Published Online
on July 12, 2004

A more recent version of this article appeared on July 27, 2004

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Submitted on February 6, 2004
Revised on May 6, 2004
Accepted on May 10, 2004

Treatment of Left Anterior Descending Coronary Artery Disease With Sirolimus-Eluting Stents

Neil Sawhney MD, Jeffrey W. Moses MD, Martin B. Leon MD, Richard E. Kuntz MD, Jeffrey J. Popma MD, William Bachinsky MD, Theodore Bass MD, Samuel DeMaio MD, Edward Fry MD, David R. Holmes Jr MD, and Paul S. Teirstein MD^*

From the Division of Cardiology, Scripps Clinic, San Diego, Calif (N.S., P.S.T.); the Cardiovascular Research Foundation, New York, NY (J.W.M., M.B.L.); Harvard Clinical Research Institute, Boston, Mass (R.E.K.); Brigham and Women’s, Boston, Mass (J.J.P.); Harrisburg Hospital, Harrisburg, Pa (W.B.); the University of Florida, Jacksonville (T.B.); Seton Medical Center, Austin, Tex (S.D.); St Vincent’s Hospital, Indianapolis, Ind (E.F.); and the Mayo Clinic, Rochester, Minn (D.R.H.).

^* To whom correspondence should be addressed. E-mail: pteirstein{at}scrippsclinic.com.

Background--Revascularization strategies often hinge on the presence and degree of left anterior descending coronary artery (LAD) stenosis. A decision for bypass surgery is often based on the durability of surgical LAD revascularization compared with percutaneous approaches. By decreasing restenosis, drug-eluting stents may have reduced the "reintervention gap" between surgery and percutaneous intervention, making the percutaneous route preferable.

Methods and Results--Of the 1101 patients in the SIRIUS trial, 459 with an LAD stenosis were randomized to percutaneous intervention with either sirolimus-eluting or bare-metal stents. Baseline demographic, clinical, and angiographic data were obtained. Patients had 1-year clinical and 8-month angiographic follow-up. Baseline characteristics were similar in both groups. The majority of lesions were tubular type B lesions (69.7%) with a mean diameter of 2.73 mm and a mean length of 14.0 mm. The binary in-stent restenosis rate was 2% for the sirolimus stent group and 41.6% for the bare-metal arm (relative risk, 0.05; 95% CI, 0.02 to 0.1; P<0.001). One-year major adverse events (defined as cardiac death, Q-wave and non-Q-wave myocardial infarction, or target vessel revascularization) was decreased 59% in the sirolimus-stent group (9.8% versus 24.9%; relative risk, 0.39; 95% CI, 0.26 to 0.61; P<0.001). Subgroup analysis of 135 patients with proximal LAD lesions showed similar benefits. In-stent restenosis was 0 in the proximal LAD sirolimus-eluting group (n=67), compared with 38% in the bare-metal arm (n=68), and major adverse events demonstrated a similar trend, with a 50% decrease compared with control patients (10.4% versus 20.6%, P=NS).

Conclusions--Sirolimus-eluting stents significantly decrease revascularization rates in LAD lesions. At 1 year, sirolimus-eluting stent revascularization rates are comparable to historic single vessel bypass surgery revascularization rates.

Key words: angioplasty • stents • cardiovascular disease

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