intake 1 to 4 times per week (HR=0.72, 95% CI=0.58 to 0.91, P=0.005), and 31% lower risk with intake 5 times per week (HR=0.69, 95% CI=0.52 to 0.91, P=0.008), compared with <1 time per month (P trend=0.004). Results were not materially different after adjustment for preceding myocardial infarction or congestive heart failure. In similar analyses, fried fish/fish sandwich consumption was not associated with lower risk of AF.
Key words: fibrillation, atrial • diet • fish • aging • nutrition
This article has been cited by other articles:
 |
|
 |
|
  D. Mozaffarian, C. D. Furberg, B. M. Psaty, and D. Siscovick Physical Activity and Incidence of Atrial Fibrillation in Older Adults: The Cardiovascular Health Study Circulation, August 19, 2008; 118(8): 800 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. J. Jung, C. Torrejon, A. P Tighe, and R. J Deckelbaum n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects Am. J. Clinical Nutrition, June 1, 2008; 87(6): 2003S - 2009S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian, P. K. Stein, R. J. Prineas, and D. S. Siscovick Dietary Fish and {omega}-3 Fatty Acid Consumption and Heart Rate Variability in US Adults Circulation, March 4, 2008; 117(9): 1130 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Echahidi, P. Pibarot, G. O'Hara, and P. Mathieu Mechanisms, Prevention, and Treatment of Atrial Fibrillation After Cardiac Surgery J. Am. Coll. Cardiol., February 26, 2008; 51(8): 793 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Laurent, G. Moe, X. Hu, B. Holub, H. Leong-Poi, J. Trogadis, K. Connelly, D. Courtman, B. H. Strauss, and P. Dorian Long chain n-3 polyunsaturated fatty acids reduce atrial vulnerability in a novel canine pacing model Cardiovasc Res, January 1, 2008; 77(1): 89 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sakabe, A. Shiroshita-Takeshita, A. Maguy, C. Dumesnil, A. Nigam, T.-K. Leung, and S. Nattel Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation Associated With Heart Failure but Not Atrial Tachycardia Remodeling Circulation, November 6, 2007; 116(19): 2101 - 2109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pepe and P. L. McLennan (n-3) Long Chain PUFA Dose-Dependently Increase Oxygen Utilization Efficiency and Inhibit Arrhythmias after Saturated Fat Feeding in Rats J. Nutr., November 1, 2007; 137(11): 2377 - 2383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian Fish Oil and Prevention of Atrial Fibrillation J. Am. Coll. Cardiol., October 9, 2007; 50(15): 1513 - 1514. [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Sarrazin, G. Comeau, P. Daleau, J. Kingma, I. Plante, D. Fournier, and F. Molin Reduced Incidence of Vagally Induced Atrial Fibrillation and Expression Levels of Connexins by n-3 Polyunsaturated Fatty Acids in Dogs J. Am. Coll. Cardiol., October 9, 2007; 50(15): 1505 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. PEPE Dietary Polyunsaturated Fatty Acids and Age-Related Membrane Changes in the Heart Ann. N.Y. Acad. Sci., October 1, 2007; 1114(1): 381 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. London, C. Albert, M. E. Anderson, W. R. Giles, D. R. Van Wagoner, E. Balk, G. E. Billman, M. Chung, W. Lands, A. Leaf, et al. Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research: A Report from the National Heart, Lung, and Blood Institute and Office of Dietary Supplements Omega-3 Fatty Acids and Their Role in Cardiac Arrhythmogenesis Workshop Circulation, September 4, 2007; 116(10): e320 - e335. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kreimer A Provider Primer on Omega-3 DOC News, September 1, 2007; 4(9): 6 - 6. [Full Text]
|
|
|
|
 |
|
 W. L Baker and C M. White Post-Cardiothoracic Surgery Atrial Fibrillation: A Review of Preventive Strategies Ann. Pharmacother., April 1, 2007; 41(4): 587 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Oda n 3 Fatty acids and the endocannabinoid system Am. J. Clinical Nutrition, March 1, 2007; 85(3): 919 - 919. [Full Text] [PDF]
|
|
|
|
|
|
