Published Online
on July 6, 2004

A more recent version of this article appeared on July 27, 2004

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Submitted on November 10, 2003
Revised on March 18, 2004
Accepted on March 24, 2004

Serum Total and Lipoprotein Cholesterol Levels and Awareness, Treatment, and Control of Hypercholesterolemia in China

Jiang He MD, PhD, Dongfeng Gu MD, MS, Kristi Reynolds MPH, Xigui Wu MD, Paul Muntner PhD, Jiangong Zhao MD^*, Jing Chen MD, MS, Donghai Liu BS, Jingping Mo MD, PhD, Paul K. Whelton MD, MSc, for the InterASIA Collaborative Group

From the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine (J.H., K.R., P.M., P.K.W.) and Department of Medicine, Tulane University School of Medicine (J.H., P.M., J.C., P.W.), New Orleans, La; the Cardiovascular Institute and Fuwai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G., X.W., J.Z., D.L.); and Pfizer Inc, New York, NY (J.M.).

^* To whom correspondence should be addressed. E-mail: jhe{at}tulane.edu.

Background--Cardiovascular disease has become the leading cause of death in China. We examined the levels of serum total and lipoprotein cholesterol and status of awareness, treatment, and control of hypercholesterolemia in China.

Methods and Results--A cross-sectional survey in a nationally representative sample of 15 540 Chinese adults 35 to 74 years of age was conducted during 2000 to 2001. Serum cholesterol was measured by use of standard methods, and information on treatment of hyperlipidemia was obtained by use of a standard questionnaire. Age-standardized mean levels of total, HDL, and LDL cholesterol and triglycerides were 186.1, 51.7, 109.5, and 128.1 mg/dL, respectively. Of the Chinese population 35 to 74 years of age, 23.8% (112 500 000 persons) had borderline high total cholesterol (200 to 239 mg/dL), and 9.0% (42 540 000 persons) had high total cholesterol (240 mg/dL). The population estimates for borderline high (130 to 159 mg/dL), high (160 to 189 mg/dL), and very high (190 mg/dL) LDL cholesterol were 17.0% (80 122 000 persons), 5.1% (24 329 000 persons), and 2.7% (12 822 000 persons), respectively. In addition, 19.2%, or 90 803 000 persons, had a low HDL cholesterol (<40 mg/dL). Among those who had a total cholesterol 200 mg/dL or who were on cholesterol-lowering medications, the proportion of men and women who were aware, treated, and controlled was only 8.8% and 7.5%, 3.5% and 3.4%, and 1.9% and 1.5%, respectively.

Conclusions--The prevalence of hypercholesterolemia was relatively high and the percentage of adults with controlled blood cholesterol was low in China. Prevention and treatment of hypercholesterolemia should be an important component of a national strategy to reduce the substantial and increasing burden of cardiovascular disease in China.

Key words: hypercholesterolemia • prevalence • awareness • cross-sectional studies • China

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