C. von Schacky and W. S. Harris Cardiovascular benefits of omega-3 fatty acids Cardiovasc Res, January 15, 2007; 73(2): 310 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mozaffarian and E. B. Rimm Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA, October 18, 2006; 296(15): 1885 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Writing Committee Members, V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society Europace, September 1, 2006; 8(9): 651 - 745. [Full Text] [PDF]
|
|
|
|
|
|
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society J. Am. Coll. Cardiol., August 15, 2006; 48(4): 854 - 906. [Full Text] [PDF]
|
|
|
|
|
|
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society J. Am. Coll. Cardiol., August 15, 2006; 48(4): e149 - e246. [Full Text] [PDF]
|
|
|
|
|
|
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society Circulation, August 15, 2006; 114(7): e257 - e354. [Full Text] [PDF]
|
|
|
|
|
|
V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, J. E. Lowe, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society Circulation, August 15, 2006; 114(7): 700 - 752. [Full Text] [PDF]
|
|
|
|
 |
|
 Authors/Task Force Members, V. Fuster, L. E. Ryden, D. S. Cannom, H. J. Crijns, A. B. Curtis, K. A. Ellenbogen, J. L. Halperin, J.-Y. Le Heuzey, G. N. Kay, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society Eur. Heart J., August 2, 2006; 27(16): 1979 - 2030. [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian, R. J. Prineas, P. K. Stein, and D. S. Siscovick Dietary Fish and n-3 Fatty Acid Intake and Cardiac Electrocardiographic Parameters in Humans J. Am. Coll. Cardiol., August 1, 2006; 48(3): 478 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L Breslow n-3 Fatty acids and cardiovascular disease Am. J. Clinical Nutrition, June 1, 2006; 83(6): S1477 - 1482S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hoang and T. Canada {Omega}-3 Fatty Acids for the Prevention of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Randomized, Controlled Trial Nutr Clin Pract, April 1, 2006; 21(2): 189 - 190. [Abstract] [Full Text]
|
|
|
|
|
|
C. J. Boos, R. A. Anderson, and G. Y.H. Lip Is atrial fibrillation an inflammatory disorder? Eur. Heart J., January 2, 2006; 27(2): 136 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Strauss, P. Dorian, and S. Verma Fish Oil Supplementation and Arrhythmias JAMA, November 2, 2005; 294(17): 2165 - 2165. [Full Text] [PDF]
|
|
|
|
|
|
W. C. Stanley, F. A. Recchia, and I. C. Okere Metabolic therapies for heart disease: Fish for prevention and treatment of cardiac failure? Cardiovasc Res, November 1, 2005; 68(2): 175 - 177. [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian, A. Geelen, I. A. Brouwer, J. M. Geleijnse, P. L. Zock, and M. B. Katan Effect of Fish Oil on Heart Rate in Humans: A Meta-Analysis of Randomized Controlled Trials Circulation, September 27, 2005; 112(13): 1945 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mozaffarian, C. L. Bryson, R. N. Lemaitre, G. L. Burke, and D. S. Siscovick Fish Intake and Risk of Incident Heart Failure J. Am. Coll. Cardiol., June 21, 2005; 45(12): 2015 - 2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Calo, L. Bianconi, F. Colivicchi, F. Lamberti, M. L. Loricchio, E. de Ruvo, A. Meo, C. Pandozi, M. Staibano, and M. Santini N-3 Fatty Acids for the Prevention of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Randomized, Controlled Trial J. Am. Coll. Cardiol., May 17, 2005; 45(10): 1723 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Bourassa Angiotensin II inhibition and prevention of atrial fibrillation and stroke J. Am. Coll. Cardiol., March 1, 2005; 45(5): 720 - 721. [Full Text] [PDF]
|
|
|
|
|
|
J. H. Christensen, E. B. Schmidt, E. Toft, D. Mozaffarian, E. B. Rimm, B. M. Psaty, D. S. Siscovick, R. N. Lemaitre, G. L. Burke, M. F. Lyles, et al. Letter Regarding Article by Mozaffarian et al, "Fish Intake and Risk of Incident Atrial Fibrillation" * Response Circulation, February 1, 2005; 111(4): e37 - e37. [Full Text] [PDF]
|
|
|
|
 |
|
 Eat Fish to Prevent Afib? Journal Watch Cardiology, October 1, 2004; 2004(1001): 3 - 3. [Full Text]
|
|